Animal venom has been gaining traction as a potential source of therapeutics for various diseases. Spiders encompass a wide variety of venom-producing species, of which tarantulas of the family Theraphosidae are widely known across the globe. Researc...
Envenomation by the Indian ornamental tarantula (Poecilotheria regalis) is medically relevant to humans, both in its native India and worldwide, where they are kept as pets. Muscle-related symptoms such as cramps and pain are commonly reported in hum...
Huwentoxin-XI (HWTX-XI) is a 55-amino acid peptide belonging to the family of spider Kuntiz-type toxins (KTTs), isolated from the venom of the Chinese tarantula Ornithoctonus huwena. Under whole-cell voltage-clamp conditions, HWTX-XI was found to blo...
Inhibition of T-type calcium channels (CaV3) prevents development of diseases related to cardiovascular and nerve systems. Further, knockout animal studies have revealed that some diseases are mediated by specific subtypes of CaV3. However, subtype-s...
Theraphosid spiders (tarantulas) are venomous arthropods found in most tropical and subtropical regions of the world. Tarantula venoms are a complex cocktail of toxins with potential use as pharmacological tools, drugs and bioinsecticides. Although n...
Animal venoms are promising sources of novel drug leads, but their translational potential is hampered by the low success rate of earlier biodiscovery programs, in part reflecting the narrow selection of targets for investigation. To increase the num...
Tarantulas represent a highly diverse taxonomic group and play a crucial role in ecosystems. To gain a deeper understanding of the evolutionary relationships within the family Theraphosidae, in this study, we characterized the mitochondrial genome (m...
Spider-derived venoms are a rich source of cystine knot peptides with immense therapeutic potential. Many of these peptides exert unique biological activities through the modulation of ion channels, including of human voltage-gated sodium (NaV1.1&nda...
The increasing demand for sustainable construction materials has motivated the optimization of mortar mix designs to reduce cement consumption and its environmental impact while maintaining adequate mechanical performance. This study develops a machi...
Parasitoid wasps represent the plurality of venomous animals, but have received extremely little research in proportion to this taxonomic diversity. The lion’s share of investigation into insect venoms has focused on eusocial hymenopterans, but even...
Edible insects are becoming increasingly popular as protein alternatives to traditional animal-based products. As such, information on their elemental composition is important to ensure they are safe for human consumption. This article describes the...
A review of the properties of the Tarantula Nebula (30 Doradus) in the Large Magellanic Cloud is presented, primarily from the perspective of its massive star content. The proximity of the Tarantula and its accessibility to X-ray through radio observ...
The durability of concrete is compromised by early-age cracking, which provides a pathway for harmful ions and water to penetrate the material. Early-age cracking, however, is most commonly caused by concrete shrinkage. This study investigates strate...
This paper firstly presents the design and modeling of a quadruped wheeled robot named Tarantula. It has four legs each having four degrees of freedom with a proximal end attached to the trunk and the wheels for locomotion connected at the distal end...
Spider venoms represent an original source of novel compounds with therapeutic and agrochemical potential. Whereas most of the research efforts have focused on large mygalomorph spiders, araneomorph spiders are equally promising but require more sens...
We describe the first predation record of an undescribed adult male tarantula from the genus Euathlus in a juvenile austral thrush (Turdus falcklandii Quoy and Gaimard, 1824) (Aves: Turdidae) in central Chile. The precise moment of predation was not...
Effective control of diseases transmitted by Aedes aegypti is primarily achieved through vector control by chemical insecticides. However, the emergence of insecticide resistance in A. aegypti undermines current control efforts. Arachnid venoms...
Voltage-gated sodium (NaV) channels are responsible for propagating action potentials in excitable cells. NaV1.7 plays a crucial role in the human pain signalling pathway and it is an important therapeutic target for treatment of chronic pain. Numero...
Thrixopelma nadineae sp. nov. is described from Loja, Ecuador, based on the male, which possesses distinctive palpal bulb, metatarsal and tibial apophysis morphology. The new species represents the second species of Thrixopelma to be recorded from Ec...
Herein, we redescribe Neostenotarsus guianensis (Caporiacco, 1954) nearly seven decades after its original description. In the original description of Neostenotarsus scissistylus Tesmoingt & Schmidt, 2002, we found characters incongruent with N. ...
The hitherto unknown female of the theraphosine Spinosatibiapalpus trinitatis (Pocock, 1903) is herein described based on the paralectotype series of the schismatotheline Neoholothele incei (F. O. Pickard-Cambridge, 1899) housed in the collections of...
Spider venoms constitute a trove of novel peptides with biotechnological interest. Paucity of next-generation-sequencing (NGS) data generation has led to a description of less than 1% of these peptides. Increasing evidence supports the underestimatio...
