In this study, we developed a control strategy for a drug product prepared by high-shear wet granulation and roller compaction using integrated quality by design (QbD). During the first and second stages, we optimized the process parameters through t...
Control strategy and quality by design (QbD) are widely used to develop pharmaceutical products and improve drug quality; however, studies on fixed-dose combination (FDC) bilayer tablets are limited. In this study, the bilayer tablet consisted of hig...
Building information modeling (BIM) technology has been utilized increasingly in quantitative ways in the architecture, engineering, and construction disciplines. However, owing to increasing requirements for improvement in qualitative factors in BIM...
Oral solid drug delivery continues to be the gold standard in pharmaceutical formulations, owing to its cost-effectiveness, ease of administration, and high patient compliance. Tablets, the most widely used dosage form, are favored for their precise...
The article describes the results of the project “open source smart lamp” aimed at designing and developing a smart object able to manage and control the indoor environmental quality (IEQ) of the built environment. A first version of this smart objec...
The article describes the results of the project “open source Smart lamp” aimed at designing and developing a smart object able to manage and control the Indoor Environmental Quality (IEQ) of the built environment. A first version of this smart objec...
Facing rising building demands due to a fast-growing world population and significant environmental challenges at the same time, the building sector urgently requires innovation. The Cluster of Excellence Integrative Computational Design and Construc...
Capillary electrophoresis (CE) is a potent method for analyzing chiral substances and is commonly used in the enantioseparation and chiral purity control of pharmaceuticals from different matrices. The adoption of Quality by Design (QbD) concepts in...
Vaccine supply has a bottleneck in manufacturing capacity due to operation personnel and chemicals needed. Assessment of existing mRNA (messenger ribonucleic acid) vaccine processing show needs for continuous manufacturing processes. This is enabled...
Wet media milling is a fully industrialized technology for the manufacturing of drug nanocrystal suspensions. This work describes the development of an advanced control strategy and an associated design space for a manufacturing process at a commerci...
Built environment and infrastructure designs are produced in complex information systems. Managing this complexity poses a significant challenge; data scarcity and bias are substantial obstacles. This paper addresses the gap in data availability by m...
The rapid development of information and communication technology has fostered a natural integration of technology and design. As a result, there is increasing interest in Augmented Reality (AR) business card systems that leverage digital media. This...
Albumin nanocarrier research and development is a challenging area in the field of personalized medicine and in providing advanced therapeutic solutions. Albumin as a biocompatible, nonimmunogenic, and non-toxic protein carrier that can be exploited...
For aircraft employing the fly-by-wire technique, the closed-loop dynamic characteristics are determined by both the configuration design and the flight control system. As the capacity of the control system has certain limitations, the configuration...
Kecombrang flowers have bioactive components that can be used as food additives. The development of the kecombrang functional food industry for the production of food additives requires information on production parameters. The extraction process for...
A robust manufacturing process and the relationship between intermediate quality attributes (IQAs), critical quality attributes (CQAs), and critical process parameters (CPPs) for high-shear wet granulation was determined in this study. Based on quali...
A rapid and reproducible hydrophilic liquid chromatography (HILIC) process was established for concomitant determination of remogliflozin etabonate (RE), vildagliptin (VD), and metformin (MF) in a formulation. A face-centered central composite experi...
Design and control of smart rollators have attracted increasing research interests in the past decades. To meet the requirements of the elderly or disabled users, this paper proposes a novel design and tracking control scheme for empowering and assis...
Background/Objectives: Traditional Quality by Testing (QbT) strategies rely heavily on end-product testing and offer limited insight into how critical process parameters (CPPs) influence product quality. This increases the risk of variability and inc...
Various frameworks and methods, such as quality by design (QbD), real time release test (RTRT), and continuous process verification (CPV), have been introduced to improve drug product quality in the pharmaceutical industry. The methods recognize that...
Lyophilization is a widely used preservation method for thermosensitive products. It consists of three process steps: freezing, primary and secondary drying. One of the major drawbacks is the long processing time. The main optimization effort was put...
This research aims to develop an intelligent framework for quality control and fault detection in pre-production and post-production systems in Industry 4.0. In the pre-production system, the health of the manufacturing machine is monitored. In this...
6 March 2021
Background: An infectious disease can affect human beings at an alarming speed in modern society, where Coronavirus Disease 2019 (COVID-19) has led to a worldwide pandemic, posing grave threats to public security and the social economies. However, as...
CVCF (constant voltage, constant frequency) inverters are electronic devices used to supply AC loads from DC storage elements such as batteries or photovoltaic cells. These devices are used to feed different kinds of loads; this uncertainty requires...
Climate change affects fruit crops’ growth and development by delaying fruit ripening, reducing color development, and lowering fruit quality and yield. The irregular date palm fruit ripening in the past few years is assumed to be related to cl...
As the aging population increases, elderly drivers face challenges due to physical and cognitive decline, in addition to the growing complexity of in-car technology and interaction features. This study aims to optimize the in-car control interface fo...
This review aims to present the Quality by Design (QbD) model as a suitable methodology to perform research in the academic Costa Rican institutions that teach Pharmacy. Pubmed, Science Direct, and Google Scholar databases were screened for original...
A microgrid is a group of interconnected loads and distributed energy resources that can fill the gap between the dependence on a bulk power grid and the transition to renewable energies. The islanded mode presents itself as the most interesting scen...
Lyophilization is a widely used drying operation, but long processing times are a major drawback. Most lyophilization processes are conducted by a recipe that is not changed or optimized after implementation. With the regulatory demanded quality by d...
Digital twins have emerged as a powerful concept for real-time monitoring and analysis, facilitating Quality by Design integration into biopharmaceutical manufacturing. Traditionally, lyophilization processes are developed through trial-and-error, in...
Quality by design (QbD) serves as a systematic approach to pharmaceutical development, beginning with predefined objectives and emphasizing an understanding of the product based on sound science and risk management. The purpose of this study is to ut...
Recently, citizen involvement has been increasingly used in urban disaster prevention and management, taking advantage of new ubiquitous and collaborative technologies. This scenario has created a unique opportunity to leverage the work of crowds of...
Quality-by-Design (QbD) is demanded by regulatory authorities in biopharmaceutical production. Within the QbD frame advanced process control (APC), facilitated through process analytical technology (PAT) and digital twins (DT), plays an increasingly...
Traditional otic drug delivery methods lack controlled release capabilities, making reverse gelatination gels a promising alternative. Reverse gelatination gels are colloidal systems that transition from a sol to a gel phase at the target site, provi...
High-fidelity characterization and effective monitoring of spatial and spatiotemporal processes are crucial for high-performance quality control of many manufacturing processes and systems in the era of smart manufacturing. Although the recent develo...
Informative data collection is important in the identification and conservation of rare plant species. Data sets generated by many small-scale studies may be integrated into large, distributed databases, and statistical tools are being developed to e...
mRNA-based therapeutics are predicted to have a bright future. Recently, a B2C study was published highlighting the critical bottlenecks of mRNA manufacturing. The study focused on supply bottlenecks of various chemicals as well as shortages of skill...
During the construction of a diversion tunnel, geological problems often include faults, fragile strata, hard rock formations, karst landforms, etc., which may have adverse effects on the excavation and construction of the diversion tunnel. Based on...
In recent years, modular multilevel converters (MMC) are becoming popular in the distribution and transmission of electrical systems. The multilevel converter suffers from circulating current within the converter that increases the conduction loss of...
The development and adoption of digital twins (DT) for Quality-by-Design (QbD)-based processes with flexible operating points within a proven acceptable range (PAR) and automation through Advanced Process Control (APC) with Process Analytical Technol...
This study focuses on the design of a measuring system for monitoring the power quality within the SMART street lighting test polygon at university campuses with relation to testing an adaptive current control strategy for three-phase shunt active po...
Photovoltaic (PV) systems are at the heart of the energy transition, providing an essential source of clean, renewable energy for applications such as solar pumping, which is essential for irrigation and rural water supply. However, their efficiency...
Electric power systems are among the greatest achievements of the last century. Today, important issues, such as an ever-increasing demand, the flexible and reliable integration of distributed generation or a growth in disturbing loads, must be borne...
This paper aims to review the engineering controls for indoor air quality (IAQ) from a systems design perspective. As a result of the review, we classify the literature content into three categories: (1) indoor air treatments, (2) dissemination contr...
The Unified Power Quality Conditioner (UPQC) is one of the Custom Power devices (CP), and it mitigates both load current and supply voltage problems (voltage swells, sags, harmonics, etc.) simultaneously. By using CP, we are getting more familiar wit...
Although various quality by design (QbD) approaches have been used to establish a design space to obtain robust drug formulation and process parameters, the effect of excipient variability on the design space and drug product quality is unclear. In t...
Nowadays, the proliferation of distributed renewable energy sources is a fact. A microgrid is a good solution to self-manage the energy generation and consumption of electrical loads and sources from the point of view of the consumer as well as the p...
Though many scholars and practitioners are paying more attention to the health and life of the public after the COVID-19 outbreak, extant literature has so far failed to explore the variation of ambient air quality during this pandemic. The current s...
This note presents an optimal design method to enhance image quality in optical image stabilization (OIS) systems. First of all, performance limitations of conventional methods are shown and secondly, a new design framework based on convex optimizati...
Inspired by the United States Pharmacopoeia (USP) “monograph modernization” initiative, we developed and validated an assay for foscarnet sodium injection solution (“foscavir”), following quality by design (QbD) principles, incorporating design of ex...
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