Intact stability represents one of the most important topics when addressing ship safety, and it is ruled by the IMO Intact Stability code, evaluating ship stability in a calm water scenario. However, the interest in ship stability in waves has incre...
This paper provides a discussion of the technical and theoretical ambiguities, requirements, and limitations to develop a practical implementation of the IMO Second Generation Intact Stability criteria. This discussion is the result of industry colla...
To face the design of a new ship concept, the evaluation of multiple feasible solutions concerning several aspects of naval architecture and marine engineering is necessary. Compressed natural gas technologies are in continuous development; therefore...
A methodology is presented to systematically modify the hull shape of a ballast-free container ship, in order to manage the issue of righting lever variation in waves. The IMO second generation intact stability criteria have been identified as a stab...
At the beginning of 2020, after a long and demanding process, the Second Generation Intact Stability criteria (SGISc) have been finalized at the 7th session of the International Maritime Organization (IMO) sub-committee on Ship Design and Constructio...
Recently, the IMO (International Maritime Organization) has reviewed technical issues considering the second generation intact stability criteria in the design stage of ships. In this paper, the evaluation procedure for Lv1 (Level 1) and Lv2 (Level 2...
An evaluation was conducted to assess the surf-riding/broaching vulnerability of a 9.77-ton fishing boat by applying the regulations for stability assessment proposed by IMO (International Maritime Organization). Both Level 1 and 2 assessments were c...
In late years, the size of RoRo cargo ships has continuously increased, leading to the so-called Large Car Truck Carriers (LCTC). The design of these vessels introduced new challenges that shall be considered during the ship design since the conceptu...
In this paper, the evaluation procedure for Level 1, Level 2A, and Level 2B for the parametric roll among the five modes of the IMO second generation stability criteria was explained in detail. Parametric roll mode evaluation was performed using the...
To evaluate the safety of passenger ships’ stability, ten stability parameters should be calculated. However, since the process for calculating all stability parameters is complex without a ship loading program, a convenient methodology to simp...
Securing a ship’s safe stability is essential. Thus, monitoring the stability parameters of the IMO requirements is required to provide an alert about the risk of the safety of ships’ stability to the captain, officers, and the crew of a ship. Howeve...
The first technical factor involved in maritime accidents is related to the lack of intact stability. The current stability criterion, based on fixing a minimum value for each of the different static and dynamic righting arms, is not regarded as sati...
The second-generation intact stability criteria, including five stability failure modes, were approved by the International Maritime Organization (IMO) in 2020, and it is an urgent task to develop the numerical method for the significant roll motion...
In this paper, the application of the excessive acceleration (EA) criterion, one of five intact stability failure modes, within the second generation intact stability criteria (SGISC) framework, is shown for a set of naval vessels. First and second l...
The interim guidelines of second-generation intact stability criteria and their explanatory note were issued by the IMO in 2022. However, due to their complexity, the direct stability assessments of broaching and loss of stability still need to be ma...
The IMO’s second-generation intact stability criteria (SGISc) have been applied to a set of seven megayacht units ranging from 40 m to 80 m. The application aims to evaluate their stability performance in a seaway. The assessment is based on tw...
The International Maritime Organization (IMO) finalized the second-generation intact stability criteria in 2022. However, an accurate and practical numerical method for stability loss has yet to be established. Therefore, a 6 DOF numerical model is f...
The operational measure (OM) of the Second-Generation Intact Stability Criteria (SGISC) is the initial step toward the design of a performance-based dynamic stability assessment of the ship by considering the vessel’s operation, loading conditi...
Humanin is the first identified mitochondrial-derived peptide. Humanin-G (HNG) is a variant of Humanin that has significantly higher cytoprotective properties. Here, we describe the stability features of HNG in different conditions and characterize H...
Rainfall-induced failures in red clay slopes are common, yet the coupled influence of soil structure degradation and rainfall temporal patterns on slope hydromechanical behavior remains poorly understood. This study advances the understanding by inve...
Folding of the Protein G B1 domain (PGB1) shifts with increasing salt concentration from a cooperative assembly of inherently unstructured subdomains to an assembly of partly pre-folded structures. The salt-dependence of pre-folding contributes to th...
Coalbed methane is a double-edged sword with two attributes of energy and hazard in coal mines. Gas drainage is the most direct and effective measure for gas recovery and disaster prevention in coal mines, which is seriously affected by the mechanics...
Cervical laminoplasty is a useful for treatment for cervical myelopathy. However, this procedure has limitations for kyphotic cervical alignments. We used the finite element (FE) analysis and investigated the biomechanical changes in intact and lamin...
The main sponge cake ingredients are flour, sucrose, eggs and leavening agents. Exogenous lipids (e.g., monoacylglycerols) are often used to increase air–liquid interface stability in the batter. There is a consumer trend to avoid foods contain...
The structures and applications of metal-organic framework materials (MOFs) have been attracting great interest due to the wide variety of possible applications, for example, chemical sensing, separation, and catalysis. N-[3-(Trimethoxysilyl)propyl]e...
This work aimed to examine the effects of sex on meat and fat quality traits from thirty Portuguese Alentejano (AL) pigs reared in outdoor conditions. These pigs were divided into three groups and fed ad libitum. From ~40 to 130 kg LW, castrated (C g...
