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Mar. Drugs 2018, 16(6), 208;

Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails

IMB Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia
Author to whom correspondence should be addressed.
Received: 25 April 2018 / Revised: 25 May 2018 / Accepted: 6 June 2018 / Published: 13 June 2018
(This article belongs to the Special Issue Marine Invertebrate Toxins)
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Marine cone snails are a large family of gastropods that have evolved highly potent venoms for predation and defense. The cone snail venom has exceptional molecular diversity in neuropharmacologically active compounds, targeting a range of receptors, ion channels, and transporters. These conotoxins have helped to dissect the structure and function of many of these therapeutically significant targets in the central and peripheral nervous systems, as well as unravelling the complex cellular mechanisms modulated by these receptors and ion channels. This review provides an overview of α-conotoxins targeting neuronal nicotinic acetylcholine receptors. The structure and activity of both classical and non-classical α-conotoxins are discussed, along with their contributions towards understanding nicotinic acetylcholine receptor (nAChR) structure and function. View Full-Text
Keywords: conotoxins; α-conotoxins; nicotinic acetylcholine receptors conotoxins; α-conotoxins; nicotinic acetylcholine receptors

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Abraham, N.; Lewis, R.J. Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails. Mar. Drugs 2018, 16, 208.

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