2026 October - 126 articles
Pseudostellaria heterophylla is a medicinal plant whose polysaccharides have shown metabolic and intestinal effects in animal studies. Mucus injury and bacterial encroachment are associated with metabolic disease. We evaluated colonic mucus morpholog...
The conceptual landscape of clinical oncology and cancer biology has undergone a profound transformation in recent decades, evolving from static anatomical staging and broad histopathological classification into a dynamic, molecularly stratified disc...
Turning one newly sequenced bacterial genome into a view of its biosynthetic potential still means running several cluster detectors and annotation tools and comparing their output by hand. We present BGC-XPLORER, a containerized Snakemake workflow f...
Polyendocrine metabolic ovarian syndrome (PMOS; previously termed polycystic ovary syndrome, PCOS) is a multi-faceted reproductive and endocrinological condition that affects approximately 10% of women of reproductive age. It is typically characteris...
TGA transcription factors are key regulators within the plant bZIP superfamily, coordinating stress adaptation as well as plant growth and development. Rapid-cycling Brassica rapa (RCBr) is a valuable genetic resource for investigating gene functions...
Music therapy is established in oncology as a supportive intervention to reduce anxiety, pain, distress and treatment-related symptom burden. Beyond these clinical effects, emerging experimental evidence suggests that audible sound and music may also...
Oxidative stress contributes to the pathophysiology of diverse neurodegenerative diseases and acute brain injuries. Pomegranate Seed Oil (PSO) is rich in punicic acid (PA), an omega-5 fatty acid with reported antioxidant and anti-inflammatory propert...
Diabetes Mellitus and cancer are major global health problems with rising incidence worldwide. This systematic review was conducted following PRISMA 2020 guidelines by searching PubMed, Scopus, ScienceDirect, SpringerLink, and Google Scholar for stud...
Atrial fibrillation (AF) and chronic kidney disease (CKD) are not two coincident diseases but two expressions of the cardiorenal syndrome, the disorder in which dysfunction of the heart or the kidney induces dysfunction of the other. Their coexistenc...
Esophageal adenocarcinoma (EAC) is molecularly heterogeneous, and prognostic models with clear biological context remain limited. We analyzed RNA-sequencing and clinical data from 46 EAC tumors and 13 adjacent normal tissues in The Cancer Genome Atla...
Pesticides are among the most widely used environmental contaminants worldwide, resulting in continuous human exposure primarily through dietary intake. As a major site of contact following oral exposure, the gastrointestinal tract represents a relev...
This study investigated ischemic versus nonischemic human myocardium across disease phenotypes, sex, and race, prioritizing genes involved in immune-inflammatory signaling, autophagy, JNK-associated stress responses, innate immune recognition, and so...
Visual dysfunctions were observed among Alzheimer’s disease (AD) patients, including posterior cortical degeneration, retinal abnormalities, or coexisting ocular disease. Posterior cortical atrophy (PCA) is a clinical syndrome characterized by...
Skeletal muscle adapts to diverse stresses through coordinated changes across myofibres and cellular niches, yet these responses are usually studied separately. We assembled a cross-species discovery atlas of 501,940 cells and nuclei from six public...
Obesity and diabetes are major global health burdens, with their prevalence projected to continue rising. The comorbidity of obesity and diabetes increases the risk of serious complications and mortality, highlighting the need for early prevention an...
Bipolar disorder (BD) is closely associated with multiple sclerosis (MS), but their shared molecular mechanisms and specific diagnostic biomarkers remain unclear. This study integrated microarray expression profiling and machine learning to identify...
The γ-aminobutyric acid type A (GABA-A) receptor is a key regulator of inhibitory neurotransmission in the central nervous system, and a promising target for cognitive and neurological disorders. Histamine interacts with a distinct allosteric p...
Hair loss results from disrupted hair follicle cycling, age-related hormonal imbalance, and oxidative stress, and remains a significant psychological burden for which safe, evidence-based interventions are limited. This study evaluated the effects of...
Background: Astrocytes play an important role in depression. However, their specific mechanisms, especially their subcellular mechanisms, remain unclear. Objective: We aimed to identify key genes associated with mitochondrial dynamics and astrocytes...
Red algae-derived bioactive oligosaccharides have drawn increasing attention in drug discovery, yet their therapeutic potential in crystal-induced inflammation remains underexplored. Here, we investigated the anti-inflammatory effects and underlying...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide, but effective nutritional interventions remain limited. Low glycine availability is among the most reproducible metabolomic findings...
Diabetes research increasingly connects metabolic dysfunction with the molecular processes that shape injury across organs [...]
Background: Gold nanoparticles (AuNPs) can modify cellular responses to ionizing radiation. We examined whether 1.9 nm AuNPs alter early apoptosis across a 0–8 Gy dose range in DU145 prostate and MM418-C1 melanoma cells. Methods: Cells were inc...
Background: This study investigates the relationship between clinical and hematological parameters and sub-threshold positive findings in cases with suspected hematological malignancies subjected to Janus Kinase 2 (JAK2) V617F qPCR testing. Methods:...
β-Boswellic acid (BA) has potential antitumor activity, but its effects on migration, invasion, and epithelial–mesenchymal transition (EMT)-related phenotypes in prostate cancer cells remain unclear. In this study, we integrated public tra...
