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209 Results Found

  • Article
  • Open Access
3,755 Views
16 Pages

30 June 2023

This paper addresses the grammatical challenges associated with the development of clause complexity, focusing on the performance of a group of monolingual Spanish-speaking schoolchildren with Specific Language Impairment/Developmental Language Disor...

  • Article
  • Open Access
2 Citations
1,041 Views
16 Pages

The Link Between the Applied Visual Strategy When Copying the Rey–Osterrieth Complex Figure and the Language Abilities in Children with Specific Language Impairment

  • Ivana Milanović,
  • Milena Paštar,
  • Saška Žunić,
  • Maša Marisavljević,
  • Mile Vuković,
  • Vladimir Janjić,
  • Milan Đorđić and
  • Miško Subotić

Background/Objectives: Although specific language impairment (SLI) was thought to be a language impairment, recent studies suggest that it is also associated with domain-general and nonverbal deficits such as deficits in nonverbal working memory, vis...

  • Article
  • Open Access
1 Citations
1,429 Views
24 Pages

Brain Complexity and Parametrization of Power Spectral Density in Children with Specific Language Impairment

  • Brenda Y. Angulo-Ruiz,
  • Elena I. Rodríguez-Martínez,
  • Francisco J. Ruiz-Martínez,
  • Ana Gómez-Treviño,
  • Vanesa Muñoz,
  • Sheyla Andalia Crespo and
  • Carlos M. Gómez

28 May 2025

This study examined spontaneous activity in children aged 3–11 years with specific language impairment (SLI) using an electroencephalogram (EEG). We compared SLI-diagnosed children with a normo-development group (ND). The signal complexity, mul...

  • Article
  • Open Access
3 Citations
2,376 Views
18 Pages

28 June 2023

Individuals with specific language impairment (SLI) struggle with language acquisition despite average non-verbal intelligence and otherwise typical development. One SLI account focuses on grammar acquisition delay. The current study aimed to detect...

  • Article
  • Open Access
4 Citations
2,855 Views
13 Pages

Assessment of Executive Functions in Children with Sensorineural Hearing Loss and in Children with Specific Language Impairment: Preliminary Reports

  • Maria Lauriello,
  • Giulia Mazzotta,
  • Antonella Mattei,
  • Ilaria Mulieri,
  • Alessandra Fioretti,
  • Enzo Iacomino and
  • Alberto Eibenstein

Executive functions (EFs) are related abilities, associated with the frontal lobes functions, that allow individuals to modify behavioral patterns when they become unsatisfactory. The aim of this study was to assess EFs in children with sensorineural...

  • Article
  • Open Access
1 Citations
1,395 Views
9 Pages

Genome-Wide Mapping of Consanguineous Families Confirms Previously Implicated Gene Loci and Suggests New Loci in Specific Language Impairment (SLI)

  • Adnan Yousaf,
  • Huma Hafeez,
  • Muhammad Asim Raza Basra,
  • Mabel L. Rice,
  • Muhammad Hashim Raza and
  • Muhammad Imran Shabbir

30 August 2024

Specific language impairment (SLI) is a developmental disorder with substantial genetic contributions. A genome-wide linkage analysis and homozygosity mapping were performed in five consanguineous families from Pakistan. The highest LOD scores of 2.4...

  • Article
  • Open Access
16 Citations
4,476 Views
20 Pages

30 December 2021

Specific language impairment (SLI) is a common neurodevelopmental disorder (NDD) that displays high heritability estimates. Genetic studies have identified several loci, but the molecular basis of SLI remains unclear. With the aim to better understan...

  • Review
  • Open Access
32 Citations
6,255 Views
20 Pages

Sentence Repetition Tasks to Detect and Prevent Language Difficulties: A Scoping Review

  • Irene Rujas,
  • Sonia Mariscal,
  • Eva Murillo and
  • Miguel Lázaro

Sentence repetition tasks (SRTs) have been widely used in language development research for decades. In recent years, there has been increasing interest in studying performance in SRTs as a clinical marker for language impairment. What are the charac...

