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Molecules, Volume 25, Issue 6

March-2 2020 - 218 articles

Cover Story: Of all the human copper-containing amine oxidases, human vascular adhesion protein-1 is a specific target in drug design for the treatment of inflammatory diseases and cancer, though off-targeting of diamine oxidase should be avoided. As part of the Special Issue “Design and Application of Metal-Binding Proteins” with Guest Editor Dr. Aimin Liu, we review the structural bioinformatics and structural biology approaches that can be employed to minimize the species-specific binding properties of vascular adhesion protein-1-targeted inhibitors and improve drug safety by avoiding their binding to diamine oxidase. The 3D fold of copper-containing amine oxidase is shown on the cover. View this paper.
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Articles (218)

  • Article
  • Open Access
43 Citations
8,732 Views
17 Pages

Characterization, Quantification and Quality Assessment of Avocado (Persea americana Mill.) Oils

  • Mei Wang,
  • Ping Yu,
  • Amar G. Chittiboyina,
  • Dilu Chen,
  • Jianping Zhao,
  • Bharathi Avula,
  • Yan-Hong Wang and
  • Ikhlas A. Khan

24 March 2020

Avocado oil is prized for its high nutritional value due to the substantial amounts of triglycerides (TGs) and unsaturated fatty acids (FAs) present. While avocado oil is traditionally extracted from mature fruit flesh, alternative sources such as av...

  • Article
  • Open Access
14 Citations
4,053 Views
11 Pages

Antinociceptive Effect of Hinokinin and Kaurenoic Acid Isolated from Aristolochia odoratissima L.

  • Rosa Mariana Montiel-Ruiz,
  • Marcos Córdova-de la Cruz,
  • Manasés González-Cortázar,
  • Alejandro Zamilpa,
  • Abraham Gómez-Rivera,
  • Ricardo López-Rodríguez,
  • Carlos Ernesto Lobato-García and
  • Ever A. Blé-González

24 March 2020

Aristolochia odoratissima L. is employed for the treatment of pain and as an antidote against the poison of venomous animals in traditional medicine. However, reports have not been found, to our knowledge, about the evaluation of the antinociceptive...

  • Article
  • Open Access
26 Citations
5,398 Views
19 Pages

24 March 2020

Polyamide 6,6 (PA66)-based biocomposites with low-cost carbonaceous natural fibers (i.e., soy hulls, co-product from soybean industry) were prepared through twin-screw extrusion and injection molding. The soy hull natural fiber was pyrolyzed at two d...

  • Article
  • Open Access
20 Citations
4,199 Views
16 Pages

Interaction of Catechins with Human Erythrocytes

  • Katarzyna Naparlo,
  • Grzegorz Bartosz,
  • Ireneusz Stefaniuk,
  • Bogumil Cieniek,
  • Miroslaw Soszynski and
  • Izabela Sadowska-Bartosz

24 March 2020

The aim of this study was to characterize the interaction of chosen catechins ((+)-catechin, (−)-epigallocatechin (EGC), and (−)-epigallocatechin gallate (EGCG)) with human erythrocytes and their protective effects against oxidative damag...

  • Article
  • Open Access
20 Citations
6,607 Views
18 Pages

Carbon and Nitrogen Isotope Ratios of Food and Beverage in Brazil

  • Luiz A. Martinelli,
  • Gabriela B. Nardoto,
  • Maria A. Z. Perez,
  • Geraldo Arruda Junior,
  • Fabiana C. Fracassi,
  • Juliana G. G. Oliveira,
  • Isadora S. Ottani,
  • Sarah H. Lima,
  • Edmar A. Mazzi and
  • Taciana F. Gomes
  • + 7 authors

24 March 2020

Several previous studies on targeted food items using carbon and nitrogen stable isotope ratios in Brazil have revealed that many of the items investigated are adulterated; mislabeled or even fraud. Here, we present the first Brazilian isotopic basel...

  • Article
  • Open Access
21 Citations
4,521 Views
16 Pages

Oligomeric Procyanidin Nanoliposomes Prevent Melanogenesis and UV Radiation-Induced Skin Epithelial Cell (HFF-1) Damage

  • Yashu Chen,
  • Fenghong Huang,
  • David Julian McClements,
  • Bijun Xie,
  • Zhida Sun and
  • Qianchun Deng

24 March 2020

The potential protective effect of nanoliposomes loaded with lotus seedpod oligomeric procyanidin (LSOPC) against melanogenesis and skin damaging was investigated. Fluorescence spectroscopy showed that, after encapsulation, the LSOPC-nanoliposomes st...

  • Feature Paper
  • Article
  • Open Access
14 Citations
5,747 Views
14 Pages

A Self-Assembling NHC-Pd-Loaded Calixarene as a Potent Catalyst for the Suzuki-Miyaura Cross-Coupling Reaction in Water

  • Arnaud Peramo,
  • Ibrahim Abdellah,
  • Shannon Pecnard,
  • Julie Mougin,
  • Cyril Martini,
  • Patrick Couvreur,
  • Vincent Huc and
  • Didier Desmaële

24 March 2020

Nanoformulated calix[8]arenes functionalized with N-heterocyclic carbene (NHC)-palladium complexes were found to be efficient nano-reactors for Suzuki-Miyaura cross-coupling reactions of water soluble iodo- and bromoaryl compounds with cyclic triol a...

  • Article
  • Open Access
36 Citations
6,012 Views
16 Pages

Brassica incana Ten. (Brassicaceae): Phenolic Constituents, Antioxidant and Cytotoxic Properties of the Leaf and Flowering Top Extracts

  • Natalizia Miceli,
  • Emilia Cavò,
  • Monica Ragusa,
  • Francesco Cacciola,
  • Luigi Mondello,
  • Laura Dugo,
  • Rosaria Acquaviva,
  • Giuseppe Antonio Malfa,
  • Andreana Marino and
  • Manuela D’Arrigo
  • + 1 author

24 March 2020

Brassica incana Ten. is an edible plant belonging to the Brassicaceae family. In this work, the phenolic composition and the antioxidant and cytotoxic properties of the hydroalcoholic extracts obtained from the leaves and the flowering tops of B. inc...

  • Article
  • Open Access
7 Citations
4,510 Views
14 Pages

24 March 2020

(1) Background: Neospora caninum is a major cause of abortion in cattle and represents a veterinary health problem of great economic significance. In order to identify novel chemotherapeutic agents for the treatment of neosporosis, the Medicines for...

  • Article
  • Open Access
33 Citations
4,526 Views
17 Pages

Essential Oil-Based Design and Development of Novel Anti-Candida Azoles Formulation

  • Rania Hamdy,
  • Bahgat Fayed,
  • Alshaimaa M. Hamoda,
  • Mutasem Rawas-Qalaji,
  • Mohamed Haider and
  • Sameh S. M. Soliman

24 March 2020

Candida is the most common fungal class, causing both superficial and invasive diseases in humans. Although Candida albicans is the most common cause of fungal infections in humans, C. auris is a new emergent serious pathogen causing complications si...

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Molecules - ISSN 1420-3049