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Oligomeric Procyanidin Nanoliposomes Prevent Melanogenesis and UV Radiation-Induced Skin Epithelial Cell (HFF-1) Damage

1
Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan 430062, China
2
Department of Food Science, University of Massachusetts Amherst, Amherst, MA 01003, USA
3
Natural Product Laboratory, Department of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(6), 1458; https://doi.org/10.3390/molecules25061458
Received: 19 February 2020 / Revised: 9 March 2020 / Accepted: 12 March 2020 / Published: 24 March 2020
The potential protective effect of nanoliposomes loaded with lotus seedpod oligomeric procyanidin (LSOPC) against melanogenesis and skin damaging was investigated. Fluorescence spectroscopy showed that, after encapsulation, the LSOPC-nanoliposomes still possessed strong inhibitory effects against melanogenesis, reducing the activity of both monophenolase and diphenolase. Molecular docking indicated that LSOPC could generate intense interactive configuration with tyrosinase through arene–H, arene–arene, and hydrophobic interaction. An ultraviolet radiated cell-culture model (human foreskin fibroblast cell (HFF-1)) was used to determine the protective effects of the LSOPC-nanoliposomes against skin aging and damage. Results showed that LSOPC-nanoliposomes exerted the highest protective effects against both ultraviolet B (UVB) and ultraviolet A (UVA) irradiation groups compared with non-encapsulated LSOPC and a control (vitamin C). Superoxide dismutase (SOD) and malonaldehyde (MDA) assays demonstrated the protection mechanism may be related to the anti-photooxidation activity of the procyanidin. Furthermore, a hydroxyproline assay suggested that the LSOPC-nanoliposomes had a strong protective effect against collagen degradation and/or synthesis after UVA irradiation. View Full-Text
Keywords: lotus seedpod oligomeric procyanidin; nanoliposomes; melanogenesis; UV-induced damage; skin aging lotus seedpod oligomeric procyanidin; nanoliposomes; melanogenesis; UV-induced damage; skin aging
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MDPI and ACS Style

Chen, Y.; Huang, F.; McClements, D.J.; Xie, B.; Sun, Z.; Deng, Q. Oligomeric Procyanidin Nanoliposomes Prevent Melanogenesis and UV Radiation-Induced Skin Epithelial Cell (HFF-1) Damage. Molecules 2020, 25, 1458.

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