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Open AccessArticle

Absolute Configuration Determination of Retroflexanone Using the Advanced Mosher Method and Application of HPLC-NMR

School of Science (Applied Chemistry and Environmental Science), RMIT University, GPO Box 2476, Melbourne, VIC 3001, Australia
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Mar. Drugs 2018, 16(6), 205; https://doi.org/10.3390/md16060205
Received: 23 May 2018 / Revised: 6 June 2018 / Accepted: 7 June 2018 / Published: 12 June 2018
The absolute configuration of retroflexanone (1) and a closely related phlorogluinol (2) was established using the advanced Mosher method and by application of HPLC-NMR. HPLC-NMR permitted a small scale Mosher method analysis to be carried out on these unstable phloroglucinols. View Full-Text
Keywords: Mosher; retroflexanone; phloroglucinol; HPLC-NMR; secondary alcohol Mosher; retroflexanone; phloroglucinol; HPLC-NMR; secondary alcohol
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MDPI and ACS Style

Singleton, C.; Brkljača, R.; Urban, S. Absolute Configuration Determination of Retroflexanone Using the Advanced Mosher Method and Application of HPLC-NMR. Mar. Drugs 2018, 16, 205.

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