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227 Results Found

  • Article
  • Open Access
19 Citations
6,892 Views
13 Pages

The Nine-Item Internet Gaming Disorder Scale (IGDS9-SF): Its Psychometric Properties among Sri Lankan Students and Measurement Invariance across Sri Lanka, Turkey, Australia, and the USA

  • Amira Mohammed Ali,
  • Rasmieh Al-Amer,
  • Maha Atout,
  • Tazeen Saeed Ali,
  • Ayman M. Hamdan Mansour,
  • Haitham Khatatbeh,
  • Abdulmajeed A. Alkhamees and
  • Amin Omar Hendawy

The prevalence of internet gaming disorders (IGD) is considerably high among youth, especially with the social isolation imposed by the ongoing COVID-19 pandemic. IGD adversely affects mental health, quality of life, and academic performance. The Int...

  • Review
  • Open Access
45 Citations
8,221 Views
19 Pages

Sexual Differences in Internet Gaming Disorder (IGD): From Psychological Features to Neuroanatomical Networks

  • Marilena Marraudino,
  • Brigitta Bonaldo,
  • Benedetto Vitiello,
  • Giovanna C. Bergui and
  • GianCarlo Panzica

16 February 2022

Internet gaming disorder (IGD) has been included in the 2013 Diagnostic and Statistical Manual of Mental Disorders (DSM-5) as a condition in need of further study, and gaming disorder was recognized by the World Health Organization as a mental disord...

  • Article
  • Open Access
27 Citations
6,731 Views
12 Pages

IgD is considered to be a recently-evolved Ig and a puzzling molecule, being previously found in all vertebrate taxa, except for birds. Although IgD likely plays an important role in vertebrate immune responses, the function of IgD in Nile tilapia (O...

  • Article
  • Open Access
13 Citations
6,117 Views
14 Pages

The Spanish Version of the Internet Gaming Disorder Scale-Short Form (IGDS9-SF): Further Examination Using Item Response Theory

  • Laura Maldonado-Murciano,
  • Halley M. Pontes,
  • Mark D. Griffiths,
  • Maite Barrios,
  • Juana Gómez-Benito and
  • Georgina Guilera

Internet gaming disorder (IGD) has been recognized by the American Psychiatric Association (APA) as a tentative disorder in the latest (fifth) revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). However, psychometric evalua...

  • Article
  • Open Access
89 Citations
14,918 Views
15 Pages

Spanish Validation of the Internet Gaming Disorder Scale–Short Form (IGDS9-SF): Prevalence and Relationship with Online Gambling and Quality of Life

  • Marta Beranuy,
  • Juan M. Machimbarrena,
  • M. Asunción Vega-Osés,
  • Xavier Carbonell,
  • Mark D. Griffiths,
  • Halley M. Pontes and
  • Joaquín González-Cabrera

Online gaming is a very common form of leisure among adolescents and young people, although its excessive and/or compulsive use is associated with psychological impairments in a minority of gamers. The latest (fifth) edition of the Diagnostic and Sta...

  • Article
  • Open Access
11 Citations
3,703 Views
11 Pages

Association between the Internet Gaming Disorder and Anxiety and Depression among University Students during COVID-19 Pandemic

  • Mohd Fariz Idris,
  • Suriati Mohamed Saini,
  • Shalisah Sharip,
  • Nur Farahaizan Idris and
  • Nur Fadilah Ab Aziz

Introduction: Internet gaming is now a major concern since its overuse has had a detrimental impact on people’s well-being. This study aims to investigate the association between Internet Gaming Disorder and depression, anxiety, and stress, as...

  • Article
  • Open Access
103 Citations
17,257 Views
11 Pages

Emotional Regulation in Young Adults with Internet Gaming Disorder

  • Ju-Yu Yen,
  • Yi-Chun Yeh,
  • Peng-Wei Wang,
  • Tai-Ling Liu,
  • Yun-Yu Chen and
  • Chih-Hung Ko

People diagnosed with Internet gaming disorder (IGD) have been frequently reported to experience depression, anxiety, and hostility. Emotional regulation contributes to these mood symptoms. This study evaluated emotional regulation in subjects with I...

