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Unusual Polyhydroxylated Steroids from the Starfish Anthenoides laevigatus, Collected off the Coastal Waters of Vietnam

1
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia
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Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
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Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
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School of Natural Sciences, Far Eastern Federal University, Sukhanova Str. 8, 690000 Vladivostok, Russia
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Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
*
Authors to whom correspondence should be addressed.
Academic Editor: Pavel S. Dmitrenok
Molecules 2020, 25(6), 1440; https://doi.org/10.3390/molecules25061440
Received: 13 February 2020 / Revised: 18 March 2020 / Accepted: 20 March 2020 / Published: 23 March 2020
Four new polyhydroxylated steroids 14 were isolated along with two previously known related steroids 5 and 6 from the methanolic extract of the starfish Anthenoides laevigatus collected off the coastal waters of Vietnam. Structures of new compounds were substantially elucidated by one-dimensional (1D) and two-dimensional (2D) NMR spectroscopy and HRESIMS techniques. Heptaol 1 and hexaol 2 contain the common 5α-cholestane skeleton, while hexaol 3 and heptaol 4 have the rare among starfish steroid compounds 5β-cholestane skeleton. Compounds 1, 5, and 6 do not show cytotoxic effects against normal JB6 Cl41 and cancer HT-29 and MDA-MB-231 cells, however they inhibit cell proliferation and colony formation of cancer HT-29 and MDA-MB-231 cells. View Full-Text
Keywords: polyhydroxylated steroids; NMR spectra; starfish; Anthenoides laevigatus; cytotoxicity; soft agar assay polyhydroxylated steroids; NMR spectra; starfish; Anthenoides laevigatus; cytotoxicity; soft agar assay
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Kicha, A.A.; Ha, D.T.; Malyarenko, T.V.; Kalinovsky, A.I.; Popov, R.S.; Malyarenko, O.S.; Thuy, T.T.T.; Long, P.Q.; Ha, N.T.T.; Ivanchina, N.V. Unusual Polyhydroxylated Steroids from the Starfish Anthenoides laevigatus, Collected off the Coastal Waters of Vietnam. Molecules 2020, 25, 1440.

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