Molecular Biology and Functional Roles of Tumor Suppressor Genes in Cancer
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 16
Special Issue Editor
Interests: cancer genetics; breast cancer; genetically modified mouse models; tumor suppressors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Tumor suppressor genes (TSGs) play indispensable roles in maintaining genomic integrity, regulating cell cycle progression, and preventing malignant transformation. Their inactivation, whether by genetic mutation, epigenetic silencing, or functional deregulation, is a hallmark of cancer initiation and progression. While the role of classical TSGs such as TP53, RB1, and PTEN has been extensively studied, new insights into cell-type specificity, tumor microenvironment interactions, and emerging mechanisms continue to expand our understanding of how TSGs govern tumorigenesis.
This Special Issue of Current Issues in Molecular Biology aims to gather cutting-edge research and comprehensive reviews on the molecular biology of tumor suppressor genes and their functional impact on cancer development, progression, and therapeutic response. By highlighting both established and emerging perspectives, we hope to advance scientific discourse and foster new avenues for translational applications in cancer prevention, diagnosis, and treatment.
Suggested Themes and Article Types:
This Special Issue welcomes both original research articles and reviews. Potential topics include, but are not limited to:
- Molecular mechanisms of tumor suppressor gene regulation (transcriptional, post-transcriptional, epigenetic);
- Functional consequences of TSG mutations across different cancer types;
- Crosstalk between tumor suppressor pathways and oncogenic signaling;
- The role of TSGs in cancer stem cells and tumor heterogeneity;
- Interactions of TSGs with the tumor microenvironment and immune system;
- Clinical implications of TSG alterations for prognosis, biomarkers, and therapy;
- Novel therapeutic strategies targeting TSG-related pathways.
We are pleased to invite you to contribute your valuable research to this Special Issue. Together, we aim to provide a resource that deepens understanding of the molecular biology of tumor suppressor genes and inspires innovative therapeutic approaches.
Dr. Yun Zhang
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- tumor suppressor genes
- cancer biology
- TP53
- RB1
- PTEN
- genomic instability
- tumor microenvironment
- cancer therapy
- epigenetic regulation
- cell signaling
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