  • Article
  • Open Access
6 Citations
2,997 Views
12 Pages

A new postmodern depression type, named “Modern-Type Depression” (MTD), is emerging in Western countries. MTD is often underdiagnosed, mainly due to potentially higher comorbidity with technology-based addictions, including Internet Gamin...

  • Article
  • Open Access
11 Citations
4,096 Views
12 Pages

(1) Background: Internet gaming disorder (IGD) in youths likely leads to disruptive mood dysregulation, especially among those with attention-deficit/hyperactivity disorder (ADHD). Whether IGD mediates the pathways leading ADHD to disruptive emotiona...

  • Review
  • Open Access
9 Citations
3,633 Views
22 Pages

Reliability Generalization Meta-Analysis of Internet Gaming Disorder Scale

  • Júlia Gisbert-Pérez,
  • Manuel Martí-Vilar,
  • César Merino-Soto and
  • Miguel Vallejos-Flores

11 October 2022

The objective of this study was to carry out a reliability generalization meta-analysis of the Internet Gaming Disorder Scale (IGDS) to find out if it presents adequate values that justify its application in its four versions: original and abbreviate...

  • Article
  • Open Access
5 Citations
4,512 Views
10 Pages

The paper aims to adjust the Taiwanese version of Internet gaming disorder-short form Likert scale with Likert (IGD-SF-T-L) based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria to a Likert scale model and test its psych...

  • Article
  • Open Access
91 Citations
8,379 Views
12 Pages

Prevalence and Interpersonal Correlates of Internet Gaming Disorders among Chinese Adolescents

  • Xue Yang,
  • Xuewen Jiang,
  • Phoenix Kit-han Mo,
  • Yong Cai,
  • Le Ma and
  • Joseph Tak-fai Lau

This study investigated the prevalence and interpersonal correlates of Internet gaming disorders (IGD) among Chinese adolescents. A cross-sectional survey was conducted in two cities (Shanghai and Xi’an) in China. A total of 2666 (Meanage = 12....

  • Article
  • Open Access
7 Citations
4,405 Views
8 Pages

Internet Gaming Disorder Does Not Predict Mood, Anxiety or Substance Use Disorders in University Students: A One-Year Follow-Up Study

  • Guilherme Borges,
  • Corina Benjet,
  • Ricardo Orozco,
  • Yesica Albor,
  • Eunice V. Contreras,
  • Iris R. Monroy-Velasco,
  • Praxedis C. Hernández-Uribe,
  • Patricia M. Báez-Mansur,
  • María A. Covarrubias Diaz Couder and
  • Nydia Machado
  • + 2 authors

We seek to evaluate whether Internet Gaming Disorder (IGD) among university students in Mexico during their first year at university predicts a long list of mental disorders a year later, controlling for baseline mental health disorders as well as de...

  • Article
  • Open Access
30 Citations
4,355 Views
14 Pages

Ample evidence indicates that peer victimization is a crucial risk factor for adolescent internet gaming disorder (IGD); however, little is known about the mechanisms underlying this association. Based on the risk-buffering model and self-determinati...

  • Article
  • Open Access
3 Citations
3,144 Views
16 Pages

Enhanced N-Glycan Profiling of Therapeutic Monoclonal Antibodies through the Application of Upper-Hinge Middle-Up Level LC-HRMS Analysis

  • Natalia Mesonzhnik,
  • Anton Belushenko,
  • Polina Novikova,
  • Alexey Kukharenko and
  • Mikhail Afonin

6 August 2024

Therapeutic monoclonal antibodies (mAbs) are crucial in modern medicine due to their effectiveness in treating various diseases. However, the structural complexity of mAbs, particularly their glycosylation patterns, presents challenges for quality co...

  • Article
  • Open Access
4 Citations
3,329 Views
12 Pages

Expanding the Anti-Phl p 7 Antibody Toolkit: An Anti-Idiotype Nanobody Inhibitor

  • Susan K. Vester,
  • Anna M. Davies,
  • Rebecca L. Beavil,
  • Balraj S. Sandhar,
  • Andrew J. Beavil,
  • Hannah J. Gould,
  • Brian J. Sutton and
  • James M. McDonnell

16 November 2023

We have previously produced a toolkit of antibodies, comprising recombinant human antibodies of all but one of the human isotypes, directed against the polcalcin family antigen Phl p 7. In this work, we complete the toolkit of human antibody isotypes...

  • Review
  • Open Access
4 Citations
5,942 Views
57 Pages

28 August 2024

Since game mechanics and their visual aspects have become more and more addictive, there is concern about the growing prevalence of Internet gaming disorder (IGD). In the current narrative review, we searched PubMed and Google Scholar databases for t...

  • Article
  • Open Access
3,456 Views
10 Pages

IgD+IgM B Cells in Common Variable Immunodeficiency

  • Taissa de M. Kasahara and
  • Sudhir Gupta

1 February 2024

Common variable immunodeficiency (CVID) is the most frequent form of primary hypogammaglobulinemia in adults. In addition to recurrent infections and respiratory manifestations, CVID patients may present several non-infection complications such as au...

  • Article
  • Open Access
5 Citations
4,823 Views
9 Pages

Excessive internet gaming in high prevalence is a very common problem that has been increasing in recent years, especially in teenagers and university students. However, there is a lack of psychometric evaluation for Internet Gaming Disorder in the L...

  • Article
  • Open Access
14 Citations
3,415 Views
10 Pages

Internet Gaming Disorder (IGD) has been included in the DSM-5 as a diagnosis for further study, and Gaming Disorder as a new diagnosis in the ICD-11. Nonetheless, little is known about the clinical prevalence of IGD in children and adolescents. Addit...

  • Article
  • Open Access
3 Citations
4,054 Views
24 Pages

In Search of Clinical Markers: Indicators of Exposure in Dampness and Mold Hypersensitivity Syndrome (DMHS)

  • Kirsi Vaali,
  • Kingsley Mokube Ekumi,
  • Maria A. Andersson,
  • Marika Mannerström and
  • Tuula Heinonen

7 March 2023

Potential markers were sought to diagnose mold hypersensitivity. Indoor air condensed water and human macrophage THP-1 test were applied to evaluate the buildings. Basophil activation tests (BAT) were conducted and mold-specific immunoglobulins (IgE,...

  • Review
  • Open Access
18 Citations
7,941 Views
13 Pages

4 August 2022

The World Health Organization recognizes internet gaming disorder (IGD) as a disorder that causes problems in daily life as a result of excessive interest in online games. The causes of IGD have become more apparent in recent years. Because of prolon...

  • Review
  • Open Access
1 Citations
2,617 Views
17 Pages

Rare plasma cell disorders—including IgD, IgE, and IgM multiple myeloma, non-secretory myeloma (NSMM), plasma cell leukemia (PCL), and heavy chain disease (HCD)—are biologically heterogeneous and often present with atypical features and a...

  • Article
  • Open Access
177 Citations
20,402 Views
13 Pages

Clinical Characteristics of Diagnosis for Internet Gaming Disorder: Comparison of DSM-5 IGD and ICD-11 GD Diagnosis

  • Yeong Seon Jo,
  • Soo Young Bhang,
  • Jung Seok Choi,
  • Hae Kook Lee,
  • Seung Yup Lee and
  • Yong-Sil Kweon

The American Psychiatric Association (APA) included internet game disorder (IGD) in section III of the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-5) on the condition that it guaranteed more clinical research and experien...