Sepsis is a life-threatening, biologically heterogeneous syndrome in which immune dysregulation, endothelial injury, coagulation activation, redox imbalance, and metabolic reprogramming contribute to microvascular and organ dysfunction. This structur...
Limited docetaxel efficacy in triple-negative breast cancer (TNBC) necessitates chemosensitizers. Baicalein is a potential chemosensitizer, but its synergy with docetaxel in TNBC is unclear. Here, we investigated the combined effects and underlying m...
Algal polysaccharides have been linked to repair signaling pathways related to transforming growth factor-β1 (TGF-β1), a mediator of skin wound healing. However, to our knowledge, no study has directly confirmed the efficacy of Chlorella vu...
Background and Purpose: Follistatin-like protein 1 (Fstl1) is a secreted glycoprotein with context-dependent inflammatory activity. We investigated whether Fstl1 is a reproducible feature of traumatic spinal cord injury (SCI) and whether it regulates...
Actin remodeling accompanies myoblast proliferation, lineage commitment, elongation, fusion, and myofibril assembly, but these changes do not constitute a single linear pathway. This review separates three experimentally distinguishable scales of act...
Food-derived natural products contain a broad range of bioactive constituents, including polyphenols, flavonoids, saponins, terpenoids, alkaloids, peptides, and other secondary metabolites [...]
This study evaluated the iron status and diagnostic usefulness of iron-related parameters in patients with SARS-CoV-2 infection upon admission to the hospital and during hospitalization. The study group included 87 patients with COVID-19 and 45 healt...
Limnospira platensis (formerly Arthrospira platensis) was cultured for 14 days under simulated microgravity (SMG) generated by a three-dimensional clinostat and compared with motion-matched controls using optical density, live/dead staining and real-...
Santolina chamaecyparissus L. essential oil (EO) was investigated for its chemical composition, antifungal and insecticidal activities, together with complementary molecular docking and ADMET analyses. GC–MS revealed a monoterpene-rich profile...
Innate immune responses in Caenorhabditis elegans are regulated by multiple effectors that are activated upon bacterial exposure. In this study, we investigated the role of pgp-5, a transmembrane efflux transporter implicated in cellular stress respo...
We aimed to explore the real-world practice setting and identify common genetic signaling or patterns in cancer of unknown primary (CUP) using colon cancer as a model through RNA sequencing bioinformatics analysis. Data were retrieved and analyzed us...
Saponins are structurally diverse plant-derived glycosides that have attracted increasing interest as phytogenic feed additives for improving the efficiency and sustainability of ruminant production. This narrative review critically examines the stru...
Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) have changed the treatment of advanced bladder cancer, but only a minority of patients benefit. We asked whether expression of...
Excessive activation of PI3Kα is prevalent in breast cancer, aberrantly activating the PI3K/Akt/mTOR pathway to drive tumor progression, thus rendering PI3Kα a vital therapeutic target. Two PI3Kα inhibitors (alpelisib and inavolisib...
Chalcone synthase (CHS, EC 2.3.1.74) is a key entrance enzyme in the biosynthesis of flavonoids from the common phenylpropanoid precursor into a specific flavonoid branch. Beyond its catalytic role, CHS functions as a metabolic hub linking flavonoid...
Type 2 diabetes mellitus (T2DM), a global metabolic disease, is fundamentally characterized by a vicious cycle of chronic low-grade inflammation and metabolic dysregulation. The complement system, a key effector of innate immunity, has recently been...
In lung fibroblasts, cellular stress can disrupt tissue homeostasis through the accumulation of reactive oxygen species (ROS), loss of membrane integrity, and apoptotic cell death. In this study, the protective effects of extracellular vesicles (EV)...
Fibroblast growth factors (FGFs) are ubiquitous growth factors, with functions in all organs and cells of the embryo and the post-partum mammal, and roles in all aspects of normal and pathologic physiology. They belong to a large family of proteins c...
The Andes virus (ANDV, Orthohantavirus, andesense) is unique among hantaviruses in that it may transfer from person to person and cause severe vascular damage. The evidence on host–virus immunological interactions and their importance in diseas...
Sepsis is a life-threatening condition caused by a dysregulated host response to infection and is characterized by systemic inflammation, multiorgan dysfunction, and high mortality. Picropodophyllotoxin (PPT), a naturally occurring tyrosine kinase in...
White adipose tissue dysfunction is a central event in the development of obesity-associated metabolic disorders. Kumquat (Fortunella japonica) is consumed whole, allowing intake of peel-derived bioactive compounds. Although increasing evidence sugge...
Parkinson’s disease (PD) is characterized by progressive degeneration of the nigrostriatal dopaminergic system while increasing evidence indicates that early pathology also involves the locus coeruleus (LC) and the noradrenergic system. However...
WASHC2C encodes a WASH-complex scaffold implicated in actin remodeling, endosomal organization, and intracellular trafficking, yet its cancer-specific molecular and clinical relevance remains insufficiently defined, particularly in the context of the...
Even though there is a general agreement on the heritability of longevity in humans, the complex network of genetic and non-genetic factors affecting our lifespan is far from being fully elucidated. In this context, simple model organisms can still c...
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by substantial etiological and clinical heterogeneity. MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that play critical roles in brain...
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