2026 August - 103 articles
Liver sinusoidal endothelial cells are highly specialized endothelial cells that contribute to liver homeostasis through their remarkable scavenger function. Through a broad repertoire of scavenger receptors, including mannose receptor, scavenger rec...
Early hematopoietic injury is a critical determinant of hematopoietic acute radiation syndrome (H-ARS), yet biologically relevant cellular endpoints and optimal evaluation windows for therapeutic screening remain poorly defined. Here, we combined hig...
Triple negative breast cancer (TNBC) continues to have a poor prognosis relative to other forms of this disease. Previous studies have shown that the HOX family of transcription factors generally show increased expression in breast cancer and may hav...
Ischemia–reperfusion injury (IRI) remains one of the most challenging obstacles in modern medicine, influencing outcomes across cardiovascular disease, organ transplantation, stroke, peripheral ischemia, and acute surgical conditions [...]
Sustained consumption of Western-style diets (WDs), rich in fat and cholesterol, challenges metabolic homeostasis and results in organ-specific alterations, notably hepatic lipid accumulation and adipose tissue dysfunction. Medicinal mushrooms such a...
Obesity is a major health concern within the United States. Previous studies have shown that a diet high in monounsaturated fatty acids (MUFA) may help combat metabolic disease by improving cardiometabolic and inflammatory status. Pecans have high MU...
The immune system is a critical system in evolutionary biology, shaped by coevolution between hosts and pathogens. The frog Xenopus is a valuable model organism for studying this process, offering insights into amphibian development, immunity, and th...
Akebia trifoliata is an important Chinese traditional medicinal plant, and its abundant triterpenoids are the primary active medicinal components. However, the oxidosqualene cyclase (OSC) gene family responsible for constructing their triterpenoid sk...
Diarrheagenic Escherichia coli (DEC) is a leading enteric pathogen in children under five in sub-Saharan Africa, yet conventional targeted assays fail to capture mixed virulence signatures or provide quantitative context relative to E. coli carriage....
Strawberry is a globally important yet stress-sensitive crop, increasingly threatened by combined abiotic and biotic stresses. Unlike single stresses, combined stresses elicit unique, non-additive responses through complex signaling and gene regulato...
Traditional bioenergetic paradigms historically relied on classical equilibrium thermodynamics to calculate mitochondrial kinetics, often overlooking the non-equilibrium processes dictated by complex structural architecture. Recent discoveries fundam...
Functional cure of chronic hepatitis B virus (HBV) infection remains a significant challenge, making viral-entry-blocking antibodies a promising antiviral strategy. Here, we developed a structure-guided computational workflow for affinity-enhancing c...
Error in Affiliation [...]
Background/Objectives: Clear cell renal cell carcinoma (ccRCC) is frequently vascular and immune-infiltrated, yet durable responses to immune checkpoint blockade remain limited. This suggests that immune resistance may reflect tumor microenvironmenta...
The intracellular iron levels are tightly controlled by the coordinated action of specialized proteins that regulate iron uptake, storage, and export pathways in response to iron availability. For example, Ferroportin serves as the sole mammalian iro...
The RING-type E3 ubiquitin ligase plays a significant role in plant responses and adaptations to abiotic stresses such as drought. However, few studies have explored the role of E3 ubiquitin ligases in potato drought stress, especially DRIP1. In this...
Spinal cord injury (SCI) often results in varying degrees of motor and sensory dysfunction with limited potential for recovery. Research into in vivo astrocyte-to-neuron reprogramming has led to promising results that, if translated to SCI, could off...
Oral squamous cell carcinoma (OSCC) is a malignancy characterized by a complex immunosuppressive tumor microenvironment. Immunomodulatory cytokines and immune checkpoints such as PD-L1 (programmed death-ligand 1) and CTLA-4 (cytotoxic T-lymphocyte-as...
Hepatocellular carcinoma (HCC) lacks effective early diagnostic markers and is heavily driven by angiogenesis and hypoxia. Emerging evidence indicates that metabolic enzymes and noncoding RNAs coordinate these processes. Here, we reveal that phosphos...
Colorectal cancer (CRC) remains a major clinical challenge owing to its high mortality and limited therapeutic options, highlighting the urgent need for novel anticancer agents. Andrographolide (AGL), the principal bioactive compound isolated from th...
WOX transcription factors play conserved roles in plant adventitious root development, but the WOX family in pepino (Solanum muricatum) has not been systematically characterized. To investigate this family, genome-wide identification and expression a...
First-generation H2S donors fail in pulmonary arterial hypertension (PAH) not due to lack of efficacy, but because they release H2S indiscriminately. This review articulates a conceptual framework for advancing H2S donor therapy along three complemen...
Microplastic (MP) contamination in soils has raised widespread concern, yet the extent to which soil matrices regulate MP toxicity remains insufficiently characterized. In this study, the acute and subchronic toxicity of polystyrene (PS) to the earth...
V-agents are exceedingly toxic oily substances, among which phosphonothiolates VX and VR have been extensively studied. Nevertheless, V-agents encompass a large family of nerve agents with diverse structures, including the phosphonate esters of alkyl...
The Eghoria goat constitutes the major indigenous goat population in Greece and represents an important genetic resource. Despite its significance, genomic information remains scarce. This study aimed to investigate coding variation in the Eghoria go...