  • Article
  • Open Access
9 Citations
3,589 Views
23 Pages

Use of Energy-Based Domain Knowledge as Feedback to Evolutionary Algorithms for the Optimization of Water Distribution Networks

  • Diego Páez,
  • Camilo Salcedo,
  • Alexander Garzón,
  • María Alejandra González and
  • Juan Saldarriaga

4 November 2020

The optimization of water distribution networks (WDN) has evolved, requiring approaches that seek to reduce capital costs and maximize the reliability of the system simultaneously. Hence, several evolutionary algorithms, such as the non-dominated sor...

  • Article
  • Open Access
1 Citations
2,188 Views
7 Pages

Immunoglobulin D (IgD) myeloma represents an uncommon subtype of multiple myeloma (MM), accounting for 1–2% of cases. Subjects affected by IgD MM have been demonstrated to have an inferior outcome and survival compared to those with other MM su...

  • Review
  • Open Access
1 Citations
2,556 Views
19 Pages

Understanding the Immune System’s Intricate Balance: Activation, Tolerance, and Self-Protection

  • Jui-Yun Chen,
  • Li-Jane Shih,
  • Min-Tser Liao,
  • Kuo-Wang Tsai,
  • Kuo-Cheng Lu and
  • Wan-Chung Hu

Understanding the mechanisms of immune activation and deactivation is paramount. A host must initiate effective immunity against pathogenic infections while avoiding triggering immunity against self-antigens, which can lead to detrimental autoimmune...

  • Article
  • Open Access
3 Citations
3,208 Views
15 Pages

B Cells and Double-Negative B Cells (CD27IgD) Are Related to Acute Pancreatitis Severity

  • Filipa Malheiro,
  • Miguel Ângelo-Dias,
  • Teresa Lopes,
  • Sofia Azeredo-Lopes,
  • Catarina Martins and
  • Luis Miguel Borrego

5 January 2024

Acute pancreatitis (AP) is an increasingly frequent disease in which inflammation plays a crucial role. Fifty patients hospitalized with AP were included and peripheral blood samples were analyzed for B and T cell subpopulations at the time of hospit...

  • Article
  • Open Access
5 Citations
2,953 Views
25 Pages

Hypochlorous Acid and Chloramines Induce Specific Fragmentation and Cross-Linking of the G1-IGD-G2 Domains of Recombinant Human Aggrecan, and Inhibit ADAMTS1 Activity

  • Yihe Wang,
  • Astrid Hammer,
  • Gerald Hoefler,
  • Ernst Malle,
  • Clare L. Hawkins,
  • Christine Y. Chuang and
  • Michael J. Davies

8 February 2023

Atherosclerosis is a chronic inflammatory disease and a leading cause of mortality. It is characterized by arterial wall plaques that contain high levels of cholesterol and other lipids and activated leukocytes covered by a fibrous cap of extracellul...

  • Article
  • Open Access
11 Citations
5,330 Views
9 Pages

Psychometric Properties of the Malay Version of the Internet Gaming Disorder Scale-Short Form (IGDS9-SF-M): Evidence from a Sample of Malaysian Undergraduates

  • Shiao Ling Ling,
  • Nik Ruzyanei Nik Jaafar,
  • Kit-Aun Tan,
  • Norharlina Bahar,
  • Azlin Baharudin and
  • Ahmad Izzat Ahmad Tajjudin

In recent years, increased interest in Internet Gaming Disorder has led to the development of the Internet Gaming Disorder Scale-Short Form. Translation and subsequent validation of such a scale are important for cross-cultural use. The aim of the pr...

  • Article
  • Open Access
109 Citations
11,208 Views
11 Pages

Associations Among Resilience, Stress, Depression, and Internet Gaming Disorder in Young Adults

  • Ju-Yu Yen,
  • Huang-Chi Lin,
  • Wei-Po Chou,
  • Tai-Ling Liu and
  • Chih-Hung Ko

Background and Aims: Using gaming to escape emotional difficulty has been suggested to be a candidate mechanism contributing to Internet gaming disorder (IGD). This study evaluated the associations among resilience, perceived stress, depression, and...