The article starts from Gilles Deleuze’s assumption of film being a philosophy in its own right and applies it to the horror genre. It reads Stanley Cavell’s concept of genre, Timothy Jay Walker’s work on the Horror of the Other (1)...
The voltage-gated sodium channel NaV1.7 is an important target for drug development due to its role in pain perception. Recombinant expression of full-length channels and their use for biophysical characterization of interactions with potential drug...
Spider venoms constitute incredibly diverse libraries of compounds, many of which are involved in prey capture and defence. Polyamines are often prevalent in the venom and target ionotropic glutamate receptors. Here we show that a novel spider polyam...
Gomesin is a cationic antimicrobial peptide which is isolated from the haemocytes of the Brazilian tarantula Acanthoscurria gomesiana and can be produced chemically by Fmoc solid-phase peptide synthesis. Gomesin exhibits a range of biological activit...
Chitin, as a fundamental polysaccharide in invertebrate skeletons, continues to be actively investigated, especially with respect to new sources and the development of effective methods for its extraction. Recent attention has been focused on marine...
The type material of Xenesthis colombiana Simon, 1891, X. immanis Ausserer, 1875, and X. monstrosa Pocock, 1903, are redescribed, with additional specimens of X. colombiana recorded. A neotype is designated for Xenesthis intermedia Schiapelli and Ger...
Inhibitor cystine knot (ICK) peptides are knotted peptides with three intramolecular disulfide bonds that affect several types of ion channels. Some are proteolytically stable and are promising scaffolds for drug development. GTx1-15 is an ICK peptid...
With the launch of JWST and the upcoming installation of extremely large telescopes, the first galaxies in our Universe will finally be revealed. Their light will be dominated by massive stars, which peak in in the ultra-violet (UV) part of the elect...
The inspection and maintenance of drains with varying heights necessitates a drain mapping robot with trained labour to maintain community hygiene and prevent the spread of diseases. For adapting to level changes and navigating in the narrow confined...
Spider venom is a novel source of disulfide-rich peptides with potent and selective activity at voltage-gated sodium channels (NaV). Here, we describe the discovery of μ-theraphotoxin-Pme1a and μ/δ-theraphotoxin-Pme2a, two novel peptides...
This review summarises the current knowledge of Gomesin (Gm), an 18-residue long, cationic anti-microbial peptide originally isolated from the haemocytes of the Brazilian tarantula Acanthoscurria gomesiana. The peptide shows potent cytotoxic activity...
The automatic localization of software faults plays a critical role in assisting software professionals in fixing problems quickly. Despite various existing models for fault tolerance based on static features, localization is still challenging. By co...
Pain is a natural bioassay for detecting and quantifying biological activities of venoms. The painfulness of stings delivered by ants, wasps, and bees can be easily measured in the field or lab using the stinging insect pain scale that rates the pain...
Lightweight aggregate concrete is known for its potential to decrease overall building load and cost. Aero Aggregates’ Aerolite is a foamed glass aggregate (FGA) available in seven different sizes which has the potential to replace normal weigh...
Conotoxins are disulfide-rich peptides found in the venom of cone snails. Due to their exquisite potency and high selectivity for a wide range of voltage and ligand gated ion channels they are attractive drug leads in neuropharmacology. Recently, con...
Many animal species can produce venom for defense, predation, and competition. The venom usually contains diverse peptide and protein toxins, including neurotoxins, proteolytic enzymes, protease inhibitors, and allergens. Some drugs for cancer, neuro...
Phlotoxin-1 (PhlTx1) is a peptide previously identified in tarantula venom (Phlogius species) that belongs to the inhibitory cysteine-knot (ICK) toxin family. Like many ICK-based spider toxins, the synthesis of PhlTx1 appears particularly challenging...
Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels largely expressed in the nervous system of rodents and humans. At least six isoforms (ASIC1a, 1b, 2a, 2b, 3 and 4) associate into homotrimers or heterotrimers to form...
Understanding how children and adolescents perceive zoo animal welfare provides insights into public views on captive conditions. This study used a mixed-methods approach to investigate these perceptions. A total of 254 participants (aged 7–18)...
Tarantulas (family Theraphosidae) are ecologically significant invertebrate predators in terrestrial ecosystems, but many species face threats from habitat fragmentation and unsustainable collection for the international pet trade. Brachypelma albice...
Although known for their potent venom and ability to prey upon both invertebrate and vertebrate species, the Barychelidae spider family has been entirely neglected by toxinologists. In striking contrast, the sister family Theraphosidae (commonly know...
Many chemical insecticides are becoming less efficacious due to rising resistance in pest species, which has created much interest in the development of new, eco-friendly bioinsecticides. Since insects are the primary prey of most spiders, their veno...
Background: Antimicrobial peptides are generally considered promising drug candidates for combating resistant bacterial infections. However, the selectivity of their action may vary significantly. Natural gomesin, isolated from haemocytes of the tara...
In the original publication [...]