Bacteria are constantly exposed to stress, which intensifies as cells age, nutrients are depleted, and metabolite levels change. As metabolic activity increases, the cytoplasm transitions from a glass-like to a more fluid state, supporting the stocha...
Reverse transcription quantitative PCR (RT-qPCR) is one of the most widely used techniques for gene expression analysis in molecular biology. However, the accuracy of relative gene expression quantification largely depends on the stability of the ref...
Uncoupling protein 2 (UCP2) is expressed in various tissues throughout the body, but its expression in the spleen exceeds that of other organs. However, the precise function of UCP2 for spleen physiology is unclear. The spleen acts as a hub connectin...
Flavonoids, prominent bioactive compounds in citrus fruits, exhibit diverse health-promoting properties. However, the dynamic compositional changes in flavonoids during fruit development remain insufficiently characterized in Citrus reticulata &lsquo...
Objectives: Tenascin-C (TNC) is an extracellular matrix protein associated with tissue remodeling, tumor progression, and poor prognosis in breast cancer. Although TNC has attracted interest as a potential stromal biomarker, its baseline histopatholo...
Endoplasmic reticulum (ER) stress represents a critical pathophysiological condition that plays a central role in the development of various human diseases, including protein misfolding diseases. While the small molecule Vx-445 (Elexacaftor) exhibits...
Vanilla and vanillin are the most popular flavorings added to processed foods, medications, cosmetics, and e-cigarette liquids. Vanilla owes its unique aroma to vanillin. Both vanilla and vanillin can cause hypersensitivity reactions, probably type I...
Balanced control of intracellular deoxyribonucleoside-triphosphate (dNTP) pools is crucial for accurate DNA replication and genome stability. Deoxycytidine triphosphate pyrophosphatase 1 (DCTPP1) is a cytosolic nucleotide-sanitizing enzyme that selec...
Familial hypercholesterolemia (FH) is a common hereditary dyslipidemia characterized by high levels of low-density lipoprotein (LDL) cholesterol and a risk of premature atherosclerosis. Previous studies showed that cardiovascular risks persist in FH...
Acute Lymphoblastic Leukemia (ALL) is a highly heterogeneous hematological malignancy characterized by diverse genetic alterations. Advances in genomic and transcriptomic profiling have enabled refined ALL classification, improving clinical managemen...
Post-myocardial infarction (MI) remodeling is accompanied by metabolic stress, but the myocardial genes associated with copper handling are poorly defined. We sought to prioritize a tissue-derived candidate rather than establish a copper-dependent me...
Background: Primary hyperparathyroidism (PHPT) is usually caused by parathyroid tumors, resulting in hypercalcemia due to excessive PTH secretion. While disease severity correlates with calcium blood levels, the molecular mechanisms driving clinical...
To address the issues of low degradation efficiency in anaerobic bacteria targeting microcystin-LR (MC-LR) and the limitations of traditional genetic modification methods, this study applied ARTP mutagenesis technology for the first time to genetical...
Osteoarthritis (OA) is a chronic degenerative joint disorder characterized primarily by cartilage degradation and extensive inflammation. Its pathological progression is closely associated with the dysregulation of critical signaling pathways; conseq...
Plant functional genomics has entered an era of unprecedented resolution and scale, driven by the rapid evolution of sequencing technologies and the integration of multi-omics approaches [...]
Gastric cancer remains a leading cause of cancer-related mortality worldwide, largely due to resistance to platinum-based chemotherapy. Indoleamine 2,3-dioxygenase 1 (IDO1) has been implicated in tumor progression and immune evasion; however, its cel...
Background and objective: Natural killer (NK) cells are a subset of CD3−CD56+ lymphocytes that can recognize and destroy virus-infected and cancerous cells. Infection is the main factor contributing to morbidity and mortality in individuals wit...
Vitamin D comprises a group of fat-soluble secosteroids traditionally associated with animal physiology, calcium-phosphate homeostasis, and skeletal metabolism. However, vitamin D and related compounds have also been reported in taxonomically distinc...
Colorectal cancer (CRC) treatment with standard chemotherapeutics such as capecitabine (CAP) and irinotecan (IRT) is frequently limited by toxicity and resistance. To identify novel adjuvant strategies, we investigated the dichloromethane–metha...
The rhizosphere, the zone around the roots of plants, including the root, the soil on the root itself, and the surrounding area soil, is the hotspot for the production of reactive oxygen species (ROS). Functioning as redox signaling mediators, rhizos...
Ultraviolet B (UVB) radiation is a major environmental factor contributing to skin photoaging through excessive reactive oxygen species (ROS) generation, activation of stress-responsive signaling pathways, DNA damage, cellular senescence, and extrace...
Precision prevention and control of genetic diseases represent a major public health challenge. This paper provides a structured narrative review of advances in molecular diagnostic technologies across the preconception, preimplantation, and prenatal...
With the rapid expansion of intensive aquaculture, the frequent outbreak of diseases and the overuse of antibiotics have become increasingly critical issues. Therefore, developing green and efficient antibiotic alternatives is essential for the susta...
Pathogenic Vibrio species are a major cause of disease outbreaks in aquaculture, leading to substantial economic losses and posing risks to food safety. The increasing prevalence of antibiotic resistance among these pathogens has created an urgent ne...
Increasing evidence shows that epistasis, defined as interactive effects between genetic loci, may contribute to the missing heritability of cancer. However, systematic genome-wide epistasis identification in cancer remains challenging. Here, by leve...
of 3
