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  • Article
  • Open Access
7 Citations
3,043 Views
9 Pages

Effects of Antithrombotic Treatment on Bleeding Complications of EBUS-TBNA

  • Hyun-Il Gil,
  • Ryoung-Eun Ko,
  • Kyungjong Lee,
  • Sang-Won Um,
  • Hojoong Kim and
  • Byeong-Ho Jeong

5 February 2021

Background and Objectives: The application of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has been markedly increased over the past decade. EBUS-TBNA is known to be a very safe and accurate procedure; however, the inc...

(This article belongs to the Special Issue The Role of Flexible Bronchoscopy in Diagnosing Pulmonary Disease)
  • Article
  • Open Access
5 Citations
6,891 Views
10 Pages

Conventional Transbronchial Needle Aspiration (cTBNA) and EBUS-Guided Transbronchial Needle Aspiration (EBUS-TBNA): A Retrospective Study on the Comparison of the Two Methods for Diagnostic Adequacy in Molecular Analysis

  • Francesca Signorini,
  • Martina Panozzi,
  • Agnese Proietti,
  • Greta Alì,
  • Olivia Fanucchi,
  • Alessandro Picchi,
  • Alessandro Ribechini,
  • Anello M. Poma,
  • Rossella Bruno and
  • Gabriella Fontanini
  • + 1 author

9 October 2021

Introduction: In recent years, there has been a growing development of molecularly targeted therapies for various types of solid tumors—in particular, in non-small-cell lung cancer (NSCLC). This has required the need for greater quantities of tissue...

(This article belongs to the Special Issue Molecular Cytopathology)
  • Article
  • Open Access
12 Citations
1,506 Views
9 Pages

A Randomized Comparison of Sample Adequacy and Diagnostic Yield of Various Suction Pressures in EBUS-TBNA

  • Anant Mohan,
  • Hariharan Iyer,
  • Karan Madan,
  • Vijay Hadd,
  • Saurabh Mitta,
  • Pawan Tiwari,
  • Deepali Jain,
  • Ravindra M. Pandey,
  • Avneet Garg and
  • Randeep Guleria

Introduction: The evidence for using vacuum suction during EBUS is sparse and the optimal suction pressure for obtaining adequate samples has not yet been determined. Our aim was to assess the influence of suction on the adequacy and diagnostic yield...

  • Article
  • Open Access
1 Citations
1,016 Views
15 Pages

Diagnostic Factors Associated with Sarcoidosis in Patients Referred for EBUS-TBNA Due to Mediastinal Lymphadenopathy

  • Paweł Zając,
  • Monika Zając,
  • Wojciech Kądziołka,
  • Andrzej Sokołowski and
  • Ewa Kaznowska

Sarcoidosis is a multisystem granulomatous disease of unknown aetiology that frequently presents with mediastinal lymphadenopathy and often requires invasive diagnostic procedures. Endobronchial ultrasound-guided transbronchial needle aspiration (EBU...

  • Article
  • Open Access
8 Citations
6,077 Views
13 Pages

Safety and Diagnostic Accuracy of the Transnasal Approach for Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA)

  • Roberto Piro,
  • Matteo Fontana,
  • Eleonora Casalini,
  • Laura Rossi,
  • Maria Serena Simeone,
  • Federica Ghinassi,
  • Patrizia Ruggiero,
  • Chiara Pollorsi,
  • Sofia Taddei and
  • Nicola Cosimo Facciolongo
  • + 1 author

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a safe and accurate diagnostic procedure used for investigating mediastinal pathologies. It is usually performed using an oral approach. The nasal route has been proposed...

