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Open AccessArticle

Antinociceptive Effect of Hinokinin and Kaurenoic Acid Isolated from Aristolochia odoratissima L.

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Centro de Investigación Biomédica del Sur (CIBIS), Instituto Mexicano del Seguro Social (IMSS), Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, Mexico
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Universidad Juárez Autónoma de Tabasco, Carretera Cunduacán-Jalpa Km. 0.5, Cunduacán 86690, Tabasco, Mexico
*
Authors to whom correspondence should be addressed.
Academic Editor: Natalizia Miceli
Molecules 2020, 25(6), 1454; https://doi.org/10.3390/molecules25061454
Received: 28 February 2020 / Revised: 12 March 2020 / Accepted: 16 March 2020 / Published: 24 March 2020
Aristolochia odoratissima L. is employed for the treatment of pain and as an antidote against the poison of venomous animals in traditional medicine. However, reports have not been found, to our knowledge, about the evaluation of the antinociceptive activity of extracts nor about the presence of compounds associated with this activity. Thus, the purpose of this work was to evaluate the antinociceptive activity of extracts and compounds isolated from the stems of Artistolochia odoratissima L. The extracts were obtained with solvents of increasing polarity and the compounds were isolated and characterized by column chromatography, HPLC, and NMR. The antinociceptive activity was carried out by the formalin test in mice. Ethyl acetate (AoEA) and methanolic (AoM) extracts decreased the paw licking in both phases of the formalin test. The isolated compounds (kaurenoic acid and hinokinin) from AoEA showed the highest antinociceptive activity in both phases of the formalin test. These results confirmed the analgesic effect of this specie described in traditional medicine and provided a base for a novel analgesic agent. They also allowed an approach for the development of standardized plant extracts with isolated metabolites. View Full-Text
Keywords: Aristolochia odoratissima L.; antinociception; hinokinin; kaurenoic acid; formalin test Aristolochia odoratissima L.; antinociception; hinokinin; kaurenoic acid; formalin test
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Montiel-Ruiz, R.M.; Córdova-de la Cruz, M.; González-Cortázar, M.; Zamilpa, A.; Gómez-Rivera, A.; López-Rodríguez, R.; Lobato-García, C.E.; Blé-González, E.A. Antinociceptive Effect of Hinokinin and Kaurenoic Acid Isolated from Aristolochia odoratissima L.. Molecules 2020, 25, 1454.

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