Table of Contents
Mar. Drugs, Volume 16, Issue 6 (June 2018)
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Cover Story (view full-size image) Malaria has caused millions of deaths, and drug resistance against current treatments is rising; [...] Read more. Malaria has caused millions of deaths, and drug resistance against current treatments is rising; thus, new drugs directed to novel targets are urgently needed. An Australian study focused on underexplored ecological niches where ascidian-associated actinomycetes were isolated. By an approach utilizing HSQC-TOCSY NMR profiles and biological activity data, the scientists identified antiplasmodial polyketide-producing strains of actinomycetes. The extract obtained from an isolated Streptomyces sp. (USC-16018) exhibited 97% inhibition of Plasmodium falciparum at 0.2 μg/mL. Large-scale fermentation and subsequent purification of this culture resulted in the isolation of two polyketides, the new herbimycin G and the known elaiophylin, which both exhibited antiplasmodial activity. These findings stress the idea that actinomycetes are still an unexhausted source of new bioactive compounds.View this paper.