(This article belongs to the Section Biomedical Optics)
  • Review
  • Open Access
3 Citations
4,926 Views
22 Pages

Infective Complications of Endobronchial Ultrasound-Transbronchial Needle Aspiration (EBUS-TBNA) and Clinical Biomarkers: A Concise Review

  • Pinelopi Bosgana,
  • Dimitrios Ampazis,
  • Vasileios Vlachakos,
  • Argyrios Tzouvelekis and
  • Fotios Sampsonas

EBUS-TBNA is the most common interventional pulmonology procedure performed globally and remains the cornerstone of the diagnosis and staging not only of lung cancer but also for other neoplastic, inflammatory, and infective pathologies of the medias...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
4 Citations
2,498 Views
22 Pages

EBUS-TBNA for Diagnosis and Staging of Lung Cancer: A Retrospective Regional Analysis Integrating Clinical and Molecular Data (EXPoSURE Score)

  • Gabriela Marina Andrei,
  • Natalia Motaș,
  • Virginia Maria Rădulescu,
  • Nina Ionovici,
  • Marius Bunescu,
  • Daniela Luminița Zob,
  • Viorel Biciușcă,
  • Florentina Dumitrescu,
  • Eugenia Andreea Marcu and
  • Mihai Olteanu
  • + 1 author

1 September 2025

Background/Objectives: Lung cancer remains the leading cause of cancer-related mortality worldwide, with a high proportion of cases diagnosed at advanced stages. Accurate mediastinal staging is essential to guide optimal therapeutic decisions. This s...

(This article belongs to the Special Issue Advances in Diagnostic and Surgical Treatment in Lung Cancer and Related Pulmonary Disorders)
  • Review
  • Open Access
656 Views
29 Pages

1 June 2026

Since the discovery of EGFR mutations, treatment strategies have undergone major advances over the past two decades. Accordingly, molecular testing for oncogenic driver mutations is recommended at the time of diagnosis of advanced NSCLC. In addition,...

(This article belongs to the Special Issue Contemporary Lung Cancer Nodal Staging and Evolving Therapeutic Paradigms)
  • Article
  • Open Access
7 Citations
7,998 Views
21 Pages

Evaluation of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA) Samples from Advanced Non-Small Cell Lung Cancer for Whole Genome, Whole Exome and Comprehensive Panel Sequencing

  • David Fielding,
  • Vanessa Lakis,
  • Andrew J. Dalley,
  • Haarika Chittoory,
  • Felicity Newell,
  • Lambros T. Koufariotis,
  • Ann-Marie Patch,
  • Stephen Kazakoff,
  • Farzad Bashirzadeh and
  • Katia Nones
  • + 21 authors

15 February 2024

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is often the only source of tumor tissue from patients with advanced, inoperable lung cancer. EBUS-TBNA aspirates are used for the diagnosis, staging, and genomic testing to...

(This article belongs to the Section Cancer Pathophysiology)
  • Article
  • Open Access
4 Citations
2,893 Views
11 Pages

T Lymphocyte Maturation Profile in the EBUS-TBNA Lymph Node Depending on the DLCO Parameter in Patients with Pulmonary Sarcoidosis

  • Elżbieta Rutkowska,
  • Iwona Kwiecień,
  • Joanna Bednarek,
  • Rafał Sokołowski,
  • Agata Raniszewska,
  • Karina Jahnz- Różyk and
  • Piotr Rzepecki

2 December 2021

Sarcoidosis (SA) is a systemic granulomatous disorder of unknown etiology with lung and mediastinal lymph nodes (LNs) as the main location. T lymphocytes play important role in the formation of granulomas in SA, but still little is known about the ro...

(This article belongs to the Special Issue Sarcoidosis and Granulomatous Diseases: From Molecular and Cellular Mechanisms to Therapeutic Opportunities)
  • Case Report
  • Open Access
4,439 Views
7 Pages

A Case of Mediastinal Tuberculous Lymphadenitis in a Chronic Dialysis Patient Diagnosed by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA)

  • Hiromi Nagashima,
  • Kazuyuki Abe,
  • Yukihiro Owada,
  • Kazuhiro Yakuwa,
  • Hiroshi Katagiri,
  • Shinji Chiba,
  • Ami Matsumoto,
  • Masachika Akiyama,
  • Yu Utsumi and
  • Makoto Maemondo

29 March 2023

A 54-year-old woman on dialysis due to chronic renal failure had a fever lasting 2 weeks and was referred to a hospital. Non-enhanced CT and blood tests showed no remarkable findings. She was hospitalized and received an antibacterial drug. Although...

