Natural Phytochemicals as Modulators of Cellular Pathways and Therapeutic Targets in Disease Models
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Bioorganic Chemistry and Medicinal Chemistry".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 15
Special Issue Editor
Interests: phytochemicals; food chemistry; lipid metabolism; leukemia; neuroprotection
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue focuses on the molecular mechanisms by which plant-derived compounds modulate cellular signaling pathways relevant to health and disease. Phytochemicals such as polyphenols, alkaloids, flavonoids, terpenoids, and saponins have demonstrated potential in regulating oxidative stress, inflammation, apoptosis, autophagy, and metabolic reprogramming. Their ability to target key signaling pathways—including MAPK, PI3K/Akt, NF-κB, and Nrf2—makes them promising candidates for therapeutic development. We aim to gather original research, review articles, and translational studies investigating the effects of phytochemicals in preclinical or clinical models of cancer and neurodegenerative, cardiovascular, and metabolic disorders. Submissions addressing pharmacokinetics, bioavailability, and synergistic effects with conventional therapies are also highly encouraged. This Special Issue will provide a platform to advance our understanding of natural products as bioactive modulators and their potential roles in disease prevention and treatment.
We warmly invite you to contribute original research articles or comprehensive reviews to this Special Issue.
Prof. Dr. Jui-Hung Yen
Guest Editor
Manuscript Submission Information
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Keywords
- phytochemicals
- cellular signaling pathways
- disease models
- therapeutic targets
- synergistic effects
- natural products
- bioactive modulators
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