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Nutrients, Volume 13, Issue 11

November 2021 - 518 articles

Cover Story: Our study delineated cell targets and actions of per- and polyfluoroalkyl substances (PFAS) that drive prostate carcinogenesis and promote tumor aggressiveness. Our studies using human benign and cancerous prostate cells demonstrate that PFAS exposures increase proliferation of benign and prostate cancer (PCa) cells and synergize with a high-fat diet (HFD) to enhance PCa tumor growth in mice. Further, our data indicate that PFAS enhances glucose metabolism and pyruvate production in PCa cells, modifies epigenetic marks, and alters the transcriptome related to proliferation and metabolism. Our paper shows that PFAS exposures together with HFD drive metabolic changes that reprogram prostate cells through epigenetic modifications that, independently or combined, initiate PCa and promote tumor progression.View this paper
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Articles (518)

  • Review
  • Open Access
279 Citations
31,703 Views
20 Pages

Obesity and Cardiometabolic Risk Factors: From Childhood to Adulthood

  • Dorota Drozdz,
  • Julio Alvarez-Pitti,
  • Małgorzata Wójcik,
  • Claudio Borghi,
  • Rosita Gabbianelli,
  • Artur Mazur,
  • Vesna Herceg-Čavrak,
  • Beatriz Gonzalez Lopez-Valcarcel,
  • Michał Brzeziński and
  • Empar Lurbe
  • + 1 author

22 November 2021

Obesity has become a major epidemic in the 21st century. It increases the risk of dyslipidemia, hypertension, and type 2 diabetes, which are known cardiometabolic risk factors and components of the metabolic syndrome. Although overt cardiovascular (C...

  • Article
  • Open Access
9 Citations
4,503 Views
18 Pages

Blackcurrant Improves Diabetic Cardiovascular Dysfunction by Reducing Inflammatory Cytokines in Type 2 Diabetes Mellitus Mice

  • Hye-Yoom Kim,
  • Jung-Joo Yoon,
  • Hyeon-Kyoung Lee,
  • Ai-Lin Tai,
  • Yun-Jung Lee,
  • Dae-Sung Kim,
  • Dae-Gill Kang and
  • Ho-Sub Lee

22 November 2021

Diabetic cardiovascular dysfunction is a representative complication of diabetes. Inflammation associated with the onset and exacerbation of type 2 diabetes mellitus (T2DM) is an essential factor in the pathogenesis of diabetic cardiovascular complic...

  • Review
  • Open Access
65 Citations
14,463 Views
15 Pages

The Effects of Shift Work on Cardio-Metabolic Diseases and Eating Patterns

  • Alexandra Hemmer,
  • Julie Mareschal,
  • Charna Dibner,
  • Jacques A. Pralong,
  • Victor Dorribo,
  • Stephen Perrig,
  • Laurence Genton,
  • Claude Pichard and
  • Tinh-Hai Collet

22 November 2021

Energy metabolism is tightly linked with circadian rhythms, exposure to ambient light, sleep/wake, fasting/eating, and rest/activity cycles. External factors, such as shift work, lead to a disruption of these rhythms, often called circadian misalignm...

  • Article
  • Open Access
16 Citations
5,319 Views
13 Pages

22 November 2021

This web-based cross-sectional survey aimed to elucidate the differences between the two core symptoms of night eating syndrome (NES): evening hyperphagia and nocturnal ingestion in the general Japanese population aged 16–79 years. Participants...

  • Article
  • Open Access
8 Citations
4,384 Views
10 Pages

The Potential for Healthy Checkout Policies to Advance Nutrition Equity

  • Jennifer Falbe,
  • Justin S. White,
  • Desiree M. Sigala,
  • Anna H. Grummon,
  • Sarah E. Solar and
  • Lisa M. Powell

22 November 2021

Background: As the only place in a store where all customers must pass through and wait, the checkout lane may be particularly influential over consumer purchases. Because most foods and beverages sold at checkout are unhealthy (e.g., candy, sweets,...

  • Review
  • Open Access
22 Citations
5,306 Views
21 Pages

Effects on Puberty of Nutrition-Mediated Endocrine Disruptors Employed in Agriculture

  • Anastasia Konstantina Sakali,
  • Alexandra Bargiota,
  • Ioannis G. Fatouros,
  • Athanasios Jamurtas,
  • Djuro Macut,
  • George Mastorakos and
  • Maria Papagianni

22 November 2021

Pesticide residues are largely found in daily consumed food because of their extensive use in farming and their long half-life, which prolongs their presence in the environment. Many of these pesticides act as endocrine-disrupting chemicals after pre...

  • Article
  • Open Access
13 Citations
6,162 Views
15 Pages

Risk of Developing Metabolic Syndrome Is Affected by Length of Daily Siesta: Results from a Prospective Cohort Study

  • Anne Katherine Gribble,
  • Carmen Sayón-Orea,
  • Maira Bes-Rastrollo,
  • Stefanos N. Kales,
  • Ryutaro Shirahama,
  • Miguel Ángel Martínez-González and
  • Alejandro Fernandez-Montero

22 November 2021

Background: Siesta has been associated with increased incidence of cardiovascular disease but the mechanism remains unclear. New studies into the relationship between siesta and metabolic syndrome have identified siesta length as a crucial differenti...

  • Article
  • Open Access
19 Citations
4,494 Views
11 Pages

The Fatty Acid Species and Quantity Consumed by the Breastfed Infant Are Important for Growth and Development

  • Alexandra D. George,
  • Melvin C. L. Gay,
  • Mary E. Wlodek,
  • Kevin Murray and
  • Donna T. Geddes

22 November 2021

The fatty acids (FAs) of human milk (HM) are the building blocks of the HM lipidome, contributing to infant health and development; however, this has not been comprehensively characterised with respect to infant intake. Eighteen Western Australian mo...

  • Article
  • Open Access
20 Citations
3,919 Views
24 Pages

Flavonoid Phloretin Inhibits Adipogenesis and Increases OPG Expression in Adipocytes Derived from Human Bone-Marrow Mesenchymal Stromal-Cells

  • Antonio Casado-Díaz,
  • Ángel Rodríguez-Ramos,
  • Bárbara Torrecillas-Baena,
  • Gabriel Dorado,
  • José Manuel Quesada-Gómez and
  • María Ángeles Gálvez-Moreno

22 November 2021

Phloretin (a flavonoid abundant in apple), has antioxidant, anti-inflammatory, and glucose-transporter inhibitory properties. Thus, it has interesting pharmacological and nutraceutical potential. Bone-marrow mesenchymal stem cells (MSC) have high dif...

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Nutrients - ISSN 2072-6643