(This article belongs to the Special Issue Pathogenesis, Diagnostics, and Therapeutics of Infectious Diseases)
  • Article
  • Open Access
291 Views
20 Pages

Beyond the Operating Room? Cytology-Based Yield and Resource Utilization of Outpatient Versus Operating Room EBUS-TBNA Pathways

  • Paolo Albino Ferrari,
  • Cosimo Bruno Salis,
  • Sabrina Sarais,
  • Massimiliano Santoru,
  • Matteo Pinna-Susnik,
  • Sonia Nemolato,
  • Fabiola Farci,
  • Elisabetta Pusceddu,
  • Alessandro Tamburrini and
  • Antonio Macciò
  • + 10 authors

28 August 2026

Background/Objectives: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) can be performed via pathways that differ in anesthesia, setting, airway management, monitoring, recovery, and hospitalization. We compared an outpati...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Letter
  • Open Access
3 Citations
1,074 Views
2 Pages

EBUS-TBNA in Children: The Road Less Travelled

  • Saurabh Mittal,
  • Karan Madan and
  • Anant Mohan

19 April 2021

The ultrasonographic evaluation and sam-pling of mediastinal lesions by endobronchial ul-trasound-guided transbronchial needle aspiration (EBUS-TBNA) or endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the standard of care for adult p...

  • Review
  • Open Access
20 Citations
12,497 Views
15 Pages

Role of EBUS-TBNA in Non-Neoplastic Mediastinal Lymphadenopathy: Review of Literature

  • Valentina Scano,
  • Alessandro Giuseppe Fois,
  • Andrea Manca,
  • Francesca Balata,
  • Angelo Zinellu,
  • Carla Chessa,
  • Pietro Pirina and
  • Panos Paliogiannis

16 February 2022

Mediastinal lymphadenopathy is a condition in which one or more mediastinal lymph nodes are enlarged for malignant or benign causes, generally more than 10 mm. For a long time, the only way to approach the mediastinum was surgery, while in last decad...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
42 Citations
5,552 Views
13 Pages

EBUS-TBNA Cytological Samples for Comprehensive Molecular Testing in Non–Small Cell Lung Cancer

  • Roberto Martin-Deleon,
  • Cristina Teixido,
  • Carmen Mª Lucena,
  • Daniel Martinez,
  • Ainhoa Fontana,
  • Roxana Reyes,
  • Mireia García,
  • Nuria Viñolas,
  • Ivan Vollmer and
  • Noemi Reguart
  • + 7 authors

25 April 2021

Clinical guidelines promote the identification of several targetable biomarkers to drive treatment decisions in advanced non-small cell lung cancer (NSCLC), but half of all patients do not have a viable biopsy. Specimens from endobronchial-ultrasound...

  • Article
  • Open Access
2 Citations
1,819 Views
12 Pages

Refining Lung Cancer Diagnosis and Staging with Bronchoscopy and EBUS-TBNA: Evidence from a Regional Romanian Study

  • Mihai Olteanu,
  • Natalia Motaș,
  • Gabriela Marina Andrei,
  • Virginia Maria Rădulescu,
  • Nina Ionovici,
  • Marius Bunescu,
  • Daniela Luminița Zob,
  • Veronica Manolache,
  • Corina Budin and
  • Ramona Cioboată
  • + 2 authors

26 August 2025

Background: Lung cancer remains the leading cause of cancer-related mortality worldwide. Timely and accurate diagnosis and staging are crucial for treatment decisions. Objective: To assess the feasibility, safety, and diagnostic/staging yield of a br...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
5 Citations
4,080 Views
8 Pages

Diagnostic Accuracy of Slow-Capillary Endobronchial Ultrasound Needle Aspiration in Determining PD-L1 Expression in Non-Small Cell Lung Cancer

  • Lina Zuccatosta,
  • Federico Mei,
  • Michele Sediari,
  • Alessandro Di Marco Berardino,
  • Martina Bonifazi,
  • Francesca Barbisan,
  • Gaia Goteri,
  • Stefano Gasparini and
  • Francesca Gonnelli

12 January 2023

Introduction: The role of EBUS-TBNA in the diagnosis and staging of lung cancer is well established. EBUS-TBNA can be performed using different aspiration techniques. The most common aspiration technique is known as “suction”. One alterna...

