In recent years, matrix-assisted laser desorption/ionization (MALDI) has become the main tool for the study of biological macromolecules, such as protein nano-machines, especially in the determination of their molecular masses, structure, and post-tr...
Laser desorption/ionization techniques, such as matrix-assisted laser desorption/ionization (MALDI) and surface-assisted laser desorption/ionization (SALDI), are the basis of modern mass spectrometry, enabling the analysis of a wide range of chemical...
Marine bioactive metabolites are often heterogeneously expressed in tissues both spatially and over time. Therefore, traditional solvent extraction methods benefit from an understanding of the in situ sites of biosynthesis and storage to deal with h...
Nanostructures-assisted laser desorption/ionization mass spectrometry (NALDI-MS) is gaining attention for the analysis of a wide range of molecules. In this present investigation, Pseudostaurosira trainorii mediated biosynthesized iron-oxide nanopart...
In the context of growing vulnerabilities, cyber-risk management cannot rely on a one-off approach, instead calling for a continuous re-assessment of the risk and adaptation of risk management strategies. Under the mixed investment–insurance ap...
In this work, a commercial paraffin PCM (RT35) characterized by a change range of the solid-liquid phase transition temperature Ts−l=29–36 °C and the low thermal conductivity λSL=0.2 W/m K is experimentally tested by submitting...
The increasing volume and velocity of the continuously generated data (data stream) challenge machine learning algorithms, which must evolve to fit real-world problems. The data stream clustering algorithms face issues such as the rapidly increasing...
The COVID-19 pandemic has led to unprecedented demand on the global healthcare system. Remarkably, at the end of 2021, COVID-19 vaccines received approvals for human use in several countries worldwide. Since then, a solid base for response in the fig...
Exploiting the tumor environment features (EPR effect, elevated glutathione, reactive oxygen species levels) might allow attaining a selective and responsive carrier capable of improving the therapeutic outcome. To this purpose, the in situ covalent...
11 March 2022
The Industry 4.0 paradigm represents the fourth industrial revolution, embodied by the marriage between information and communication technologies and manufacturing. Assessment campaigns are conducted to examine the status of deployment of that parad...
The development of the hyperspectral remote sensor technology allows the acquisition of images with a very detailed spectral information for each pixel. Because of this, hyperspectral images (HSI) potentially possess larger capabilities in solving ma...
Strigiformes are affected by a substantial decline mainly caused by habitat loss and destruction, poaching, and trapping. Moreover, the increasing trend in bird trade and the growing interest in wild-caught rather than captive-bred birds are expected...
Slowed information processing speed (IPS) is the hallmark and first cognitive domain to be altered in multiple sclerosis (MS) patients. Insufficient serum vitamin D was previously associated with disease development, relapses, and progression, but li...
Networks and graphs offer a suitable and powerful framework for studying the spread of infection in human and animal populations. In the case of a heterogeneous population, the social contact network has a pivotal role in the analysis of directly tra...
Image segmentation is an essential but critical component in low level vision, image analysis, pattern recognition, and now in robotic systems. In addition, it is one of the most challenging tasks in image processing and determines the quality of the...
Hyponatremia, i.e., the presence of a serum sodium concentration ([Na+]) < 136 mEq/L, is the most frequent electrolyte imbalance in the elderly and in hospitalized patients. Symptoms of acute hyponatremia, whose main target is the central nervous...
SARS-CoV-2, an enveloped, single-stranded RNA virus causing COVID-19, exerts morbidity and mortality especially in elderly, obese individuals and those suffering from chronic conditions. In addition to the availability of vaccines and the limited eff...
The Proviral Integration site for the Moloney murine leukemia virus (PIM)-1 kinase and its family members (PIM-2 and PIM-3) regulate several cellular functions including survival, proliferation, and apoptosis. Recent studies showed their involvement...
Mass customization (MC) has become a pivotal manufacturing strategy for addressing the growing demand for personalized products without compromising cost efficiency and scalability. The emergence of Industry 4.0 (I4.0) has further expanded the potent...
In this work, the seasonal performance of a dual-source heat pump (DSHP) prototype, able to exploit aerothermal and geothermal energy, was assessed experimentally. The unit, operated under the working conditions of two representative heating days (RD...
Data spaces are increasingly recognized as a key enabler of secure, sovereign, and interoperable data exchange across manufacturing and supply chain networks. Despite growing institutional interest in Europe, academic research on this topic lacks a c...
Background: Gastric cancer (GC) is a malignant tumor of the gastrointestinal tract, characterized by high mortality rates and responsible for about one million new cases each year globally. Surgery is the main treatment, but achieving radical resecti...
The pathophysiology of cognitive impairment (CI) in multiple sclerosis (MS) remains unclear. Meningeal B cell aggregates may contribute to cortical grey matter pathology. Cerebrospinal fluid (CSF), kappa free light chains (KFLC), and KFLCs-Index (kap...
The expected utility principle is often used to compute the insurance premium through a second-order approximation of the expected value of the utility of losses. We investigate the impact of using a more accurate approximation based on the fourth-or...
The kinds of interactions taking place in an online personal finance forum and the sentiments expressed in its posts may influence the diffusion and usefulness of those forums. We explore a set of major threads on a personal finance forum to assess t...
The most accurate method for the design and the simulation of a borehole heat exchanger (BHE) field is employing the fluid-to-ground thermal response of the field, namely the mean-fluid-temperature rise produced by a time-constant thermal power suppl...
23 August 2020
(1) Background: The aim of this study is to establish which specific elements of the built environment can contribute to improving the physical activity of self-sufficient, noninstitutionalized and living in the city adults > 65 years. (2) Methods...
The influence of emitters, heat pump size and building envelope thermal inertia was investigated on the energy consumption of a heat pump-based heating system with a numerical study performed with the dynamic software TRNSYS. An algorithm based on a...
Ground-coupled heat pump (GCHP) systems usually utilize buried vertical heat exchangers, named borehole heat exchangers (BHEs). The accurate design or simulation of a GCHP system requires the calculation of the time-dependent outlet temperature from...
Spleen tyrosine kinase (SYK) can behave as an oncogene or a tumor suppressor, depending on the cell and tissue type. As pharmacological SYK inhibitors are currently evaluated in clinical trials, it is important to gain more information on the molecul...
Despite Alzheimer’s disease (AD) incidence being projected to increase worldwide, the drugs currently on the market can only mitigate symptoms. Considering the failures of the classical paradigm “one target-one drug-one disease” in delivering effecti...
Ground-coupled heat pumps usually employ fields of borehole heat exchangers (BHEs), which must be designed by suitable models. In order to validate a BHE model, it is advisable to compare the computation results with experimental data. A well-known d...
Investments in security and cyber-insurance are two cyber-risk management strategies that can be employed together to optimize the overall security expense. In this paper, we provide a closed form for the optimal investment under a full set of insura...
Ovarian cancer remains the leading cause of mortality among gynecological tumors. Estrogen receptor beta (ERβ) expression has been suggested to act as a tumor suppressor in epithelial ovarian cancer by reducing both tumor growth and metastasis....
Men with nonalcoholic fatty liver disease (NAFLD) are more exposed to nonalcoholic steatohepatitis (NASH) and liver fibrosis than women. However, the underlying molecular mechanisms of NALFD sex dimorphism are unclear. We combined gene expression, hi...
A combination of flash chromatography, solid phase extraction, high-performance liquid chromatography, and in vitro bioassays was used to isolate phytocomponents endowed with anticholinesterase activity in extract from Phyllanthus muellarianus. Phyto...
The psychological impact of the pandemic on healthcare workers has been assessed worldwide, but there are limited data on how mental health professionals (MHPs) have been affected. Thus, this paper aims to investigate anxiety, post-traumatic stress,...
In the last years, the connection between the endocannabinoid system (eCS) and neuroprotection has been discovered, and evidence indicates that eCS signaling is involved in the regulation of cognitive processes and in the pathophysiology of Alzheimer...
The European Parliament has imposed to reduce by 2030 whole HFC emissions by at least two-thirds with respect to 2014 levels. With the aim of contributing to determine the energy and environmental advantages of refrigerants alternative to R-410A, thi...
Correlation in cyber risk represents an additional source of concern for utility and industrial infrastructures, where risks may be introduced by connected systems. A major means of reducing risk is to transfer it through insurance. In this paper, we...
Aggressive neuromyelitis optica spectrum disorders (NMOSDs) with antibodies (Abs) against aquaporin-4 (AQP4) can be treated by blocking the interleukin 6 (IL6) pathways with tocilizumab. This IL6-inhibitor was employed to treat coronavirus disease 20...
In cancer patients, hyponatremia is detected in about 40% of cases at hospital admission and has been associated to a worse outcome. We have previously observed that cancer cells from different tissues show a significantly increased proliferation rat...
Trade embargoes, often imposed for political, economic, or security reasons, have long been a tool of international diplomacy. Transshipments may be employed as a strategic mechanism by nations and organizations to circumvent trade embargoes. Transsh...
Preferentially Expressed Antigen in Melanoma (PRAME), a member of the cancer/testis antigen family, is central to the field of skin cancer diagnostics and therapeutics. As a nuclear receptor and transcriptional regulator, PRAME plays a critical role...
Background: Limited real-world data are available on upadacitinib drug survival in patients with atopic dermatitis (AD). Objectives: To investigate upadacitinib drug survival, and the reasons and predictors of drug discontinuation in AD patients. Met...
This paper proposes a business model for providing services based on the Internet of Things through a platform that intermediates between human users and Wireless Sensor Networks (WSNs). The platform seeks to maximize its profit through posting both...
Alzheimer’s disease still represents an untreated multifaceted pathology, and drugs able to stop or reverse its progression are urgently needed. In this paper, a series of naturally inspired chalcone-based derivatives was designed as structural...
A business model for sensor-based services is proposed where a platform creates a multi-sided market. The business model comprises a platform that serves as an intermediary between human users, app developers, and sensor networks, so that the users u...
Tilting pad journal bearings are usually employed in turbomachines for their stable behavior at high rotational speeds. Devoted test rigs have been realized to validate the predictions of theoretical models. However, the design of new high-performanc...
Service Level Agreements are employed to set availability commitments in cloud services. When a violation occurs as in an outage, cloud providers may be called to compensate customers for the losses incurred. Such compensation may be so large as to e...
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