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898 Results Found

  • Article
  • Open Access
3 Citations
1,495 Views
22 Pages

Proteins and polyphenols are important components in barley malt. During the roasting process of barley malt, proteins and polyphenols interact and influence each other, ultimately altering the nutritional profile and functional properties of barley...

  • Review
  • Open Access
1,921 Views
25 Pages

17 September 2025

Metabolic illnesses such as obesity, type 2 diabetes and hyperuricemia are becoming more common, driving intensified research into nutritional interventions through targeted dietary modifications as a primary preventive strategy. The apparent fluctua...

  • Review
  • Open Access
235 Views
40 Pages

Recent Insights into Protein-Polyphenol Complexes: Molecular Mechanisms, Processing Technologies, Synergistic Bioactivities, and Food Applications

  • Hoang Duy Huynh,
  • Thanh Huong Tran Thi,
  • Thanh Xuan Tran Thi,
  • Parushi Nargotra,
  • Hui-Min David Wang,
  • Yung-Chuan Liu and
  • Chia-Hung Kuo

13 January 2026

Modifying proteins through grafting with polyphenols has received much attention recently due to its immense application potential. This stems from the formation of protein-polyphenol complexes, altering the structural and functional properties of th...

  • Article
  • Open Access
15 Citations
3,600 Views
20 Pages

Antioxidant and Anti-Aging Properties of Polyphenol–Polysaccharide Complex Extract from Hizikia fusiforme

  • Shangkun Li,
  • Yunhai He,
  • Saiyi Zhong,
  • Yutong Li,
  • Yuan Di,
  • Qiukuan Wang,
  • Dandan Ren,
  • Shu Liu,
  • Di Li and
  • Fangjie Cao

10 October 2023

Hizikia fusiforme has a long history of consumption and medicinal use in China. It has been found that natural plants containing polyphenol–polysaccharide complexes have better activity compared with polyphenols and polysaccharides. Therefore,...

  • Article
  • Open Access
13 Citations
2,967 Views
13 Pages

13 October 2023

Interactions between food components have a positive impact in the field of food science. In this study, the effects of tea polyphenol on the structural and physicochemical properties of Chinese yam starch using autoclave-assisted pullulanase treatme...

  • Article
  • Open Access
4 Citations
3,567 Views
16 Pages

In Vivo Tissue Distribution and Pharmacokinetics of FITC-Labelled Hizikia fusiforme Polyphenol–Polysaccharide Complex in Mice

  • Yutong Li,
  • Shangkun Li,
  • Di Li,
  • Yuan Gao,
  • Shuhua Kong,
  • Jingyi Liu,
  • Shu Liu,
  • Yichao Ma,
  • Hui Zhou and
  • Yunhai He
  • + 2 authors

23 September 2024

In this study, a quantitative method based on fluorescein isothiocyanate (FITC)-labelled Hizikia fusiforme polyphenol–polysaccharide complex (HPC) and its purified fractions (PC1, PC4) was used, and its pharmacokinetics and tissue distribution...

  • Article
  • Open Access
6 Citations
2,469 Views
18 Pages

29 January 2024

This study aims to enhance gelatin film performance in the food industry by incorporating polyphenol–titanium complexes (PTCs) as crosslinkers. PTCs introduce multiple linkages with gelatin, including coordination and hydrogen bonds, resulting...

  • Review
  • Open Access
8 Citations
4,820 Views
14 Pages

30 March 2021

Cognitive function is a key aspect of healthy aging. Inflammation associated with normal aging, also called inflammaging is a primary risk factor for cognitive decline. A diet high in fruits and vegetable and lower in calories, particularly a Mediter...

  • Article
  • Open Access
2 Citations
2,014 Views
13 Pages

Health-Promoting Properties of Pectin–Polyphenol Complex Extracted from Olive Oil By-Product Alperujo: Antioxidant, Antiproliferative, and Anti-Inflammatory Activities

  • Alejandra Bermúdez-Oria,
  • María Luisa Castejón,
  • Fátima Rubio-Senent,
  • Guillermo Rodríguez-Gutiérrez and
  • Juan Fernández-Bolaños

30 August 2024

This research explores the health-promoting properties of the pectin–polyphenol complex extracted from alperujo, a by-product of olive oil production. This study investigates the chemical composition and antioxidant activity of the extracts, re...

  • Feature Paper
  • Article
  • Open Access
3 Citations
3,649 Views
11 Pages

16 September 2021

Adhesive hydrogels have been utilized as tissue sealants, hemostatic agents, and wound dressings, with the aim of replacing conventional sutures. To prevent immune response and serious inflammation from those hydrogels after sealing, natural biocompa...

  • Article
  • Open Access
9 Citations
4,106 Views
17 Pages

Complexes of Soluble Dietary Fiber and Polyphenols from Lotus Root Regulate High-Fat Diet-Induced Hyperlipidemia in Mice

  • Zhan Zheng,
  • Weilan Gao,
  • Zhenzhou Zhu,
  • Shuyi Li,
  • Xueling Chen,
  • Giancarlo Cravotto,
  • Yong Sui and
  • Lei Zhou

In this paper, complexes of soluble dietary fiber (SDF) and polyphenols (PPs) isolated from lotus roots were prepared (SDF-PPs), as well as physical mixtures (SDF&PPs), which were given to high-fat-diet (HFD)-fed mice. The results demonstrated th...

  • Communication
  • Open Access
57 Citations
7,001 Views
10 Pages

Presence of Polyphenols Complex Aromatic “Lignin” in Sargassum spp. from Mexican Caribbean

  • Liliana Alzate-Gaviria,
  • Jorge Domínguez-Maldonado,
  • Rubí Chablé-Villacís,
  • Edgar Olguin-Maciel,
  • Rosa María Leal-Bautista,
  • Gonzalo Canché-Escamilla,
  • Adán Caballero-Vázquez,
  • Cecilia Hernández-Zepeda,
  • Felipe Alonso Barredo-Pool and
  • Raúl Tapia-Tussell

In recent years, the massive influx of pelagic Sargassum spp. has generated great interest in the scientific community, highlighting the urgency of addressing the physiology and biochemical composition of these species. Until now, the presence of lig...

  • Article
  • Open Access
1 Citations
1,460 Views
18 Pages

Evaluation of the Efficiency of Encapsulation and Bioaccessibility of Polyphenol Microcapsules from Cocoa Pod Husks Using Different Techniques and Encapsulating Agents

  • Astrid Natalia González Morales,
  • Luis Javier López-Giraldo,
  • Erika Sogamoso González and
  • Yaiza Moscote Chinchilla

27 September 2025

Cocoa pod husk (CPH) has the potential to be utilized for polyphenol extraction to be used in functional food formulations and pharmaceutical formulations due to its health benefits. However, polyphenols are sensitive to environmental factors that re...

  • Article
  • Open Access
9 Citations
4,030 Views
11 Pages

23 November 2018

Honey is composed of macromolecules arranged into multicomponent colloidal particles dispersed in a supersaturated sugar solution. The core part of colloidal particles in honey is made up of high-molecular weight protein-polyphenol complexes. We desi...

  • Review
  • Open Access
36 Citations
7,123 Views
24 Pages

Structural, Binding and Functional Properties of Milk Protein-Polyphenol Systems: A Review

  • Tessa M. van de Langerijt,
  • James A. O’Mahony and
  • Shane V. Crowley

Polyphenols (PP) are linked to health benefits (e.g., prevention of cancer, cardiovascular disease and obesity), which are mainly attributed to their antioxidant activity. During digestion, PP are oxidised to a significant degree reducing their bio-f...

  • Article
  • Open Access
614 Views
25 Pages

Effective Antioxidants as Plausible Ligands in Chromium(III) Supplementation: How Complexation Modulates Catechol-Based Polyphenols

  • Hanna Lewandowska,
  • Zhe Chen,
  • Krystian Marszałek,
  • Włodzimierz Lewandowski and
  • Renata Świsłocka

19 November 2025

This study examines the impact of metal coordination on the antioxidant and pro-oxidant properties of 3,4-dihydroxybenzoic acid (3,4-DHBA) and caffeic acid (CA). Their Na(I), K(I) salts and Cr(III) complexes were evaluated in vitro using radical scav...

  • Article
  • Open Access
3 Citations
2,761 Views
29 Pages

Molecular Interplay Between Plant Proteins and Polyphenols: pH as a Switch for Structural and Functional Assembly

  • Havva Aktaş,
  • Arkadiusz Szpicer,
  • Barbara Strojny-Cieślak,
  • Wojciech Borucki,
  • Ute Schweiggert-Weisz and
  • Marcin A. Kurek

21 November 2025

Understanding how plant proteins interact with polyphenols under different pH conditions is key to unlocking the full functional potential of natural ingredients in food systems. This study investigates the pH-dependent binding mechanisms and structu...

  • Article
  • Open Access
3 Citations
2,464 Views
16 Pages

Antioxidant and Protective Effects of the Polyphenolic Glycoconjugate from Agrimonia eupatoria L. Herb in the Prevention of Inflammation in Human Cells

  • Marta Tsirigotis-Maniecka,
  • Ewa Zaczyńska,
  • Anna Czarny,
  • Piotr Jadczyk,
  • Barbara Umińska-Wasiluk,
  • Roman Gancarz and
  • Izabela Pawlaczyk-Graja

Herein, structural and biological studies of a complex biopolymer (polyphenolic glycoconjugate) isolated from the flowering parts of Agrimonia eupatoria L. (AE) are presented. Spectroscopic analyses (UV–Vis and 1H NMR) of the aglycone component...

  • Article
  • Open Access
4 Citations
3,401 Views
20 Pages

4 December 2023

Nowadays, medium chain triglycerides (MCT) with special health benefits have been increasingly applied for fortifying food products. Therefore, the present work aimed to investigate the effects of MCT on traditional tea polyphenols-fortified cooked r...

  • Article
  • Open Access
20 Citations
5,176 Views
15 Pages

26 March 2020

Previously, we have revealed that prolonged administration of a polyphenol-rich 0.1% extract from the berries of Aronia melanocarpa L. (chokeberries) alone and under chronic exposure to cadmium influences the body status of zinc (Zn) and copper (Cu)....

  • Review
  • Open Access
8 Citations
5,874 Views
8 Pages

Dental Application of Natural Products

  • Hiroshi Sakagami and
  • Mineko Tomomura

14 February 2018

This review article summarizes the recent progress in dental applications of natural products. Catechin gel showed selective antimicrobial activity, whereas the alkaline extract of various plant species rich in lignin carbohydrate complex (LCC) showe...

  • Review
  • Open Access
124 Citations
18,852 Views
35 Pages

Prebiotics from Seaweeds: An Ocean of Opportunity?

  • Paul Cherry,
  • Supriya Yadav,
  • Conall R. Strain,
  • Philip J. Allsopp,
  • Emeir M. McSorley,
  • R. Paul Ross and
  • Catherine Stanton

1 June 2019

Seaweeds are an underexploited and potentially sustainable crop which offer a rich source of bioactive compounds, including novel complex polysaccharides, polyphenols, fatty acids, and carotenoids. The purported efficacies of these phytochemicals hav...

  • Review
  • Open Access
100 Citations
9,818 Views
24 Pages

Molecular Mechanisms and Applications of Polyphenol-Protein Complexes with Antioxidant Properties: A Review

  • Yulin Feng,
  • Chengming Jin,
  • Shihao Lv,
  • Huijuan Zhang,
  • Feiyue Ren and
  • Jing Wang

8 August 2023

Proteins have been extensively studied for their outstanding functional properties, while polyphenols have been shown to possess biological activities such as antioxidant properties. There is increasing clarity about the enhanced functional propertie...

  • Communication
  • Open Access
4 Citations
3,109 Views
9 Pages

Short-Term Effect of Nutraceutical Fruit Juices on Lipid Metabolism in Patients with Acquired Hypercholesterolemia

  • Diego Ardissino,
  • Alessandro Colletti,
  • Marzia Pellizzato,
  • Gianna Pagliari,
  • Francesco Di Pierro and
  • Giancarlo Cravotto

The crucial role of dyslipidaemia, especially hypercholesterolemia, in the development of atherosclerosis-related cardiovascular diseases has been extensively documented in genetic, pathologic, observational and intervention studies. The European gui...

  • Article
  • Open Access
28 Citations
4,639 Views
13 Pages

Polyphenols and Antioxidant Activity of Citrus Fiber/Blackberry Juice Complexes

  • Ivana Buljeta,
  • Anita Pichler,
  • Josip Šimunović and
  • Mirela Kopjar

21 July 2021

The objective of this study was to investigate the use of citrus fiber as a carrier of blackberry juice polyphenols. For that purpose, freeze-dried complexes with blackberry juice and different amounts of citrus fiber (1%, 2% and 4%) were prepared. C...

  • Review
  • Open Access
10 Citations
3,710 Views
18 Pages

11 July 2024

Allergies towards gluten and legumes (such as, soybean, peanut, and faba bean) are a global issue and, occasionally, can be fatal. At the same time, an increasing number of households are shifting to plant protein ingredients from these sources, whic...

  • Article
  • Open Access
112 Citations
5,052 Views
23 Pages

From Green Remediation to Polymer Hybrid Fabrication with Improved Optical Band Gaps

  • M. A. Brza,
  • Shujahadeen B. Aziz,
  • H. Anuar and
  • Muataz Hazza F. Al Hazza

11 August 2019

The present work proposed a novel approach for transferring high-risk heavy metals tometal complexes via green chemistry remediation. The method of remediation of heavy metals developed in the present work is a great challenge for global environmenta...

  • Article
  • Open Access
8 Citations
2,996 Views
18 Pages

Microwave-Induced Behavior and Digestive Properties of the Lotus Seed Starch—Chlorogenic Acid Complex

  • Xiangfu Jiang,
  • Jianyi Wang,
  • Lanxin Li,
  • Baodong Zheng,
  • Shuyi Zheng and
  • Xu Lu

28 June 2023

The effect of chlorogenic acid (CA) on the dielectric response of lotus seed starch (LS) after microwave treatment, the behavior and digestive characteristics of the resulting starch/chlorogenic acid complex (LS-CA) at different degrees of gelatiniza...

  • Article
  • Open Access
1,022 Views
18 Pages

22 August 2025

Rice bran protein (RBP) is an important plant protein, but its functional properties are reduced due to the presence of disulfide bonds in the structure. Polyphenol modification is an effective strategy to improve protein functional properties. Howev...

  • Article
  • Open Access
14 Citations
3,381 Views
13 Pages

Identifying Major Drivers of Antioxidant Activities in Complex Polyphenol Mixtures from Grape Canes

  • Manon Ferrier,
  • Kévin Billet,
  • Samantha Drouet,
  • Duangjai Tungmunnithum,
  • Magdalena Anna Malinowska,
  • Cécile Marchal,
  • Sandrine Dedet,
  • Nathalie Giglioli-Guivarc’h,
  • Christophe Hano and
  • Arnaud Lanoue

23 June 2022

Grape canes represent a valuable source of numerous polyphenols with antioxidant properties, whose compositions vary depending on the genotype and environmental factors. Antioxidant activities of pure molecules are often reported without considering...

  • Review
  • Open Access
21 Citations
7,660 Views
29 Pages

Recent Progress of Basic Studies of Natural Products and Their Dental Application

  • Hiroshi Sakagami,
  • Taihei Watanabe,
  • Tomonori Hoshino,
  • Naoto Suda,
  • Kazumasa Mori,
  • Toshikazu Yasui,
  • Naoki Yamauchi,
  • Harutsugu Kashiwagi,
  • Tsuneaki Gomi and
  • Yoshiaki Sugita
  • + 4 authors

25 December 2018

The present article reviews the research progress of three major polyphenols (tannins, flavonoids and lignin carbohydrate complexes), chromone (backbone structure of flavonoids) and herbal extracts. Chemical modified chromone derivatives showed highl...

  • Review
  • Open Access
38 Citations
5,826 Views
23 Pages

16 May 2024

Understanding the nuanced interplay between plant polyphenols and starch could have significant implications. For example, it could lead to the development of tailor-made starches for specific applications, from bakinag and brewing to pharmaceuticals...

  • Article
  • Open Access
10 Citations
3,677 Views
10 Pages

24 February 2022

The roots of Melastoma malabathricum subsp. normale (D. Don) Karst. Mey have been used in traditional ethnic medicine systems in China to treat inflammation-triggered ailments, such as trauma, toothache, and fever. Therefore, the aim of this study is...

  • Article
  • Open Access
1,230 Views
12 Pages

30 November 2024

Polyphenolic compounds are considered one as the most important plant-originated species with antioxidant properties. This paper focuses on exploring the structure and antiradical properties of supramolecular complexes derived from the selected polyp...

  • Article
  • Open Access
10 Citations
3,594 Views
21 Pages

Hydroxytyrosol Counteracts Triple Negative Breast Cancer Cell Dissemination via Its Copper Complexing Properties

  • Nunzio Perta,
  • Laura Torrieri Di Tullio,
  • Elisa Cugini,
  • Paola Fattibene,
  • Maria Cristina Rapanotti,
  • Ilaria Borromeo,
  • Cinzia Forni,
  • Patrizia Malaspina,
  • Tiziana Cacciamani and
  • Anastasia De Luca
  • + 2 authors

16 November 2023

Polyphenols have gained increasing attention for their therapeutic potential, particularly in conditions like cancer, due to their established antioxidant and anti-inflammatory properties. Recent research highlights their ability to bind to transitio...

  • Article
  • Open Access
17 Citations
4,389 Views
24 Pages

14 June 2022

Polyphenols are inversely associated with the incidence of chronic diseases, but therapeutic use is limited by poor stability and bioaccessibility. Encapsulation has been shown to overcome some of these limitations. A selection of polyphenols (catech...

  • Article
  • Open Access
20 Citations
3,196 Views
19 Pages

23 May 2023

During the storage and processing of mung beans, proteins and polyphenols are highly susceptible to interactions with each other. Using globulin extracted from mung beans as the raw material, the study combined it with ferulic acid (FA; phenolic acid...

  • Article
  • Open Access
16 Citations
4,504 Views
22 Pages

21 August 2023

Previous studies have shown that interaction between polyphenols and proteins can benefit health, but the mechanism of its antidiabetic effect has not been thoroughly elucidated. Therefore, this study aimed to investigate the impact of the metallothi...

  • Article
  • Open Access
1 Citations
2,041 Views
18 Pages

10 January 2025

To investigate the impact of tea polyphenols on the thermodynamic properties, gelatinization properties, rheological properties, and digestion characteristics of starch after ball milling, canna starch and tea polyphenols were mixed at a 10:1 ratio (...

  • Article
  • Open Access
2 Citations
2,422 Views
17 Pages

23 August 2024

Addressing the challenge of blood glucose fluctuations triggered by the ingestion of pea starch, we have adopted an eco-friendly strategy utilizing microwave irradiation to synthesize the novel pea starch–tea polyphenol complexes. These complex...

  • Article
  • Open Access
27 Citations
4,805 Views
20 Pages

8 April 2020

Seven extraction methods, including hot water extraction (HWE), pressurized water extraction (PWE), ultrasound-assisted extraction, microwave-assisted extraction, ultrasound-assisted enzymatic extraction, high-speed shearing homogenization extraction...

  • Article
  • Open Access
3 Citations
4,391 Views
13 Pages

Multicolor Hair Dyeing with Biocompatible Dark Polyphenol Complex-Integrated Shampoo with Reactive Oxygen Species Scavenging Activity

  • Tae Min Kim,
  • Hyun Jeong Won,
  • Jun-Ho Yang,
  • Hayeon Jo,
  • A Hyeon Kim,
  • Dohyun Nam,
  • Seul Gi Kim,
  • Eun-Jung Jin,
  • Heung Jin Bae and
  • Sung Young Park

Hair dyeing has become a prevalent lifestyle trend, especially within the fashion industry. However, it possesses disadvantages, such as containing carcinogenic and toxic materials. In this study, we developed a biocompatible hair-dyeing technology u...

  • Review
  • Open Access
542 Views
23 Pages

Polyphenols, Polysaccharides, and Their Complexes from Aronia melanocarpa in the Chemoprevention of Colorectal Cancer

  • Karolina Niewinna,
  • Katarzyna Owczarek,
  • Zuzanna Senkowska and
  • Urszula Lewandowska

19 December 2025

Colorectal cancer (CRC) is among the three most commonly diagnosed malignancies worldwide and remains a major public health challenge, emphasizing the need for effective preventive strategies. Considering the current chemotherapy limitations of key a...

  • Article
  • Open Access
8 Citations
3,343 Views
13 Pages

29 September 2021

The present study aimed to explore the impacts of in vitro simulated saliva-gastrointestinal digestion on physicochemical and biological properties of the polyphenolic-protein-polysaccharide ternary complex (PPP) extracted from Hovenia dulcis. The re...

  • Article
  • Open Access
31 Citations
8,328 Views
17 Pages

Synergistic Effect of Polyphenol-Rich Complex of Plant and Green Propolis Extracts with Antibiotics against Respiratory Infections Causing Bacteria

  • Anna Ramata-Stunda,
  • Zaiga Petriņa,
  • Valda Valkovska,
  • Mārtiņs Borodušķis,
  • Līga Gibnere,
  • Eleonora Gurkovska and
  • Vizma Nikolajeva

Bacterial infections are a prevalent complication after primary viral respiratory infections and are associated with high morbidity and mortality. Antibiotics are widely used against bacterial respiratory pathogens; however, the rise in antibiotic-re...

  • Article
  • Open Access
17 Citations
3,046 Views
12 Pages

Effect of the Olive Oil Extraction Process on the Formation of Complex Pectin–Polyphenols and Their Antioxidant and Antiproliferative Activities

  • Alejandra Bermúdez-Oria,
  • Elisa Rodríguez-Juan,
  • Guillermo Rodríguez-Gutiérrez,
  • África Fernández-Prior and
  • Juan Fernández-Bolaños

23 November 2021

The aim of this research was to investigate the interaction of phenols and pectic polysaccharides during the olive oil extraction process. For this, pectin was extracted from fresh olive fruits and compared to the pectin isolated from the paste resul...

  • Article
  • Open Access
9 Citations
3,067 Views
15 Pages

1 September 2020

Antioxidant packaging is an effective method to protect oxygen-sensitive food from oxidation. In order to concurrently obtain a storage stability and excellent oxygen scavenging of antioxidant film for the high moisture food, a moisture activating ox...

  • Article
  • Open Access
10 Citations
8,060 Views
14 Pages

In this study, we developed a hair-coating polyphenol complex (PPC) that showed ultraviolet (UV) protection properties, antistatic features, and the capability to enhance the mechanical strength of damaged hair. PPCs prepared with different ratios of...

  • Article
  • Open Access
826 Views
12 Pages

Pharmacological Effect of Water-Extractable (Poly)Phenolic Polysaccharide–Protein Complexes from Prunus spinosa L. Wild Fruits

  • Šutovská Martina,
  • Miroslava Molitorisová,
  • Jozef Mažerik,
  • Iveta Uhliariková and
  • Peter Capek

Wild fruits are distributed worldwide, but are consumed mainly in developing countries, where they are an important part of the diet. Still, in many other countries, they are consumed only locally. Blackthorn (Prunus spinosa L.) is an underutilized s...

  • Article
  • Open Access
1,125 Views
16 Pages

4 May 2025

Triboelectric nanogenerators (TENGs) are ideal for meeting the global demand for sustainable energy in energy harvesting and wearable electronics. While biomaterials like polysaccharides are well studied in TENGs, the potential of polyphenols and the...

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