A robust method was developed to investigate the liposomal behavior of novel enzymatically-synthesized hydroxytyrosol and tyrosol phospholipids. Bilayer characteristic obtained by this method, including bilayer formation stability and adsorption prop...
Background and Objectives: The anterolateral ligament (ALL) could be the potential anatomical structure responsible for rotational instability after anterior cruciate ligament (ACL) reconstruction. The purpose of this study was to investigate the ana...
We investigated the effects of resveratrol (RES) on the oxidative stability of emulsions composed of stripped corn oil, acidic water and Tween 20 and determined its distribution in the intact emulsions by employing a well-established kinetic method....
The water sensitivity and structural characteristics of collapsible loess are two typical factors that significantly influence its mechanical behaviors. This paper presents a simple and practical elastic-plastic model based on the modified Cam-Clay m...
The purpose of this study was to investigate whether a watch-shaped external wrist band brace improves distal radioulnar joint (DRUJ) stability. Seven fresh cadaveric arms were used. Using a customized testing system, volar and dorsal translation for...
Lumbar disc herniation (LDH) is a common condition which can lead to back pain. Although surgical treatments for LDH are well established, complications such as spinal instability and narrowing of adjacent facet joints are still frequently reported....
Radiolabeled gastrin-releasing peptide receptor (GRPR) antagonists have shown great promise for the theranostics of prostate cancer; however, their suboptimal metabolic stability leaves room for improvements. It was recently shown that the replacemen...
The administration of isolated mitochondria is a promising strategy for protecting cells from oxidative damage. This study aimed to identify mitochondrial characteristics that contribute to stronger protective effects. We compared two types of mitoch...
There are many techniques for the treatment of chronic scapholunate dissociation. The three-ligament tenodesis (3LT) is used most widely, but reconstruction of the dorsal ligament alone may not provide sufficient stability. The Mark–Henry techn...
Foot-and-mouth disease (FMD) vaccine efficacy is mainly determined by the content of intact virions (146S) and empty capsids (75S). Both particles may dissociate into 12S subunits upon vaccine manufacturing, formulation, and storage, reducing vaccine...
To enhance the functional properties of walnut protein isolate (WalPI), hydrophilic whey protein isolate (WPI) was selected to formulate WalPI-WPI nanoparticles (nano-WalPI-WPI) via a pH cycling technique. These nano-WalPI-WPI particles were subseque...
Cervical laminoplasty is a valuable procedure for myelopathy but it is associated with complications such as increased kyphosis. The effect of ligament damage during cervical laminoplasty on biomechanics is not well understood. We developed the C2–C7...
Targeting of cholecystokinin-2 receptor (CCK2R) expressing tumors using radiolabeled minigastrin (MG) analogs is hampered by rapid digestion of the linear peptide in vivo. In this study, a new MG analog stabilized against enzymatic degradation was in...
(1) The studies on the influence of rainfall on slope stability mainly focus on rainfall characteristics and the variation of strength parameters. Few studies pay attention to the micro structure changes of rock mass under long-term rainfall conditio...
The long-term storage stability of vaccines has a major impact on the roll-out and success of global immunization programs. For the Human Immunodeficiency Virus type 1 (HIV-1) virus-like particle (VLP) vaccine prototype evaluated here, nanoparticle t...
Integrating dissolving microneedles (DMNs) and nanocarriers (NC) holds great potential in transdermal drug delivery because it can simultaneously overcome the stratum corneum barrier and achieve efficient and controlled drug delivery. However, differ...
Recent studies have shown that soybean protein and its peptides have cholesterol-lowering activities. However, it is not clear whether these peptides could overcome physiological barriers, such as phase II metabolism in gastrointestinal tract and poo...
We used large area, monolayer graphene epitaxially grown on SiC (0001) as contact electrodes for polymer nanofiber devices. Our fabrication process, which avoids polymer resist residues on the graphene surface, results in graphene-polyaniline nanofib...
Background/Objectives: EPICERTIN, a biotherapeutic candidate for mucosal healing in inflammatory bowel disease (IBD) and other mucosal disorders, was subjected to an extensive long-term stability program to evaluate its molecular stability and physic...
In recent years, nuclear medicine has gained great interest, partly due to the success story of [177Lu]Lu-PSMA-617 (PluvictoTM). Still, in-depth preclinical characterization of radiopharmaceuticals mainly happens at centers that allow working with ra...
The complexity of therapeutic proteins like antibody–drug conjugates (ADCs) holds a tremendous analytical challenge. Complementary mass spectrometry approaches such as peptide mapping and intact mass analysis are required for the in-depth chara...
Exploring the relationship between the magnitude and temporal trend of the Biodiversity Intactness Index (BII) is critical to assessing current and future changes in biodiversity intactness. However, investigations into the relationship between BII m...
The stability of high rock slopes is largely controlled by the location and orientation of geological features, such as faults, folds, joints, and bedding planes, which can induce structurally controlled slope instability. Under certain conditions, s...
Nanocrystals (NCs) have the potential to enhance the oral bioavailability of Class IV drugs in the Biopharmaceutical Classification System (BCS) due to the absorption of the intact crystals. The performance is compromised by the dissolution of NCs. D...
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