  • Article
  • Open Access
19 Citations
5,839 Views
14 Pages

6 January 2019

Background: Resilience, an important protective factor against Internet gaming disorder (IGD), is the ability to recover from negative emotional experiences and constitutes a flexible adaptation to stress. Despite the importance of resilience in pred...

  • Article
  • Open Access
20 Citations
4,820 Views
12 Pages

9 September 2021

Background: Studies have shown that many Internet game players may have experienced Internet gaming disorder (IGD), which is thought to coexist with a variety of cognitive and psychological disorders, such as depression. A three-year, four-point long...

  • Article
  • Open Access
12 Citations
5,184 Views
8 Pages

Roles of Hostility and Depression in the Association between the MAOA Gene Polymorphism and Internet Gaming Disorder

  • Ju-Yu Yen,
  • Wei-Po Chou,
  • Huang-Chi Lin,
  • Hung-Chi Wu,
  • Wen-Xiang Tsai and
  • Chih-Hung Ko

The metabolism of bioamine in the central nervous system contributes to the development of addiction. We examined the roles of hostility and depression in the association between internet gaming disorder (IGD) and monoamine oxidase-A (MAOA) EcoRV pol...

  • Article
  • Open Access
4 Citations
3,004 Views
12 Pages

14 May 2023

Playing online games is gradually becoming mainstream entertainment, but some people may develop Internet gaming disorder (IGD). Like other behavioral addictive diseases, one of the main characteristics of IGD is a craving for games, which also makes...

  • Review
  • Open Access
15 Citations
4,687 Views
13 Pages

Host immunological pathways are delicate to cope with different types of pathogens. In this article, we divide immunological pathways into two groups: Immunoglobulin G-related eradicable immunities and Immunoglobulin A-related tolerable immunities. O...

  • Case Report
  • Open Access
3,821 Views
6 Pages

11 October 2023

Primary lymphomas of the salivary gland are rare. The most common subtype is MALT lymphoma. MALT lymphoma has an indolent clinical course, and patients often present with a prolonged history. Evaluations of parotid masses begin initially with radiolo...

  • Article
  • Open Access
3,066 Views
18 Pages

Human IgMhiCD300a+ B Cells Are Circulating Marginal Zone Memory B Cells That Respond to Pneumococcal Polysaccharides and Their Frequency Is Decreased in People Living with HIV

  • Joana Vitallé,
  • Olatz Zenarruzabeitia,
  • Aitana Merino-Pérez,
  • Iñigo Terrén,
  • Ane Orrantia,
  • Arantza Pacho de Lucas,
  • José A. Iribarren,
  • Lucio J. García-Fraile,
  • Luz Balsalobre and
  • Francisco Borrego
  • + 2 authors

6 September 2023

CD300a is differentially expressed among B cell subsets, although its expression in immunoglobulin (Ig)M+ B cells is not well known. We identified a B cell subset expressing CD300a and high levels of IgM (IgMhiCD300a+). The results showed that IgMhiC...

  • Article
  • Open Access
3 Citations
3,652 Views
18 Pages

22 December 2023

This paper provides an approach that addresses the negative social awareness of games and improves psychological and mental healing effects. It has been perceived that games can lead to reduced physical activity and psychological withdrawal. However,...

  • Article
  • Open Access
13 Citations
3,821 Views
20 Pages

Dietary Habits and Gaming Behaviors of Portuguese and Brazilian Esports Players

  • Fernando J. Ribeiro,
  • Raquel Teixeira and
  • Rui Poínhos

28 September 2023

As the esports industry grows, marketing campaigns for fast food, soft drinks, alcoholic and energy drinks, and dietary supplements at related events intensify. Portuguese and Brazilian esports players’ dietary patterns remain unexplored. This...

  • Article
  • Open Access
19 Citations
7,818 Views
14 Pages

B Cells and B Cell Blasts Withstand Cryopreservation While Retaining Their Functionality for Producing Antibody

  • Philipp Fecher,
  • Richard Caspell,
  • Villian Naeem,
  • Alexey Y. Karulin,
  • Stefanie Kuerten and
  • Paul V. Lehmann

31 May 2018

In individuals who have once developed humoral immunity to an infectious/foreign antigen, the antibodies present in their body can mediate instant protection when the antigen re-enters. Such antigen-specific antibodies can be readily detected in the...

  • Article
  • Open Access
85 Citations
12,412 Views
11 Pages

Background: This study aimed to explore relationships between impulsivity, interpersonal relationships, depression, and Internet Gaming Disorder (IGD) symptoms. Methods: A total of 118 young adults participated in this study: 67 IGD patients who met...

  • Article
  • Open Access
9 Citations
6,413 Views
14 Pages

Internet Gaming Disorder in Children and Adolescents with Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder

  • Valerio Simonelli,
  • Antonio Narzisi,
  • Gianluca Sesso,
  • Andrea Salvati,
  • Annarita Milone,
  • Valentina Viglione,
  • Greta Tolomei,
  • Gabriele Masi and
  • Stefano Berloffa

2 February 2024

Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) have been related to an increased risk for behavioral addictions including online gaming. However, the relationship between these two conditions and Internet gaming di...

  • Article
  • Open Access
28 Citations
7,961 Views
11 Pages

Internet Gaming Disorder in Children and Adolescents with Attention Deficit Hyperactivity Disorder

  • Stefano Berloffa,
  • Andrea Salvati,
  • Giulia D’Acunto,
  • Pamela Fantozzi,
  • Emanuela Inguaggiato,
  • Francesca Lenzi,
  • Annarita Milone,
  • Pietro Muratori,
  • Chiara Pfanner and
  • Gabriele Masi
  • + 5 authors

18 March 2022

Although Attention Deficit Hyperactivity Disorder (ADHD) has been related to an increased risk for behavioral addictions, the relationship between ADHD and Internet Gaming Disorder (IGD) is still debated. The aim of this study is to address this topi...

  • Feature Paper
  • Article
  • Open Access
1,809 Views
18 Pages

20 December 2023

With the increasing global emphasis on green development, industrial green development (IGD) has gradually gained attention as a crucial component of sustainable development. However, there is limited research evaluating and analyzing the IGD of citi...

  • Article
  • Open Access
20 Citations
7,119 Views
11 Pages

Objectives: The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) includes the diagnostic criteria for Internet gaming disorder (IGD). This study evaluated (1) the screening, diagnostic, and prevalence-estimated cutoff poin...

  • Article
  • Open Access
1,004 Views
18 Pages

30 June 2025

Internet gaming disorder (IGD) has been a prominent social problem throughout the world, causing various physical health issues, and interoceptive sensibility—the ability to perceive internal bodily signals—may be a key factor in this pro...

  • Article
  • Open Access
59 Citations
6,158 Views
13 Pages

Abundant empirical research indicates a relationship between parental psychological control and adolescent Internet gaming disorder (IGD), but the direction and underlying mechanism of this association remain unclear. Using a two-year longitudinal de...

  • Article
  • Open Access
4 Citations
2,774 Views
14 Pages

19 September 2024

While online gaming has become a choice for relaxation and entertainment in today’s digital age, Internet Gaming Disorder (IGD) has also become a widely concerning mental disorder. Nature connectedness has been found to effectively reduce addic...

  • Article
  • Open Access
12 Citations
4,616 Views
11 Pages

Internet gaming disorder (IGD) is significantly associated with depression across previous studies, and significantly affects the development of mental health among Chinese adolescents. In this two-wave longitudinal research, we tested the mediating...

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