  • Article
  • Open Access
1 Citations
1,932 Views
16 Pages

Intranasal Immunotherapy with M2 Macrophage Secretome Ameliorates Language Impairments and Autistic-like Behavior in Children

  • Ekaterina Ya. Shevela,
  • Tatiana A. Loginova,
  • Alexandr S. Munkuev,
  • Tatiana E. Volskaya,
  • Svetlana A. Sergeeva,
  • Ivan M. Rashchupkin,
  • Marina Yu. Kafanova,
  • Valentina G. Degtyareva,
  • Anastasia V. Sosnovskaya and
  • Alexandr A. Ostanin
  • + 1 author

24 May 2024

Background/Objectives: The intranasal delivery of various neurotropic substances is considered a new attractive therapeutic approach for treating neuropathologies associated with neuroinflammation and altered regeneration. Specific language impairmen...

  • Article
  • Open Access
12 Citations
4,511 Views
17 Pages

Clitic Production in Bilingual Children: When Exposure Matters

  • Maria Vender,
  • Denis Delfitto and
  • Chiara Melloni

The aim of this work is to investigate how bilingual children perform with respect to monolingual children in a task eliciting direct object clitic pronouns in Italian. Clitic production is considered a good clinical marker for Italian monolingual ch...

  • Review
  • Open Access
33 Citations
12,810 Views
25 Pages

Reading and Language Disorders: The Importance of Both Quantity and Quality

  • Dianne F. Newbury,
  • Anthony P. Monaco and
  • Silvia Paracchini

4 April 2014

Reading and language disorders are common childhood conditions that often co-occur with each other and with other neurodevelopmental impairments. There is strong evidence that disorders, such as dyslexia and Specific Language Impairment (SLI), have...

  • Case Report
  • Open Access
523 Views
12 Pages

Auditory Electrophysiology of an Adolescent with Both Language and Learning Disorders

  • Aparecido J. Couto Soares,
  • Adriana Neves de Andrade,
  • Piotr Henryk Skarzynki,
  • Claudia Berlim de Mello and
  • Milaine Dominici Sanfins

2 November 2025

Background and Clinical Significance: developmental language disorder (DLD) and specific learning disorder (SLD) may coexist, resulting in significantly broader impairments to oral and written language skills. Understanding the neurobiological basis...

  • Feature Paper
  • Article
  • Open Access
6 Citations
3,030 Views
12 Pages

Reevaluation of Serum Arylesterase Activity in Neurodevelopmental Disorders

  • Ignazio Stefano Piras,
  • Stefano Gabriele,
  • Laura Altieri,
  • Federica Lombardi,
  • Roberto Sacco,
  • Carla Lintas,
  • Barbara Manzi,
  • Paolo Curatolo,
  • Maria Nobile and
  • Catia Rigoletto
  • + 2 authors

22 January 2021

Organophosphate compounds (OPs) interfere with neurodevelopment and are neurotoxic for humans and animals. They are first biotransformed to the more toxic oxon form, and then hydrolyzed to specific metabolites by the enzyme paraoxonase/arylesterase,...

  • Article
  • Open Access
3 Citations
2,133 Views
18 Pages

Comparing Anxiety Levels during the COVID-19 Pandemic among Mothers of Children with and without Neurodevelopmental Disorders

  • Ivana Bogavac,
  • Ljiljana Jeličić,
  • Jelena Đorđević,
  • Ivana Veselinović,
  • Maša Marisavljević and
  • Miško Subotić

27 July 2023

The COVID-19 pandemic undoubtedly burdened families, perhaps even more for parents of children with neurodevelopmental disabilities. This research aims to determine the anxiety levels in mothers of children with neurodevelopmental disorders (autism s...

  • Article
  • Open Access
12 Citations
6,965 Views
11 Pages

Feasibility and Effectiveness of Speech Intervention Implemented with a Virtual Reality System in Children with Developmental Language Disorders: A Pilot Randomized Control Trial

  • Irene Cappadona,
  • Augusto Ielo,
  • Margherita La Fauci,
  • Maria Tresoldi,
  • Carmela Settimo,
  • Maria Cristina De Cola,
  • Rosalia Muratore,
  • Carmela De Domenico,
  • Marcella Di Cara and
  • Francesco Corallo
  • + 4 authors

1 August 2023

Language disorders are characterized by impairments in verbal expression/understanding, including difficulties with one or more language components. The Virtual Reality Rehabilitation System (VRRS) is a bioelectromedical device equipped with exercise...

