Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.0
4.1
Journals
CIMB
Special Issues
Stem Cell-Derived Cells and Bioengineering: Molecular Bases in Regeneration and...
cimb-logo
Submit to Special Issue Submit Abstract to Special Issue Review for CIMB Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Stem Cell-Derived Cells and Bioengineering: Molecular Bases in Regeneration and Disease Research

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 1839

Editor

Dr. Aylin Acun

E-Mail Website
Guest Editor
Department of Biomedical Engineering, Widener University, Chester, PA 19013, USA
Interests: tissue engineering; disease modeling; aging; iPSCs; interorgan communication; tissue/organ decellularization and recellularization
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Stem cell-derived cells are at the forefront of regenerative medicine and disease modeling, offering unprecedented insights into human development, tissue repair, and pathological mechanisms. This Special Issue, "Stem Cell-Derived Cells and Bioengineering: Molecular Bases in Regeneration and Disease Research", will bring together advances in stem cell technologies and bioengineering to explore their synergy in health and disease contexts. Contributions will highlight novel methods for deriving specific cell types from stem cells, molecular pathways guiding cell fate decisions, and innovative bioengineering platforms such as organoids and organ-on-chip models for mimicking physiological and pathological conditions. By integrating stem cell biology into bioengineering, this Special Issue will provide a comprehensive overview of how these tools are reshaping biomedical research, drug discovery, and the development of personalized therapies.

Dr. Aylin Acun
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stem cells
  • regenerative medicine
  • bioengineering
  • disease modeling
  • organoids
  • tissue engineering
  • decellularization
  • bioprinting

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

16 pages, 8385 KB  
Article
Radiosensitive HSPC Subsets Define Early Hematopoietic Injury and Enable H-ARS Therapeutic Screening
by Hyun Bo Sim, Dae-Han Park, Seul-Ki Mun, Yu-Jeong Choi, Ho Seong Seo, Seung-Hyun Jeong, Dong-Jo Chang and Jong-Jin Kim
Curr. Issues Mol. Biol. 2026, 48(8), 801; https://doi.org/10.3390/cimb48080801 - 7 Aug 2026
Viewed by 242
Abstract
Early hematopoietic injury is a critical determinant of hematopoietic acute radiation syndrome (H-ARS), yet biologically relevant cellular endpoints and optimal evaluation windows for therapeutic screening remain poorly defined. Here, we combined high-dimensional mass cytometry (CyTOF) and flow cytometry to characterize early hematopoietic stem [...] Read more.
Early hematopoietic injury is a critical determinant of hematopoietic acute radiation syndrome (H-ARS), yet biologically relevant cellular endpoints and optimal evaluation windows for therapeutic screening remain poorly defined. Here, we combined high-dimensional mass cytometry (CyTOF) and flow cytometry to characterize early hematopoietic stem and progenitor cell (HSPC) remodeling following 6.5 Gy total-body irradiation. Radiation exposure induced rapid bone marrow injury, with substantial cellular loss and reduced viability occurring within hours after irradiation. CyTOF analysis revealed that radiation-induced injury was characterized by selective remodeling rather than uniform depletion of the HSPC compartment. While long-term hematopoietic stem cells (LT-HSCs) were relatively preserved, short-term HSCs (ST-HSCs), multipotent progenitors (MPPs), and megakaryocyte–erythroid progenitors (MEPs) exhibited marked reductions during the early phase after irradiation. Importantly, surviving cells retained partial differentiation capacity during this period, indicating that the early post-irradiation phase represents a biologically informative window for therapeutic evaluation. These radiosensitive populations were subsequently validated using a simplified flow cytometry platform and remained detectable under short-term in vitro culture conditions. Collectively, our findings identify key radiosensitive HSPC subsets and establish an early hematopoietic injury framework that integrates optimal evaluation timing with practical cellular endpoints for H-ARS therapeutic screening and radiomitigator development. Full article
(This article belongs to the Special Issue Stem Cell-Derived Cells and Bioengineering: Molecular Bases in Regeneration and Disease Research)
►▼ Show Figures

