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Mar. Drugs 2018, 16(6), 213;

Raistrickiones A−E from a Highly Productive Strain of Penicillium raistrickii Generated through Thermo Change

College of Pharmacy, Binzhou Medical University, Yantai 264003, China
Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
Author to whom correspondence should be addressed.
Received: 25 May 2018 / Revised: 13 June 2018 / Accepted: 15 June 2018 / Published: 18 June 2018
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Three new diastereomers of polyketides (PKs), raistrickiones A−C (13), together with two new analogues, raistrickiones D and E (4 and 5), were isolated from a highly productive strain of Penicillium raistrickii, which was subjected to an experimental thermo-change strategy to tap its potential of producing new secondary metabolites. Metabolites 1 and 2 existed in a diastereomeric mixture in the crystal packing according to the X-ray data, and were laboriously separated by semi-preparative HPLC on a chiral column. The structures of 15 were determined on the basis of the detailed analyses of the spectroscopic data (UV, IR, HRESIMS, 1D, and 2D NMR), single-crystal X-ray diffractions, and comparison of the experimental and calculated electronic circular dichroism spectra. Compounds 15 represented the first case of 3,5-dihydroxy-4-methylbenzoyl derivatives of natural products. Compounds 15 exhibited moderate radical scavenging activities against 1,1-diphenyl-2-picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl (DPPH). View Full-Text
Keywords: Penicillium raistrickii; polyketides; diastereomers; thermo-change strategy Penicillium raistrickii; polyketides; diastereomers; thermo-change strategy

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Liu, D.-S.; Rong, X.-G.; Kang, H.-H.; Ma, L.-Y.; Hamann, M.T.; Liu, W.-Z. Raistrickiones A−E from a Highly Productive Strain of Penicillium raistrickii Generated through Thermo Change. Mar. Drugs 2018, 16, 213.

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