  • Article
  • Open Access
6 Citations
6,547 Views
14 Pages

Exploring AI Technology in Grammar Performance Testing for Children with Learning Disabilities

  • Dimitra V. Katsarou,
  • Evangelos Mantsos,
  • Soultana Papadopoulou,
  • Maria Sofologi,
  • Efthymia Efthymiou,
  • Ilias Vasileiou,
  • Kalliopi Megari,
  • Maria Theodoratou and
  • Georgios A. Kougioumtzis

11 March 2025

The study explores the application of artificial intelligence (AI) in addressing grammar challenges among children with learning disabilities, aiming to assess the efficacy of an AI-driven tool for personalized interventions. A sample of 100 children...

  • Article
  • Open Access
16 Citations
6,661 Views
30 Pages

Consistency of a Nonword Repetition Task to Discriminate Children with and without Developmental Language Disorder in Catalan–Spanish and European Portuguese Speaking Children

  • Nadia Ahufinger,
  • Amy Berglund-Barraza,
  • Anabela Cruz-Santos,
  • Laura Ferinu,
  • Llorenç Andreu,
  • Mònica Sanz-Torrent and
  • Julia L. Evans

26 January 2021

Nonword repetition has been proposed as a diagnostic marker of developmental language disorder (DLD); however, the inconsistency in the ability of nonword repetition tasks (NRT) to identify children with DLD raises significant questions regarding its...

  • Article
  • Open Access
32 Citations
11,057 Views
18 Pages

Behavioral, Emotional and School Adjustment in Adolescents with and without Developmental Language Disorder (DLD) Is Related to Family Involvement

  • Mario Valera-Pozo,
  • Daniel Adrover-Roig,
  • Josep A. Pérez-Castelló,
  • Victor A. Sanchez-Azanza and
  • Eva Aguilar-Mediavilla

Developmental language disorder (DLD) refers to a language delay in the absence of other underlying causes. Individuals with DLD can also present other problems related to behavioral, scholarly, and emotional aspects of their daily lives because of t...

  • Article
  • Open Access
5 Citations
3,119 Views
16 Pages

The linguistic profile of bilingual children is known to show areas of overlap with that of children affected by Developmental Language Disorder (DLD), creating a need to differentiate the profiles and provide clinicians with tools to evaluate biling...

  • Review
  • Open Access
34 Citations
15,011 Views
17 Pages

The Genetic and Molecular Basis of Developmental Language Disorder: A Review

  • Hayley S. Mountford,
  • Ruth Braden,
  • Dianne F. Newbury and
  • Angela T. Morgan

20 April 2022

Language disorders are highly heritable and are influenced by complex interactions between genetic and environmental factors. Despite more than twenty years of research, we still lack critical understanding of the biological underpinnings of language...

  • Article
  • Open Access
5 Citations
3,597 Views
21 Pages

Syntactic Gender Agreement Processing on Direct-Object Clitics by Spanish-Speaking Children with Developmental Language Disorder: Evidence from ERP

  • Paloma Roa-Rojas,
  • John Grinstead,
  • Juan Silva-Pereyra,
  • Thalía Fernández and
  • Mario Rodríguez-Camacho

25 February 2021

Children with developmental language disorder (DLD) have a psycholinguistic profile evincing multiple syntactic processing impairments. Spanish-speaking children with DLD struggle with gender agreement on clitics; however, the existing evidence comes...

  • Article
  • Open Access
74 Citations
16,285 Views
29 Pages

Language and communication deficits characterize both autism spectrum disorder and developmental language disorder, and the possibility of there being a common profile of these is a matter of tireless debate in the research community. This experiment...