  • Article
  • Open Access
6 Citations
1,599 Views
16 Pages

Transbronchial Mediastinal Cryobiopsy Guided by Endobronchial Ultrasound in Addition to Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in the Diagnosis of Ilo-Mediastinal Lymphadenopathy Without Obvious Primary Lung Neoplastic Lesion: A Prospective Multicenter Study

  • Francesco Todisco,
  • Filippo Patrucco,
  • Aleksandar Veljkovic,
  • Gian Carlo Vallese,
  • Davide Indellicati,
  • Letizia Valsecchi,
  • Luca Riberi,
  • Giuseppe Ielo,
  • Paola Rebecca Iovine and
  • Massimo Comune
  • + 2 authors

20 October 2025

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) represents the gold standard technique for the diagnosis and staging of lung carcinoma. However, its diagnostic yield may be limited for granulomatous pathologie...

(This article belongs to the Section Respiratory Medicine)
  • Article
  • Open Access
10 Citations
2,685 Views
11 Pages

Possible Use of Linear Echobronchoscope for Diagnosis of Peripheral Pulmonary Nodules

  • Lina Zuccatosta,
  • Francesca Gonnelli,
  • Gianmarco Gasparini,
  • Arianna Duro,
  • Francesca Barbisan,
  • Gaia Goteri,
  • Giulia Veronesi,
  • Rocco Trisolini and
  • Stefano Gasparini

Echobronchoscope-guided transbronchial needle aspiration (EBUS-TBNA) is mainly used as the transbronchial approach to hilar/mediastinal lymph nodes or lesions, for diagnostic or staging purposes. Moreover, the role of linear EBUS-TBNA as a diagnostic...

(This article belongs to the Special Issue Advances in Cardiovascular and Pulmonary Imaging)
  • Article
  • Open Access
4 Citations
2,864 Views
8 Pages

High SUVmax Is an Independent Predictor of Higher Diagnostic Accuracy of ROSE in EBUS-TBNA for Patients with NSCLC

  • Ying-Yi Chen,
  • Hsin-Ya Huang,
  • Chi-Yi Lin,
  • Kuan-Liang Chen and
  • Tsai-Wang Huang

13 March 2022

Introduction: This study aimed to verify the predictors of the diagnostic accuracy of rapid on-site evaluation (ROSE) in endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) among patients with non-small cell lung cancer (NSCL...

(This article belongs to the Topic eHealth and mHealth: Challenges and Prospects)
  • Feature Paper
  • Article
  • Open Access
8 Citations
2,532 Views
10 Pages

Diagnostic Performance and Cell Count of EBUS–TBNA Needle Gauges: A Prospective Trial

  • Juliana Guarize,
  • Cristina Diotti,
  • Monica Casiraghi,
  • Stefano Donghi,
  • Clementina Di Tonno,
  • Patrizia Mancuso,
  • Laura Zorzino,
  • Giulia Sedda,
  • Davide Radice and
  • Lorenzo Spaggiari
  • + 1 author

13 June 2023

Background. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a well-established diagnostic procedure for evaluating hilar and mediastinal lymphadenopathies and is the gold standard for lung cancer diagnosis and staging....

(This article belongs to the Section Oncology)
  • Article
  • Open Access
1 Citations
1,288 Views
6 Pages

Introduction: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) of mediastinal lymph nodes is currently considered to be the most effective minimally invasive diagnostic method in patients with suspected stage I and II sarc...

  • Article
  • Open Access
29 Citations
3,807 Views
13 Pages

The Impact of Core Tissues on Successful Next-Generation Sequencing Analysis of Specimens Obtained through Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration

  • Keigo Uchimura,
  • Komei Yanase,
  • Tatsuya Imabayashi,
  • Yuki Takeyasu,
  • Hideaki Furuse,
  • Midori Tanaka,
  • Yuji Matsumoto,
  • Shinji Sasada and
  • Takaaki Tsuchida

23 November 2021

The success rate of next-generation sequencing (NGS) with specimens obtained through endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) among patients with lung cancer as well as the related clinical factors remain unclear....