Figure 1

19 pages, 4411 KB  
Article
ADSC-Conditioned Medium Mitigates LPS-Induced Acute Lung Injury by Inhibiting Alveolar Macrophage Pyroptosis
by Fan Yang, Jiachen Li, Ziyi Ren, Chuanyu Zhang, Mingwei Xing and Zhihui Jiao
Curr. Issues Mol. Biol. 2026, 48(3), 253; https://doi.org/10.3390/cimb48030253 - 26 Feb 2026
Viewed by 757
Abstract
Acute lung injury (ALI) is characterized by overwhelming pulmonary inflammation and high mortality, yet specific pharmacological interventions remain critically limited. Adipose-derived mesenchymal stem cell-conditioned medium (ADSC-CM) represents a novel cell-free strategy with substantial therapeutic potential. This study investigated the protective effects of ADSC-CM [...] Read more.
Acute lung injury (ALI) is characterized by overwhelming pulmonary inflammation and high mortality, yet specific pharmacological interventions remain critically limited. Adipose-derived mesenchymal stem cell-conditioned medium (ADSC-CM) represents a novel cell-free strategy with substantial therapeutic potential. This study investigated the protective effects of ADSC-CM in a rat model of lipopolysaccharide (LPS)-induced ALI. Systemic administration of ADSC-CM significantly attenuated pulmonary pathological damage, reduced systemic inflammatory cytokine levels, and inhibited pyroptosis within lung tissues. Mechanistically, in vitro studies using the NR8383 alveolar macrophage (AM) cell line revealed that ADSC-CM suppressed the TLR4/MyD88/NF-κB signaling axis and the NLRP3/Caspase-1/GSDMD-mediated pyroptotic cascade. These effects were primarily driven by the downregulation of TLR4 expression, although additional molecular targets likely contribute to this protective profile. Our findings highlight the therapeutic efficacy of ADSC-CM in modulating pyroptosis and inflammatory responses in AMs, providing a robust mechanistic rationale for developing ADSC-CM as a cell-free therapeutic platform for the management of ALI. Full article
(This article belongs to the Special Issue Stem Cell-Derived Cells and Bioengineering: Molecular Bases in Regeneration and Disease Research)
►▼ Show Figures

Figure 1

Review

Jump to: Research

18 pages, 1974 KB  
Review
Gene-Edited Stem Cells for Ischemic Vascular Disease: Current Advances and Future Perspectives
by Seongho Han and Sung-Whan Kim
Curr. Issues Mol. Biol. 2026, 48(7), 681; https://doi.org/10.3390/cimb48070681 - 2 Jul 2026
Viewed by 326
Abstract
Ischemic vascular diseases remain a leading cause of morbidity and mortality worldwide and are frequently associated with irreversible tissue damage. Although stem cell-based therapies have shown promise for vascular regeneration, their clinical translation has been limited by poor survival, insufficient engraftment, functional heterogeneity, [...] Read more.
Ischemic vascular diseases remain a leading cause of morbidity and mortality worldwide and are frequently associated with irreversible tissue damage. Although stem cell-based therapies have shown promise for vascular regeneration, their clinical translation has been limited by poor survival, insufficient engraftment, functional heterogeneity, and immune rejection. Recent advances in genome-editing technologies, including CRISPR/Cas9, base editing, and prime editing, have provided powerful tools for overcoming these limitations through precise genetic modification of stem cells. Gene editing can enhance angiogenic potential, improve resistance to ischemic stress, augment paracrine activity, promote endothelial maturation, and reduce immunogenicity. In this review, we outline the current genome-editing toolbox and its application to stem cell engineering for vascular regeneration in ischemic disease. We also examine emerging therapeutic concepts, universal donor cell platforms, and key issues in safety and ethics, with a focus on translational pathways. Taken together, advances at the interface of genome editing and stem cell biology are likely to accelerate the development of regenerative therapies that deliver more durable vascular repair in ischemic vascular disease. Full article
(This article belongs to the Special Issue Stem Cell-Derived Cells and Bioengineering: Molecular Bases in Regeneration and Disease Research)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop