Next Article in Journal
Nutrient Deprivation-Associated Changes in Green Microalga Coelastrum sp. TISTR 9501RE Enhanced Potent Antioxidant Carotenoids
Next Article in Special Issue
Padina pavonica Extract Promotes In Vitro Differentiation and Functionality of Human Primary Osteoblasts
Previous Article in Journal
Sea Anemone Toxins: A Structural Overview
Previous Article in Special Issue
Integral Utilization of Red Seaweed for Bioactive Production
Open AccessReview

Prebiotics from Seaweeds: An Ocean of Opportunity?

1
Nutrition Innovation Centre for Food and Health, Ulster University, Cromore Road, Coleraine, Co. Londonderry BT52 1SA, UK
2
Teagasc Food Research Centre, Moorepark, Fermoy, P61 C996 Co. Cork, Ireland
3
APC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland
4
College of Science, Engineering and Food Science, University College Cork, T12 K8AF Cork, Ireland
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(6), 327; https://doi.org/10.3390/md17060327
Received: 1 May 2019 / Revised: 27 May 2019 / Accepted: 29 May 2019 / Published: 1 June 2019
Seaweeds are an underexploited and potentially sustainable crop which offer a rich source of bioactive compounds, including novel complex polysaccharides, polyphenols, fatty acids, and carotenoids. The purported efficacies of these phytochemicals have led to potential functional food and nutraceutical applications which aim to protect against cardiometabolic and inflammatory risk factors associated with non-communicable diseases, such as obesity, type 2 diabetes, metabolic syndrome, cardiovascular disease, inflammatory bowel disease, and some cancers. Concurrent understanding that perturbations of gut microbial composition and metabolic function manifest throughout health and disease has led to dietary strategies, such as prebiotics, which exploit the diet-host-microbe paradigm to modulate the gut microbiota, such that host health is maintained or improved. The prebiotic definition was recently updated to “a substrate that is selectively utilised by host microorganisms conferring a health benefit”, which, given that previous discussion regarding seaweed prebiotics has focused upon saccharolytic fermentation, an opportunity is presented to explore how non-complex polysaccharide components from seaweeds may be metabolised by host microbial populations to benefit host health. Thus, this review provides an innovative approach to consider how the gut microbiota may utilise seaweed phytochemicals, such as polyphenols, polyunsaturated fatty acids, and carotenoids, and provides an updated discussion regarding the catabolism of seaweed-derived complex polysaccharides with potential prebiotic activity. Additional in vitro screening studies and in vivo animal studies are needed to identify potential prebiotics from seaweeds, alongside untargeted metabolomics to decipher microbial-derived metabolites from seaweeds. Furthermore, controlled human intervention studies with health-related end points to elucidate prebiotic efficacy are required. View Full-Text
Keywords: seaweed; gut microbiota; prebiotics; dietary fibre; complex polysaccharides; polyphenols; polyunsaturated fatty acids; carotenoids; phytochemicals seaweed; gut microbiota; prebiotics; dietary fibre; complex polysaccharides; polyphenols; polyunsaturated fatty acids; carotenoids; phytochemicals
MDPI and ACS Style

Cherry, P.; Yadav, S.; Strain, C.R.; Allsopp, P.J.; McSorley, E.M.; Ross, R.P.; Stanton, C. Prebiotics from Seaweeds: An Ocean of Opportunity? Mar. Drugs 2019, 17, 327.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop