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Mar. Drugs 2018, 16(6), 210; https://doi.org/10.3390/md16060210

Isolation and Structure Elucidation of Cembranoids from a Dongsha Atoll Soft Coral Sarcophyton stellatum

1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
2
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
3
Institute of Biomedical Sciences, National Chung Hsing University, Taichung 402, Taiwan
4
Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan
5
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
6
Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan
7
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 9 May 2018 / Revised: 31 May 2018 / Accepted: 5 June 2018 / Published: 14 June 2018
(This article belongs to the Special Issue Marine Natural Products Discovery: In Honor of Late Prof. Tatsuo Higa)
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Abstract

Six new polyoxygenated cembrane-based diterpenoids, stellatumolides A–C (13), stellatumonins A and B (4 and 5), and stellatumonone (6), were isolated together with ten known related compounds (716) from the ethyl acetate (EtOAc) extract of soft coral Sarcophyton stellatum. The structures of the new compounds were established by extensive spectroscopic analyses, including 1D and 2D nuclear magnetic resonance (NMR) spectroscopy and data comparison with related structures. Compounds 8 and 14 were isolated from a natural source for the first time. The isolated metabolites were shown to be not cytotoxic against a limited panel of cancer cells. Compound 9 showed anti-inflammatory activity by reducing the expression of proinflammatory cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) proteins in lipopolysaccharide (LPS)-stimulated mouse leukaemic monocyte macrophage (RAW 264.7) cells. View Full-Text
Keywords: soft coral; Sarcophyton stellatum; cembranoid; cytotoxic activity; anti-inflammatory activity soft coral; Sarcophyton stellatum; cembranoid; cytotoxic activity; anti-inflammatory activity
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Ahmed, A.F.; Chen, Y.-W.; Huang, C.-Y.; Tseng, Y.-J.; Lin, C.-C.; Dai, C.-F.; Wu, Y.-C.; Sheu, J.-H. Isolation and Structure Elucidation of Cembranoids from a Dongsha Atoll Soft Coral Sarcophyton stellatum. Mar. Drugs 2018, 16, 210.

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