Molecular Mechanisms of Liver Diseases and Potential Therapeutic Targets
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 January 2027 | Viewed by 245
Editors
Interests: metabolic syndrome; autophagy; NAFLD; oxidative stress; antioxidants; behavior; anxiety; depression
Interests: epileptology; neuroinflammation; behavioral studies; molecular mechanisms of depression and anxiety; metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are pleased to invite you to contribute to this Special Issue, entitled “Molecular Mechanisms of Liver Diseases and Potential Therapeutic Targets”. Liver diseases remain a major global health challenge, with rising incidence driven by metabolic disorders, chronic inflammation, viral infections, alcohol consumption, and environmental exposures. The progression from early hepatic dysfunction to fibrosis, cirrhosis, and hepatocellular carcinoma is managed by complicated molecular networks involving metabolic dysregulation, oxidative stress, mitochondrial dysfunction, immune activation, and impaired cellular homeostasis.
Recent advances in molecular biology, omics technologies, and single-cell approaches have significantly expanded our understanding of liver pathophysiology. These insights have revealed complex interactions between hepatocytes, immune cells, stellate cells, endothelial cells, and the gut–liver axis, emphasizing the need for integrative, mechanism-based research. Elucidating these molecular pathways is essential in identifying novel biomarkers and therapeutic targets, as well as developing personalized and disease-modifying treatment strategies for liver diseases.
This Special Issue will provide a focused platform for disseminating state-of-the-art mechanistic and translational research on the molecular pathways driving liver diseases and their therapeutic modulation. The scope of this Special Issue aligns well with the journal’s focus on molecular and cellular mechanisms of disease, experimental and translational medicine, and the development of innovative therapeutic strategies.
By bringing together original research and authoritative reviews, this Special Issue will bridge basic molecular discoveries and clinical relevance, highlighting emerging targets for pharmacological, metabolic, immunological, and lifestyle-based interventions. This Special Issue is designed to be sufficiently broad to encompass diverse liver disease entities while maintaining a strong molecular focus, ensuring coherence and scientific depth.
For this Special Issue, original research articles and comprehensive review papers are welcome. Research areas may include, but are not limited to, the following themes:
- Molecular mechanisms underlying MASLD/NAFLD, NASH, alcoholic liver disease, viral hepatitis, autoimmune liver diseases, and cholestatic disorders;
- Hepatic lipid and glucose metabolism, insulin resistance, and metabolic signaling pathways;
- Oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress, and redox regulation;
- Autophagy, mitophagy, and proteostasis in liver health and disease;
- Immune responses, inflammation, inflammasome activation, and immune–metabolic crosstalk;
- Hepatic fibrosis, extracellular matrix remodeling, and stellate cell activation;
- Epigenetic regulation, non-coding RNAs, and transcriptional control in liver diseases;
- Gut–liver axis, microbiota-derived metabolites, and bile acid signaling;
- Molecular biomarkers for disease progression, prognosis, and treatment response;
- Novel therapeutic targets and strategies, including pharmacological agents, nutraceuticals, and lifestyle interventions;
- Experimental and translational models for studying liver disease mechanisms.
We warmly encourage colleagues from basic science, translational research, and clinical disciplines to submit their latest findings and contribute to advancing our molecular understanding of liver diseases and therapeutic innovation.
We look forward to receiving your contributions.
Dr. Milena Veskovic
Guest Editor
Dr. Dušan Mladenović
Co-Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pathophysiology
- molecular mechanism
- metabolism
- nutrition
- biomarkers
- liver
- insulin resistance
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