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NMR-Based Plant Metabolomics in Nutraceutical Research: An Overview

Dipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche-DiSTABiF, Università degli Studi della Campania Luigi Vanvitelli, via Vivaldi 43, I-81100 Caserta, Italy
Department of Microbiology, Tumor and Cell Biology (MTC), Biomedicum B7, Karolinska Institutet, 17165 Stockholm, Sweden
Dipartimento di Biotecnologia Marina, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
Authors to whom correspondence should be addressed.
Molecules 2020, 25(6), 1444;
Received: 24 February 2020 / Revised: 15 March 2020 / Accepted: 20 March 2020 / Published: 23 March 2020
(This article belongs to the Special Issue Application of NMR Spectroscopy to Nutraceuticals Characterization)
Few topics are able to channel the interest of researchers, the public, and industries, like nutraceuticals. The ever-increasing demand of new compounds or new sources of known active compounds, along with the need of a better knowledge about their effectiveness, mode of action, safety, etc., led to a significant effort towards the development of analytical approaches able to answer the many questions related to this topic. Therefore, the application of cutting edges approaches to this area has been observed. Among these approaches, metabolomics is a key player. Herewith, the applications of NMR-based metabolomics to nutraceutical research are discussed: after a brief overview of the analytical workflow, the use of NMR-based metabolomics to the search for new compounds or new sources of known nutraceuticals are reviewed. Then, possible applications for quality control and nutraceutical optimization are suggested. Finally, the use of NMR-based metabolomics to study the impact of nutraceuticals on human metabolism is discussed. View Full-Text
Keywords: metabolomics; NMR; nutraceuticals metabolomics; NMR; nutraceuticals
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Valentino, G.; Graziani, V.; D’Abrosca, B.; Pacifico, S.; Fiorentino, A.; Scognamiglio, M. NMR-Based Plant Metabolomics in Nutraceutical Research: An Overview. Molecules 2020, 25, 1444.

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