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Cardiovascular Disease: From Molecular Mechanisms to Therapeutic Innovations, 2nd Edition

A Special Issue of Current Issues in Molecular Biology (ISSN 1467-3045) belonging to the section "Molecular Medicine".

Deadline for manuscript submissions: 31 January 2027 | Viewed by 559

Editors


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Guest Editor
Section of Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DIMEPReJ), University of Bari, 70124 Bari, Italy
Interests: cardiovascular pathology; head and neck diseases; immunohistochemistry; autopsies
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Pathology Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari “Aldo Moro”, 70124 Bari, Italy
Interests: cardiovascular pathology; autopsy pathology; sudden cardiac death; molecular autopsy; forensic sciences

Special Issue Information

Dear Colleagues,

Cardiovascular disease (CVD) is the leading global cause of death driven by complex genetic, molecular, and environmental factors. Advances in molecular biology have shed light on key pathways, including inflammation, oxidative stress, and lipid metabolism, offering critical insights into the mechanisms underlying conditions such as atherosclerosis and heart failure. However, challenges remain in translating these findings into effective therapies and addressing variability across populations.

Followed the first edition, this second edition still focuses on the molecular underpinnings of CVD and their implications for innovative therapeutic strategies. We welcome advanced studies, including the discovery of novel biomarkers, elucidation of disease mechanisms, development of targeted interventions, etc. By integrating multidisciplinary perspectives, this Special Issue aims to advance our understanding of CVD and bridge the gap between molecular research and clinical application, fostering progress in cardiovascular health.

Dr. Andrea Marzullo
Dr. Cecilia Salzillo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular pathophysiology
  • molecular biomarkers
  • inflammation and oxidative stress
  • therapeutic targets
  • lipid metabolism

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Published Papers (1 paper)

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Research

18 pages, 2612 KB  
Article
Lipid-Laden M1-like Macrophages of Familial Hypercholesterolemia Patients Are Characterized by Increased Interleukin-1β Secretion and Reduced TMEM176A and TMEM176B Gene Expression
by Artem Izyumchenko, Tatiana Usenko, Kseniia Dracheva, Kristina Legostaeva, Soreiia Urazgildeeva, Kseniia Tanayants, Maria Grunina, Ekaterina Larionova, Pavel Suchko, Oleg Glotov, Alexandr Kulikov, Sofya Pchelina and Valentina Miroshnikova
Curr. Issues Mol. Biol. 2026, 48(8), 769; https://doi.org/10.3390/cimb48080769 - 29 Jul 2026
Viewed by 346
Abstract
Familial hypercholesterolemia (FH) is a common hereditary dyslipidemia characterized by high levels of low-density lipoprotein (LDL) cholesterol and a risk of premature atherosclerosis. Previous studies showed that cardiovascular risks persist in FH even after hypolipidemic therapy is started and are linked to a [...] Read more.
Familial hypercholesterolemia (FH) is a common hereditary dyslipidemia characterized by high levels of low-density lipoprotein (LDL) cholesterol and a risk of premature atherosclerosis. Previous studies showed that cardiovascular risks persist in FH even after hypolipidemic therapy is started and are linked to a proinflammatory status of circulating monocytes. In the current study we aimed to identify FH-specific gene expression patterns of monocyte-derived M1-like macrophages in response to lipid accumulation. RNAseq was performed for four patient and four control paired samples of M1-like macrophages before and after incubation with oxidized LDL (oxLDL). A validation step was performed in 10 patients and 10 controls using real-time PCR and ELISA. RNAseq data analysis revealed 22 DEGs between FH patients and the control group before and 47 DEGs after incubation with oxLDL. Pathway enrichment analysis suggested dysregulation of inflammatory pathways especially IL-1 and chemokine signaling in response to lipid accumulation in FH M1-like macrophages. Validation experiments demonstrated increased interleukin-1β secretion by lipid-laden M1-like macrophages in FH patients and reduced TMEM176A and TMEM176B gene expression compared to controls. Our results suggest FH M1-like macrophages may be predisposed to an accelerated immune response via interleukin-1β due to reduced TMEM176A/B activity. Full article
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