  • Case Report
  • Open Access
13 Citations
4,308 Views
14 Pages

“Hard to Say, Hard to Understand, Hard to Live”: Possible Associations between Neurologic Language Impairments and Suicide Risk

  • Alessandra Costanza,
  • Andrea Amerio,
  • Andrea Aguglia,
  • Luca Magnani,
  • Gianluca Serafini,
  • Mario Amore,
  • Roberto Merli,
  • Julia Ambrosetti,
  • Guido Bondolfi and
  • Lisa Marzano
  • + 1 author

30 November 2021

In clinical practice, patients with language impairments often exhibit suicidal ideation (SI) and suicidal behavior (SB, covering the entire range from suicide attempts, SA, to completed suicides). However, only few studies exist regarding this subje...

  • Article
  • Open Access
4 Citations
3,638 Views
17 Pages

MoCA Domain-Specific Pattern of Cognitive Impairment in Stroke Patients Attending Intensive Inpatient Rehabilitation: A Prospective Study

  • Benedetta Basagni,
  • Serena Malloggi,
  • Cristina Polito,
  • Leonardo Pellicciari,
  • Silvia Campagnini,
  • Silvia Pancani,
  • Andrea Mannini,
  • Paola Gemignani,
  • Emilia Salvadori and
  • Sara Marignani
  • + 6 authors

9 January 2024

A domain-specific perspective to cognitive functioning in stroke patients may predict their cognitive recovery over time and target stroke rehabilitation intervention. However, data about domain-specific cognitive impairment after stroke are still sc...

  • Case Report
  • Open Access
7 Citations
3,715 Views
12 Pages

Characterization of Speech and Language Phenotype in GLUT1DS

  • Martina Paola Zanaboni,
  • Ludovica Pasca,
  • Barbara Valeria Villa,
  • Antonella Faggio,
  • Serena Grumi,
  • Livio Provenzi,
  • Costanza Varesio and
  • Valentina De Giorgis

27 April 2021

Background: To analyze the oral motor, speech and language phenotype in a sample of pediatric patients with GLUT 1 transporter deficiency syndrome (GLUT1DS). Methods: eight Italian-speaking children with GLUT1DS (aged 4.6–15.4 years) in stable treatm...

  • Article
  • Open Access
5 Citations
3,248 Views
13 Pages

22 December 2024

Background: Cognitive impairment poses a significant global health challenge, emphasizing the critical need for early detection and intervention. Traditional diagnostics like neuroimaging and clinical evaluations are often subjective, costly, and ina...

  • Article
  • Open Access
9 Citations
3,853 Views
24 Pages

Defining Hypoperfusion in Chronic Aphasia: An Individualized Thresholding Approach

  • Noelle T. Abbott,
  • Carolyn J. Baker,
  • Conan Chen,
  • Thomas T. Liu and
  • Tracy E. Love

Within the aphasia literature, it is common to link location of lesioned brain tissue to specific patterns of language impairment. This has provided valuable insight into the relationship between brain structure and function, but it does not capture...

  • Article
  • Open Access
3 Citations
4,882 Views
19 Pages

Background: Parkinson’s disease [PD] is associated with reduced motor and cognitive initiation, and decreased goal-directed behavior including language generation. The current study investigated a novel goal intervention for language generation impai...

  • Brief Report
  • Open Access
1,806 Views
10 Pages

Selective Alteration of the Left Arcuate Fasciculus in Two Patients Affected by Creatine Transporter Deficiency

  • Maurizio Balestrino,
  • Enrico Adriano,
  • Paolo Alessandro Alì and
  • Matteo Pardini

(1) Background: In hereditary creatine transporter deficiency (CTD), there is an absence of creatine in the brain and neurological symptoms are present, including severe language impairment. However, the pathological changes caused by creatine defici...

  • Article
  • Open Access
15 Citations
2,480 Views
11 Pages

8 October 2022

Aiming to examine whether specific motor signs are associated with worse performance in specific cognitive domains among cognitively unimpaired (CU) individuals, we performed a cross-sectional analysis of data from the baseline evaluations of older,...

  • Article
  • Open Access
57 Citations
19,576 Views
17 Pages

Language Problems and ADHD Symptoms: How Specific Are the Links?

