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1,075 Results Found

  • Article
  • Open Access
15 Citations
4,479 Views
20 Pages

Working at height, and especially on construction scaffolding, is one of the most accident-prone situations on a construction site. The article attempts to assess the state of threat of working on scaffolding on the basis of the proposed coefficients...

  • Article
  • Open Access
63 Citations
6,032 Views
11 Pages

1 January 2018

This article presents the developed methodology of classifying and evaluating the causes of accidents involving construction scaffolding. This methodology allows the causes of accidents to be identified, classified into generic groups, and also allow...

  • Article
  • Open Access
2,558 Views
16 Pages

3 September 2021

Building scaffoldings are temporary structures that are commonly used in the construction industry. A precise determination of the number of building scaffoldings in use is a very complex task. The literature survey showed that there is a lack of sci...

  • Article
  • Open Access
35 Citations
9,160 Views
13 Pages

Dental Pulp Stem Cell-Derived, Scaffold-Free Constructs for Bone Regeneration

  • Fukushima Tatsuhiro,
  • Tatehara Seiko,
  • Takebe Yusuke,
  • Tokuyama-Toda Reiko and
  • Satomura Kazuhito

In the present study, a scaffold-free tissue construct was developed as an approach for the regeneration of tissue defects, which produced good outcomes. We fabricated a scaffold-free tissue construct from human dental pulp stem cells (hDPSCs constru...

  • Article
  • Open Access
22 Citations
10,065 Views
23 Pages

24 September 2020

The value, care, and customs of workers are essential in terms of occupational health and safety. The abuse of alcohol is widely regarded as a serious threat to the lives, health, and safety of employees. The aim of the research was to identify the m...

  • Article
  • Open Access
29 Citations
5,387 Views
18 Pages

Efficient Fabrication of Polycaprolactone Scaffolds for Printing Hybrid Tissue-Engineered Constructs

  • Enrique Sodupe Ortega,
  • Andres Sanz-Garcia,
  • Alpha Pernia-Espinoza and
  • Carmen Escobedo-Lucea

18 February 2019

Hybrid constructs represent substantial progress in tissue engineering (TE) towards producing implants of a clinically relevant size that recapitulate the structure and multicellular complexity of the native tissue. They are created by interlacing pr...

  • Article
  • Open Access
1 Citations
1,074 Views
26 Pages

Construction material management is crucial for project progression. Counting massive amounts of scaffold components is a key step for efficient material management. However, traditional counting methods are time-consuming and laborious. Utilizing a...

  • Article
  • Open Access
4 Citations
2,624 Views
20 Pages

20 July 2023

Selecting the appropriate temporary facilities is important for reducing cost and improving the productivity and safety of craft professionals in construction projects. However, the manual planning process for scaffolding systems is typically prone t...

  • Article
  • Open Access
19 Citations
6,117 Views
17 Pages

This study aimed to reveal opinion leaders who could impact their coworkers’ safety-related performance in Chinese construction teams. Questionnaires were distributed to 586 scaffolders in Wuhan to understand their opinions about influencing th...

  • Article
  • Open Access
2 Citations
914 Views
22 Pages

16 March 2025

In the construction of super high-rise buildings, vibration monitoring of climbing scaffolding is crucial for ensuring construction safety. This study proposes a vibration state prediction model based on Variational Mode Decomposition (VMD) and Tempo...

  • Article
  • Open Access
1,086 Views
22 Pages

27 September 2025

Following the significant disruption of traditional teaching by the COVID-19 pandemic, gamified education—an approach integrating technology and cognitive strategies—has gained widespread attention and use among educators and learners. Th...

  • Article
  • Open Access
48 Citations
17,350 Views
15 Pages

Scaffold Sheet Design Strategy for Soft Tissue Engineering

  • Richard T. Tran,
  • Paul Thevenot,
  • Yi Zhang,
  • Dipendra Gyawali,
  • Liping Tang and
  • Jian Yang

24 February 2010

Creating heterogeneous tissue constructs with an even cell distribution and robust mechanical strength remain important challenges to the success of in vivo tissue engineering. To address these issues, we are developing a scaffold sheet tissue engine...

