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Mar. Drugs 2018, 16(6), 177; https://doi.org/10.3390/md16060177

Asperversins A and B, Two Novel Meroterpenoids with an Unusual 5/6/6/6 Ring from the Marine-Derived Fungus Aspergillus versicolor

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
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Received: 17 April 2018 / Revised: 14 May 2018 / Accepted: 14 May 2018 / Published: 23 May 2018
(This article belongs to the Special Issue Terpenoids from Marine Organisms)
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Abstract

Asperversins A (1) and B (2), two novel meroterpenoids featuring an uncommon 5/6/6/6 ring system, along with five new analogues (37) and a known compound asperdemin (8), were obtained from the marine-derived fungus Aspergillus versicolor. Their structures and absolute configurations were confirmed by extensive spectroscopic analyses, single-crystal X-ray diffraction studies, and electronic circular dichroism (ECD) calculation. All new compounds were tested for their acetylcholinesterase enzyme (AChE) inhibitory activities and cytotoxic activities, of which compound 7 displayed moderate inhibitory activity against the AChE with an IC50 value of 13.6 μM. View Full-Text
Keywords: Aspergillus versicolor; meroterpenoids; asperversins; acetylcholinesterase enzyme Aspergillus versicolor; meroterpenoids; asperversins; acetylcholinesterase enzyme
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Li, H.; Sun, W.; Deng, M.; Qi, C.; Chen, C.; Zhu, H.; Luo, Z.; Wang, J.; Xue, Y.; Zhang, Y. Asperversins A and B, Two Novel Meroterpenoids with an Unusual 5/6/6/6 Ring from the Marine-Derived Fungus Aspergillus versicolor. Mar. Drugs 2018, 16, 177.

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