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Recent Progress of Basic Studies of Natural Products and Their Dental Application

1
Meikai University Research Institute of Odontology (M-RIO), 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan
2
Division of Pediatric Dentistry, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan
3
Division of Orthodontics, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan
4
Division of First Oral and Maxillofacial Surgery, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan
5
Division of Oral Health, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan
6
Masuko Memorial Hospital, 35-28 Takehashi-cho, Nakamura-ku, Nagoya 453-8566, Japan
7
Ecopale Co., Ltd., 885 Minamiisshiki, Nagaizumi-cho, Suntou-gun, Shizuoka 411-0932, Japan
8
Gomi clinic, 1-10-12 Hyakunin-cho, Shinjuku-ku, Tokyo 169-0073, Japan
9
Daiwa Biological Research Institute Co., Ltd., 3-2-1 Sakado, Takatsu-ku, Kawasaki, Kanagawa 213-0012, Japan
10
Department of Medical Molecular Informatics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan, [email protected] (J.N.)
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Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Sakado, Saitama 350-0295, Japan
*
Author to whom correspondence should be addressed.
Medicines 2019, 6(1), 4; https://doi.org/10.3390/medicines6010004
Received: 14 November 2018 / Revised: 10 December 2018 / Accepted: 19 December 2018 / Published: 25 December 2018
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Abstract

The present article reviews the research progress of three major polyphenols (tannins, flavonoids and lignin carbohydrate complexes), chromone (backbone structure of flavonoids) and herbal extracts. Chemical modified chromone derivatives showed highly specific toxicity against human oral squamous cell carcinoma cell lines, with much lower toxicity against human oral keratinocytes, as compared with various anticancer drugs. QSAR analysis suggests the possible correlation between their tumor-specificity and three-dimensional molecular shape. Condensed tannins in the tea extracts inactivated the glucosyltransferase enzymes, involved in the biofilm formation. Lignin-carbohydrate complexes (prepared by alkaline extraction and acid-precipitation) and crude alkaline extract of the leaves of Sasa species (SE, available as an over-the-counter drug) showed much higher anti-HIV activity, than tannins, flavonoids and Japanese traditional medicine (Kampo). Long-term treatment with SE and several Kampo medicines showed an anti-inflammatory and anti-oxidant effects in small size of clinical trials. Although the anti-periodontitis activity of synthetic angiotensin II blockers has been suggested in many papers, natural angiotensin II blockers has not yet been tested for their possible anti-periodontitis activity. There should be still many unknown substances that are useful for treating the oral diseases in the natural kingdom. View Full-Text
Keywords: polyphenol; chromone; lignin-carbohydrate complex; alkaline extract; Kampo medicine; glucosyltransferase; angiotensin II blocker; QSAR analysis; oral diseases; dental application polyphenol; chromone; lignin-carbohydrate complex; alkaline extract; Kampo medicine; glucosyltransferase; angiotensin II blocker; QSAR analysis; oral diseases; dental application
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Sakagami, H.; Watanabe, T.; Hoshino, T.; Suda, N.; Mori, K.; Yasui, T.; Yamauchi, N.; Kashiwagi, H.; Gomi, T.; Oizumi, T.; Nagai, J.; Uesawa, Y.; Takao, K.; Sugita, Y. Recent Progress of Basic Studies of Natural Products and Their Dental Application. Medicines 2019, 6, 4.

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