  • Article
  • Open Access
15 Citations
3,583 Views
26 Pages

Osteogenic Potential of Sheep Mesenchymal Stem Cells Preconditioned with BMP-2 and FGF-2 and Seeded on an nHAP-Coated PCL/HAP/β-TCP Scaffold

  • Sandra Stamnitz,
  • Agnieszka Krawczenko,
  • Urszula Szałaj,
  • Żaneta Górecka,
  • Agnieszka Antończyk,
  • Zdzisław Kiełbowicz,
  • Wojciech Święszkowski,
  • Witold Łojkowski and
  • Aleksandra Klimczak

31 October 2022

Mesenchymal stem cells (MSCs) attract interest in regenerative medicine for their potential application in bone regeneration. However, direct transplantation of cells into damaged tissue is not efficient enough to regenerate large bone defects. This...

  • Article
  • Open Access
10 Citations
84,041 Views
23 Pages

5 January 2022

The substrate-independence theory utilizes sensemaking techniques to provide cognitively based scaffolds that guide and structure learning. Scaffolds are cognitive abstractions of constraints that relate to information within a system. The substrate-...

  • Article
  • Open Access
1,190 Views
20 Pages

Monitoring Method and Performance Analysis of Climbing Scaffolds in Super High-Rise Buildings Based on BeiDou/GNSS Technology

  • Pengfei Wang,
  • Gen Liu,
  • Jian Wang,
  • Ping Zhu,
  • Jiaqi Guo,
  • Jingxuan Zhang,
  • Heyu Zhang and
  • Yijia Liu

Monitoring the stability and safety of climbing scaffolds in super-high-rise construction is critical to ensuring construction quality and worker safety. This study proposes a Global Navigation Satellite System (GNSS)-based real-time monitoring metho...

  • Review
  • Open Access
33 Citations
5,841 Views
23 Pages

Osteoarthritis (OA) is a major joint disease that promotes locomotor deficiency during the middle- to old-age, with the associated disability potentially decreasing quality of life. Recently, surgical strategies to reconstruct both articular cartilag...

  • Article
  • Open Access
934 Views
28 Pages

Study of the Effectiveness of Skin Restoration Using a Biopolymer Hydrogel Scaffold with Encapsulated Mesenchymal Stem Cells

  • Marfa N. Egorikhina,
  • Lidia B. Timofeeva,
  • Yulia P. Rubtsova,
  • Ekaterina A. Farafontova,
  • Dariya D. Linkova,
  • Irina N. Charykova,
  • Maksim G. Ryabkov,
  • Anna A. Ezhevskaya,
  • Ekaterina A. Levicheva and
  • Diana Ya. Aleynik

14 August 2025

Improving the restoration of skin defects of various etiologies continues to be an important medical challenge globally. This primarily applies to the treatment of chronic wounds and major burns, which create particularly complex and socially signifi...

  • Review
  • Open Access
475 Citations
32,229 Views
43 Pages

Metallic Scaffolds for Bone Regeneration

  • Kelly Alvarez and
  • Hideo Nakajima

23 July 2009

Bone tissue engineering is an emerging interdisciplinary field in Science, combining expertise in medicine, material science and biomechanics. Hard tissue engineering research is focused mainly in two areas, osteo and dental clinical applications. Th...

  • Article
  • Open Access
6 Citations
7,372 Views
24 Pages

At construction sites, various types of temporary equipment and structures are used for safety and work efficiency. However, various temporary equipment-related accidents frequently occur for many reasons, including inappropriate installation, usage,...

  • Article
  • Open Access
6 Citations
3,808 Views
16 Pages

Functionalized Electrospun Scaffold–Human-Muscle-Derived Stem Cell Construct Promotes In Vivo Neocartilage Formation

  • Lina Jankauskaite,
  • Mantas Malinauskas,
  • Lauryna Aukstikalne,
  • Lauryna Dabasinskaite,
  • Augustinas Rimkunas,
  • Tomas Mickevicius,
  • Alius Pockevičius,
  • Edvinas Krugly,
  • Dainius Martuzevicius and
  • Arvydas Usas
  • + 2 authors

19 June 2022

Polycaprolactone (PCL) is a non-cytotoxic, completely biodegradable biomaterial, ideal for cartilage tissue engineering. Despite drawbacks such as low hydrophilicity and lack of functional groups necessary for incorporating growth factors, it provide...

  • Article
  • Open Access
8 Citations
4,612 Views
22 Pages

Biocompatibility Study of Hydrogel Biopolymer Scaffold with Encapsulated Mesenchymal Stem Cells

  • Marfa N. Egorikhina,
  • Lidia B. Timofeeva,
  • Daria D. Linkova,
  • Yulia P. Rubtsova,
  • Marina L. Bugrova,
  • Irina N. Charykova,
  • Maxim G. Ryabkov,
  • Irina I. Kobyakova,
  • Ekaterina A. Farafontova and
  • Diana Y. Aleynik

7 March 2023

One of the key and actively developing areas of regenerative medicine is tissue-engineering. There is no doubt that the use of tissue-engineering products can have a significant impact on the efficiency of repair of damaged tissues and organs. Howeve...

  • Proceeding Paper
  • Open Access
1 Citations
1,038 Views
7 Pages

Bioengineering of Mesenchymal-Stromal-Cell-Based 3D Constructs with Different Cell Organizations

  • Natalia Trufanova,
  • Oleh Trufanov,
  • Galyna Bozhok,
  • Ruslana Oberemok,
  • Olena Revenko and
  • Oleksandr Petrenko

17 February 2025

Standard 2D cultures inadequately mimic the natural microenvironment of mesenchymal stromal cells (MSCs), compromising their properties. This study investigated the impact of 3D cultures in spheroids, alginate microspheres (AMSs), and blood plasma sc...

  • Article
  • Open Access
3 Citations
2,433 Views
19 Pages

Specifics of Cryopreservation of Hydrogel Biopolymer Scaffolds with Encapsulated Mesenchymal Stem Cells

  • Marfa N. Egorikhina,
  • Yulia P. Rubtsova,
  • Daria D. Linkova,
  • Irina N. Charykova,
  • Ekaterina A. Farafontova and
  • Diana Ya. Aleinik

15 January 2024

The demand for regenerative medicine products is growing rapidly in clinical practice. Unfortunately, their use has certain limitations. One of these, which significantly constrains the widespread distribution and commercialization of such materials,...

  • Article
  • Open Access
1 Citations
3,667 Views
71 Pages

6 March 2025

Bridge construction equipment (BCE) is crucial for efficiently executing large-scale infrastructure projects, particularly those involving continuous long-span bridges. Current BCE technologies, like the Overhead Movable Scaffolding System (OMSS), ar...

  • Article
  • Open Access
51 Citations
7,418 Views
22 Pages

12 December 2022

About 40% of the US construction workforce experiences high-level fatigue, which leads to poor judgment, increased risk of injuries, a decrease in productivity, and a lower quality of work. Therefore, it is essential to monitor fatigue to reduce its...

  • Article
  • Open Access
66 Citations
13,609 Views
16 Pages

Dual-Scale Polymeric Constructs as Scaffolds for Tissue Engineering

  • Carlos Mota,
  • Dario Puppi,
  • Dinuccio Dinucci,
  • Cesare Errico,
  • Paulo Bártolo and
  • Federica Chiellini

1 March 2011

This research activity was aimed at the development of dual-scale scaffolds consisting of three-dimensional constructs of aligned poly(ε-caprolactone) (PCL) microfilaments and electrospun poly(lactic-co-glycolic acid) (PLGA) fibers. PCL constructs co...

  • Article
  • Open Access
20 Citations
4,580 Views
19 Pages

Development of 3D Hepatic Constructs Within Polysaccharide-Based Scaffolds with Tunable Properties

  • Marie-Noëlle Labour,
  • Camile Le Guilcher,
  • Rachida Aid-Launais,
  • Nour El Samad,
  • Soraya Lanouar,
  • Teresa Simon-Yarza and
  • Didier Letourneur

Organoids production is a key tool for in vitro studies of physiopathological conditions, drug-induced toxicity assays, and for a potential use in regenerative medicine. Hence, it prompted studies on hepatic organoids and liver regeneration. Numerous...

  • Article
  • Open Access
2 Citations
2,116 Views
10 Pages

Construction of Thick Myocardial Tissue through Layered Seeding in Multi-Layer Nanofiber Scaffolds

  • Yuru You,
  • Feng Xu,
  • Lingling Liu,
  • Songyue Chen,
  • Zhengmao Ding and
  • Daoheng Sun

22 September 2024

A major challenge in myocardial tissue engineering is replicating the heart’s highly complex three-dimensional (3D) anisotropic structure. Heart-on-a-chip (HOC) is an emerging technology for constructing myocardial tissue in vitro in recent yea...

  • Article
  • Open Access
12 Citations
3,147 Views
11 Pages

Jawbones Scaffold Constructed by TGF-β1 and BMP-2 Loaded Chitosan Microsphere Combining with Alg/HA/ICol for Osteogenic-Induced Differentiation

  • Yongxin Tan,
  • Liqun Zhang,
  • Muhammad Shahid Riaz Rajoka,
  • Zhanhua Mai,
  • Ali Bahadur,
  • Hafiza Mahreen Mehwish,
  • Muhammad Umair,
  • Liqing Zhao,
  • Yiguang Wu and
  • Xun Song

13 September 2021

Bone scaffolds based on multi-components are the leading trend to address the multifaceted prerequisites to repair various bone defects. Chitosan is the most useable biopolymer, having excellent biological applications. Therefore, in the present stud...

  • Article
  • Open Access
11 Citations
5,010 Views
13 Pages

Construction of Whole Genomes from Scaffolds Using Single Cell Strand-Seq Data

  • Mark Hills,
  • Ester Falconer,
  • Kieran O’Neill,
  • Ashley D. Sanders,
  • Kerstin Howe,
  • Victor Guryev and
  • Peter M. Lansdorp

Accurate reference genome sequences provide the foundation for modern molecular biology and genomics as the interpretation of sequence data to study evolution, gene expression, and epigenetics depends heavily on the quality of the genome assembly use...

  • Article
  • Open Access
327 Views
14 Pages

Enhanced Bone Regeneration by Scaffold-Free Three-Dimensional Constructs of Human Dental Pulp Stem Cells in a Rat Mandibular Defect Model

  • Monika Nakano,
  • Yasuyuki Fujii,
  • Yuri Matsui-Chujo,
  • Kazuhiro Nishimaki,
  • Yudai Miyazaki,
  • Yoko Torii,
  • Yurika Ikeda-Dantsuji,
  • Ayano Hatori,
  • Tatsuya Shimizu and
  • Yoko Kawase-Koga
  • + 3 authors

Bone defects in the maxillofacial region severely impair patient function and esthetics. Free autologous bone grafting remains the gold-standard treatment; however, surgical intervention at donor sites limits clinical applicability. Treatment using a...

  • Article
  • Open Access
14 Citations
3,240 Views
15 Pages

29 May 2022

This article proposes a methodology for classifying occupational accidents involving scaffolding based on the knowledge of the causes that led to their occurrence. Each occupational accident is caused by several causes belonging to three generic grou...

  • Article
  • Open Access
11 Citations
3,023 Views
14 Pages

26 August 2020

Surface topography and chemical characteristics can regulate stem cell proliferation and differentiation, and decrease the bone-healing time. However, the synergetic function of the surface structure and chemical cues in bone-regeneration repair was...

  • Article
  • Open Access
22 Citations
5,236 Views
15 Pages

5 September 2019

Bone is based on an elaborate system of mineralization and vascularization. In hard tissue engineering, diverse biomaterials compatible with osteogenesis and angiogenesis have been developed. In the present study, to examine the processes of osteogen...

  • Article
  • Open Access
53 Citations
9,228 Views
16 Pages

A Hyaluronan-Based Scaffold for the in Vitro Construction of Dental Pulp-Like Tissue

  • Letizia Ferroni,
  • Chiara Gardin,
  • Stefano Sivolella,
  • Giulia Brunello,
  • Mario Berengo,
  • Adriano Piattelli,
  • Eriberto Bressan and
  • Barbara Zavan

2 March 2015

Dental pulp tissue supports the vitality of the tooth, but it is particularly vulnerable to external insults, such as mechanical trauma, chemical irritation or microbial invasion, which can lead to tissue necrosis. In the present work, we present an...

  • Review
  • Open Access
28 Citations
5,180 Views
57 Pages

Construction of Non-Biaryl Atropisomeric Amide Scaffolds Bearing a C–N Axis via Enantioselective Catalysis

  • Xiao Xiao,
  • Biao Chen,
  • Yi-Ping Yao,
  • Hai-Jie Zhou,
  • Xu Wang,
  • Neng-Zhong Wang and
  • Fen-Er Chen

4 October 2022

The significant scaffold offered by atropisomeric amides with a C–N chiral axis has been extensively utilized for pharmaceuticals, agricultural science, and organic syntheses. As a result, the field of atropisomer synthesis has attracted consid...

  • Article
  • Open Access
11 Citations
6,141 Views
14 Pages

21 December 2016

One of the biggest challenges for tissue engineering is to efficiently provide oxygen and nutrients to cells on a three-dimensional (3D) engineered scaffold structure. Thus, achieving sufficient vascularization of the structure is a critical problem...

  • Article
  • Open Access
3 Citations
4,296 Views
19 Pages

Isolation, Characterization, and Agent-Based Modeling of Mesenchymal Stem Cells in a Bio-construct for Myocardial Regeneration Scaffold Design

  • Diana Victoria Ramírez López,
  • María Isabel Melo Escobar,
  • Carlos A. Peña-Reyes,
  • Álvaro J. Rojas Arciniegas and
  • Paola Andrea Neuta Arciniegas

19 May 2019

Regenerative medicine involves methods to control and modify normal tissue repair processes. Polymer and cell constructs are under research to create tissue that replaces the affected area in cardiac tissue after myocardial infarction (MI). The aim o...

  • Article
  • Open Access
15 Citations
6,264 Views
10 Pages

Manipulating Living Cells to Construct a 3D Single-Cell Assembly without an Artificial Scaffold

  • Aoi Yoshida,
  • Shoto Tsuji,
  • Hiroaki Taniguchi,
  • Takahiro Kenmotsu,
  • Koichiro Sadakane and
  • Kenichi Yoshikawa

30 July 2017

Artificial scaffolds such as synthetic gels or chemically-modified glass surfaces that have often been used to achieve cell adhesion are xenobiotic and may harm cells. To enhance the value of cell studies in the fields of regenerative medicine and ti...

  • Article
  • Open Access
7 Citations
2,821 Views
15 Pages

Novel Approach to the Construction of Fused Indolizine Scaffolds: Synthesis of Rosettacin and the Aromathecin Family of Compounds

  • Shohta Mizuno,
  • Takashi Nishiyama,
  • Mai Endo,
  • Koharu Sakoguchi,
  • Takaki Yoshiura,
  • Hana Bessho,
  • Toshio Motoyashiki,
  • Noriyuki Hatae and
  • Tominari Choshi

Camptothecin-like compounds are actively employed as anticancer drugs in clinical treatments. The aromathecin family of compounds, which contains the same indazolidine core structure as the camptothecin family of compounds, is also expected to displa...

  • Article
  • Open Access
1 Citations
2,129 Views
19 Pages

5 October 2021

A 4-nitro-L-phenylalanine scaffold was used to construct effective ion pair receptors capable of binding anions in an enhanced manner with the assistance of alkali metal cations. A benzocrown ether was linked to a receptor platform via the amide func...

  • Review
  • Open Access
3 Citations
2,535 Views
18 Pages

Next-Generation Biomaterials for Load-Bearing Tissue Interfaces: Sensor-Integrated Scaffolds and Mechanoadaptive Constructs for Skeletal Regeneration

  • Rahul Kumar,
  • Kyle Sporn,
  • Pranay Prabhakar,
  • Phani Paladugu,
  • Akshay Khanna,
  • Alex Ngo,
  • Chirag Gowda,
  • Ethan Waisberg,
  • Ram Jagadeesan and
  • Alireza Tavakkoli
  • + 1 author

Advancements in load-bearing tissue repair increasingly demand biomaterials that not only support structural integrity but also interact dynamically with the physiological environment. This review examines the latest progress in smart biomaterials de...

  • Article
  • Open Access
15 Citations
3,147 Views
15 Pages

Design, Construction, and Characterization of a New Regioisomer and Diastereomer Material Based on the Spirooxindole Scaffold Incorporating a Sulphone Function

  • Abdullah Mohammed Al-Majid,
  • Saied M. Soliman,
  • Matti Haukka,
  • M. Ali,
  • Mohammad Shahidul Islam,
  • Mohammed Rafi Shaik and
  • Assem Barakat

10 August 2020

The 1,3-dipolar cycloaddition reaction is one of the most rapid, and efficient protocols to access, and construct highly divergent heterocycle chiral auxiliaries. Free catalyst synthesis of spirooxindole scaffold incorporating sulphone moiety via one...

  • Article
  • Open Access
7 Citations
3,861 Views
19 Pages

Experimental Investigations on Ultimate Behavior of Fabricated Mobile Scaffolds

  • Heesoo Kim,
  • Jeonghyeon Lim,
  • Jeonghwa Lee,
  • Young Jong Kang and
  • Seungjun Kim

21 May 2021

A fabricated mobile scaffold has various components, including vertical members, horizontal members, braces, work plates, and castor wheels. In Korea, the structural performance of each member must be validated based on member-level structural safety...

  • Article
  • Open Access
3 Citations
4,852 Views
18 Pages

Does Europe Need an EU Product Safety Directive for Access Scaffolding?

  • Juan Carlos Rubio-Romero,
  • Manuel Suárez-Cebador,
  • María del Carmen Pardo-Ferreira,
  • José María De la Varga-Salto and
  • Jesús Antonio Carrillo-Castrillo

The main requirement established for the development of European Union product safety directives is to ensure a high level of safety for users. This research aims to analyze whether Europe needs a product safety directive for scaffolding and identify...

  • Review
  • Open Access
48 Citations
21,449 Views
42 Pages

Whole Organ Engineering: Approaches, Challenges, and Future Directions

  • Sogu Sohn,
  • Maxwell Van Buskirk,
  • Michael J. Buckenmeyer,
  • Ricardo Londono and
  • Denver Faulk

22 June 2020

End-stage organ failure remains a leading cause of morbidity and mortality across the globe. The only curative treatment option currently available for patients diagnosed with end-stage organ failure is organ transplantation. However, due to a critic...

  • Article
  • Open Access
46 Citations
10,790 Views
12 Pages

Since most of the body’s extracellular matrix (ECM) is composed of collagen and elastin, we believe the choice of these materials is key for the future and promise of tissue engineering. Once it is known how elastin content of ECM guides cellul...

  • Article
  • Open Access
7 Citations
5,154 Views
15 Pages

A traditional structural analysis of scaffolding structures requires loading conditions that are only possible during design, but not in operation. Thus, this study proposes a method that can be used during operation to make an automated safety predi...

  • Review
  • Open Access
32 Citations
14,135 Views
16 Pages

6 July 2023

Cultured meat is a new type of green, safe, healthy, and sustainable alternative to traditional meat that will potentially alleviate the environmental impact of animal farming and reduce the requirement for animal slaughter. However, the cultured mea...

  • Article
  • Open Access
18 Citations
6,803 Views
23 Pages

Purpose: Construction workers’ reactions to safety-related issues during operation vary from person to person due to their different occupational levels, which can be attributed to various influencing factors and their correspondingly complicat...

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