  • Erin Hawkins,
  • Susan Gathercole,
  • Duncan Astle,
  • The CALM Team and
  • Joni Holmes

21 October 2016

Symptoms of inattention and hyperactivity frequently co-occur with language difficulties in both clinical and community samples. We explore the specificity and strength of these associations in a heterogeneous sample of 254 children aged 5 to 15 year...

  • Article
  • Open Access
4 Citations
2,850 Views
16 Pages

27 February 2025

Background: Preventing neurodevelopmental impairment after extremely preterm birth remains challenging. While breast milk feeding is linked to better neurodevelopment, the underlying mechanisms are unclear. This study explored the association between...

  • Systematic Review
  • Open Access
611 Views
24 Pages

Electrical Cortical Stimulation for Language Mapping in Epilepsy Surgery—A Systematic Review

  • Honglin Zhu,
  • Efthymia Korona,
  • Sepehr Shirani,
  • Fatemeh Samadian,
  • Gonzalo Alarcon,
  • Antonio Valentin and
  • Ioannis Stavropoulos

26 November 2025

Background: Language mapping is a critical component of epilepsy surgery, as postoperative language deficits can significantly impact patients’ quality of life. Electrical stimulation mapping has emerged as a valuable tool for identifying eloqu...

  • Article
  • Open Access
603 Views
17 Pages

Targeting Executive Function and Language Impairments with tACS Combined with Behavioral Intervention in Primary Progressive Aphasia: A Case-Series, Pilot Investigation

  • Kyriaki Neophytou,
  • Dimitrios S. Kasselimis,
  • Georgia Angelopoulou,
  • Areti Deligiannaki,
  • Rafailia Bourtsoukli,
  • Eleni Peristeri,
  • Vasilina Spanou,
  • Sokratis G. Papageorgiou,
  • Vasilios C. Constantinides and
  • Constantin Potagas
  • + 1 author

7 November 2025

Background/Objectives: Executive function (EF) impairments are found in a variety of neurodegenerative disorders, including in Primary Progressive Aphasia (PPA), which is primarily characterized by language impairments. The goal of this preliminary i...

  • Article
  • Open Access
1 Citations
2,525 Views
12 Pages

Olfactory Function as a Potential Predictor of Cognitive Impairment in Men and Women

  • Carla Masala,
  • Francesco Loy,
  • Ilenia Pinna,
  • Nicoletta Aurora Manis,
  • Tommaso Ercoli and
  • Paolo Solla

5 July 2024

Background: Different previous studies indicated olfactory function as a predictor of several types of cognitive impairment, in particular related to neurodegenerative disease. However, scanty data are available on the role of odor threshold (OT), od...

  • Article
  • Open Access
1,059 Views
25 Pages

Assessing Language Skills in Children Aged 4 to 6 Years with Autism Spectrum Disorder: A Prospective Study

  • Jade Mériaux,
  • Sandrine Foin,
  • Abdessadek El Ahmadi,
  • Christine Assaiante and
  • Pascale Colé

24 November 2025

Background/Objectives: Language impairments are highly prevalent in children with Autism Spectrum Disorder (ASD). In preschoolers (3–6 years), language development predicts future social outcomes. Despite the availability of standardized tests...

  • Case Report
  • Open Access
2,638 Views
24 Pages

25 July 2025

Selective Mutism (SM) is a childhood anxiety disorder characterized by the persistent inability to speak in specific social settings while being able to speak freely in more comfortable environments, such as at home with family. This condition often...

  • Article
  • Open Access
5 Citations
2,826 Views
18 Pages

Morpho-Syntactic Deficit in Children with Cochlear Implant: Consequence of Hearing Loss or Concomitant Impairment to the Language System?

  • Erika Benassi,
  • Sonia Boria,
  • Maria Teresa Berghenti,
  • Michela Camia,
  • Maristella Scorza and
  • Giuseppe Cossu

Background: Among implanted children with similar duration of auditory deprivation and clinical history, the morpho-syntactic skills remain highly variable, suggesting that other fundamental factors may determine the linguistic outcomes of these chil...

  • Systematic Review
  • Open Access
2 Citations
1,488 Views
23 Pages

Background: Griffiths III is a child-friendly and play-oriented direct gold-standard measure of a 0–6-year-old child’s developmental profile. It is a measure that helps practitioners in detecting the weaknesses in children who have an inc...

  • Article
  • Open Access
7 Citations
2,045 Views
8 Pages

The coronavirus disease (COVID-19) pandemic has led our society to lead a life different than before. People, including those with disabilities, have come to rely on information from the Internet. However, there is a lack of empirical studies on the...

  • Article
  • Open Access
7 Citations
3,070 Views
17 Pages

Visual Implicit Learning Abilities in Infants at Familial Risk for Language and Learning Impairments

  • Roberta Bettoni,
  • Chiara Cantiani,
  • Valentina Riva,
  • Massimo Molteni,
  • Viola Macchi Cassia and
  • Hermann Bulf

The ability of infants to track transitional probabilities (Statistical Learning—SL) and to extract and generalize high-order rules (Rule Learning—RL) from sequences of items have been proposed as being pivotal for the acquisition of lang...

  • Article
  • Open Access
2,461 Views
23 Pages

22 November 2024

Background: Educational professionals face significant challenges in determining the most appropriate educational placement for each child with ASD, which is a major concern for their parents. The purpose of this paper is to identify the factors in t...

  • Article
  • Open Access
3 Citations
3,428 Views
13 Pages

Deep Learning-Based End-to-End Language Development Screening for Children Using Linguistic Knowledge

  • Byoung-Doo Oh,
  • Yoon-Kyoung Lee,
  • Jong-Dae Kim,
  • Chan-Young Park and
  • Yu-Seop Kim

6 May 2022

Language development is inextricably linked to the development of fundamental human abilities. A language problem can result from abnormal language development in childhood, which has a severe impact on other elements of life. As a result, early trea...

  • Article
  • Open Access
1 Citations
1,883 Views
16 Pages

29 November 2024

Background/Objectives: Specific tests for the assessment of language development and language skills in deaf children are scarce. For this reason, parent inventories and/or standardized tests that are reliable and valid in the hearing population are...

  • Article
  • Open Access
1 Citations
1,870 Views
12 Pages

Introduction. Primary progressive aphasia (PPA) is a clinical syndrome characterized by a progressive deterioration in language and speech. It is classified into three variants based on symptom patterns: logopenic, semantic, and non-fluent. Due to th...

  • Article
  • Open Access
8 Citations
6,924 Views
45 Pages

27 March 2013

Although amnesic H.M. typically could not recall where or when he met someone, he could recall their topics of conversation after long interference-filled delays, suggesting impaired encoding for some categories of novel events but not others. Simila...

  • Article
  • Open Access
3 Citations
5,243 Views
20 Pages

Null Subject Occurrence in Monolingual Spanish SLI: A Discriminant Function Analysis

  • John Grinstead,
  • Paij Lintz,
  • Amy Pratt,
  • Mariana Vega-Mendoza,
  • Juliana De la Mora,
  • Myriam Cantú-Sánchez and
  • Blanca Flores-Avalos

Background: Child Spanish-speakers appear to use more null subjects than do adults. Null subject use, like the use of tense marking, is sensitive to discourse-pragmatics. Because tense marking has been used to identify child Spanish-speakers with spe...

  • Article
  • Open Access
7 Citations
4,693 Views
21 Pages

15 August 2022

This study evaluates whether the short version of the German LITMUS quasi-universal nonword repetition task (LITMUS-QU-NWR) can be used as an index test for monolingual and early second language learners (eL2) of German aged 8 to 10 years. The NWR ta...

  • Article
  • Open Access
13 Citations
4,913 Views
9 Pages

Disability-Specific Associations with Child Health and Functioning

  • Ko Ling Chan,
  • Camilla K. M. Lo,
  • Frederick K. Ho and
  • Patrick Ip

This study examined the health profile of children with different types of disabilities and explored the disability-specific associations with various types of health and functioning using a large nonclinical sample of children. A cross-sectional sch...

  • Article
  • Open Access
2,029 Views
21 Pages

9 June 2025

Despite the growing number of bilinguals worldwide, research on how bilingualism influences grammatical development in children with learning disabilities remains limited. This may be due to challenges in assessing language in these children, given t...

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