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Review

A Comprehensive Understanding of DCTPP1 as an Emerging Therapeutic Target in Liver Cancer

by
Hye In Ka
1,†,
Se Ha Jang
2,3,†,
Hyung Seok Kim
4,5,
Hyun Sun Jung
2,3 and
Jung Woo Eun
2,*
1
Department of Molecular Science & Technology, Ajou University, Suwon 16499, Republic of Korea
2
Department of Gastroenterology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 16499, Republic of Korea
3
Department of Biomedical Sciences, Ajou University Graduate School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 16499, Republic of Korea
4
Department of Biochemistry, Kosin University College of Medicine, Seo-gu, Busan 49267, Republic of Korea
5
Section of Hematology, Department of Internal Medicine and Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Curr. Issues Mol. Biol. 2026, 48(8), 770; https://doi.org/10.3390/cimb48080770
Submission received: 30 June 2026 / Revised: 23 July 2026 / Accepted: 27 July 2026 / Published: 29 July 2026
(This article belongs to the Special Issue Molecular Insights into Cancer Biomarkers: Identification and Practical Applications)
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Abstract

Balanced control of intracellular deoxyribonucleoside-triphosphate (dNTP) pools is crucial for accurate DNA replication and genome stability. Deoxycytidine triphosphate pyrophosphatase 1 (DCTPP1) is a cytosolic nucleotide-sanitizing enzyme that selectively hydrolyzes abnormal cytosine-derived triphosphates to maintain pyrimidine pool homeostasis. Dysregulated DCTPP1 expression disrupts this balance, leading to replication stress and genomic instability. Recent studies have revealed that DCTPP1 is frequently upregulated across various human cancers and contributes to tumor progression, stress tolerance, and chemoresistance. Particularly in hepatocellular carcinoma, an oncogenic DCTPP1/MYC feedback loop has been reported to rewire pyrimidine metabolism. This review summarizes the current understanding of DCTPP1 biology, highlights its emerging role in hepatocellular carcinoma, and discusses its potential therapeutic implications.
Keywords: DCTPP1; nucleotide sanitization; dNTP pool; hepatocellular carcinoma; therapeutic target DCTPP1; nucleotide sanitization; dNTP pool; hepatocellular carcinoma; therapeutic target

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MDPI and ACS Style

Ka, H.I.; Jang, S.H.; Kim, H.S.; Jung, H.S.; Eun, J.W. A Comprehensive Understanding of DCTPP1 as an Emerging Therapeutic Target in Liver Cancer. Curr. Issues Mol. Biol. 2026, 48, 770. https://doi.org/10.3390/cimb48080770

AMA Style

Ka HI, Jang SH, Kim HS, Jung HS, Eun JW. A Comprehensive Understanding of DCTPP1 as an Emerging Therapeutic Target in Liver Cancer. Current Issues in Molecular Biology. 2026; 48(8):770. https://doi.org/10.3390/cimb48080770

Chicago/Turabian Style

Ka, Hye In, Se Ha Jang, Hyung Seok Kim, Hyun Sun Jung, and Jung Woo Eun. 2026. "A Comprehensive Understanding of DCTPP1 as an Emerging Therapeutic Target in Liver Cancer" Current Issues in Molecular Biology 48, no. 8: 770. https://doi.org/10.3390/cimb48080770

APA Style

Ka, H. I., Jang, S. H., Kim, H. S., Jung, H. S., & Eun, J. W. (2026). A Comprehensive Understanding of DCTPP1 as an Emerging Therapeutic Target in Liver Cancer. Current Issues in Molecular Biology, 48(8), 770. https://doi.org/10.3390/cimb48080770

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