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Open AccessReview

A Review on Microdevices for Isolating Circulating Tumor Cells

by Kin Fong Lei 1,2
1
Graduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan 333, Taiwan
2
Department of Radiation Oncology, Chang Gung Memorial Hospital, Linkou 333, Taiwan
Micromachines 2020, 11(5), 531; https://doi.org/10.3390/mi11050531
Received: 17 April 2020 / Revised: 12 May 2020 / Accepted: 20 May 2020 / Published: 22 May 2020
Cancer metastasis is the primary cause of high mortality of cancer patients. Enumeration of circulating tumor cells (CTCs) in the bloodstream is a very important indicator to estimate the therapeutic outcome in various metastatic cancers. The aim of this article is to review recent developments on the CTC isolation technologies in microdevices. Based on the categories of biochemical and biophysical isolation approaches, a literature review and in-depth discussion will be included to provide an overview of this challenging topic. The current excellent developments suggest promising CTC isolation methods in order to establish a precise indicator of the therapeutic outcome of cancer patients.
Keywords: cancer metastasis; circulating tumor cells; CTC isolation; microdevices cancer metastasis; circulating tumor cells; CTC isolation; microdevices
MDPI and ACS Style

Lei, K.F. A Review on Microdevices for Isolating Circulating Tumor Cells. Micromachines 2020, 11, 531.

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