  • Article
  • Open Access
1,392 Views
10 Pages

Additive Value of EBUS-TBNA for Staging Non-Small Cell Lung Cancer in Patients Evaluated for Stereotactic Body Radiation Therapy

  • Joshua M. Boster,
  • S. Michael Goertzen,
  • Paula V. Sainz,
  • Macarena R. Vial,
  • Jhankruti K. Zaveri-Desai,
  • Luis D. Luna,
  • Anum Waqar,
  • Horiana B. Grosu,
  • Roberto F. Casal and
  • Georgie A. Eapen
  • + 5 authors

24 August 2025

Background/Objectives: Patients with non-small cell lung cancer (NSCLC) being evaluated for stereotactic body radiation therapy (SBRT) are frequently staged non-invasively with positron emission tomography/computed tomography (PET/CT). Performing end...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Article
  • Open Access
1 Citations
761 Views
12 Pages

Utility and Safety of Endosonography in the Diagnosis of Small Cell Lung Cancer: A Prospective Single-Center Observational Study

  • Carmine Salerni,
  • Silvia Terraneo,
  • Michele Bonanomi,
  • Sara Mirijaj,
  • Cristina Albrici,
  • Giulia Carone,
  • Letizia Gianoncelli,
  • Mauro Moroni,
  • Umberto Gianelli and
  • Michele Mondoni
  • + 2 authors

Background: Endosonography (i.e., endoscopic ultrasound with bronchoscope fine-needle aspiration, EUS-B-FNA and endobronchial ultrasound-guided transbronchial needle aspiration, EBUS-TBNA) is a widely used technique in the diagnosis and staging of no...

(This article belongs to the Special Issue Recent Advances in the Diagnosis and Prognosis of Lung Cancer)
  • Article
  • Open Access
7 Citations
1,924 Views
6 Pages

Miniforceps EBUS-Guided Lymph Node Biopsy: Impact on Diagnostic Yield

  • Aryan Shiari,
  • Lamia Aljundi,
  • Peter Boshara,
  • Rami K. Zein and
  • Mohammed Zalt

28 February 2021

Introduction: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the standard diagnostic method for sampling mediastinal and hilar lymph nodes. Non-diagnostic samples have led some pulmonologists to add a miniforceps biop...

  • Systematic Review
  • Open Access
8 Citations
2,519 Views
16 Pages

Balancing Accuracy, Safety, and Cost in Mediastinal Diagnostics: A Systematic Review of EBUS and Mediastinoscopy in NSCLC

  • Serban Radu Matache,
  • Ana Adelina Afetelor,
  • Ancuta Mihaela Voinea,
  • George Codrut Cosoveanu,
  • Silviu-Mihail Dumitru,
  • Mihai Alexe,
  • Mihnea Orghidan,
  • Alina Maria Smaranda,
  • Vlad Cristian Dobrea and
  • Cornel Florentin Savu
  • + 2 authors

6 August 2025

Background: Mediastinal staging plays a critical role in guiding treatment decisions for non-small cell lung cancer (NSCLC). While mediastinoscopy has been the gold standard for assessing mediastinal lymph node involvement, endobronchial ultrasound-g...

(This article belongs to the Special Issue Correlations Between Diagnostic Imaging and Morphology in Personalized Medicine)
  • Case Report
  • Open Access
3 Citations
817 Views
2 Pages

One-Shot Diagnosis: Ebus-Tbna as a Single Procedure for Thyroid, Pulmonary and Lymph Nodal Lesions

  • Niccolò Filippi,
  • Elena Prisciandaro,
  • Juliana Guarize,
  • Stefano Maria Donghi,
  • Giulia Sedda and
  • Lorenzo Spaggiari

28 June 2019

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has proved to be the best approach to mediastinal investigation [...]

  • Review
  • Open Access
19 Citations
8,885 Views
15 Pages

Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA): Technical Updates and Pathological Yield

  • Huzaifa A. Jaliawala,
  • Samid M. Farooqui,
  • Kassem Harris,
  • Tony Abdo,
  • Jean I. Keddissi and
  • Houssein A. Youness

10 December 2021

Since the endobronchial ultrasound bronchoscope was introduced to clinical practice, endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has become the procedure of choice to sample hilar and mediastinal adenopathy. Multiple...

(This article belongs to the Special Issue Advances in Interventional Pulmonology)
  • Systematic Review
  • Open Access
1 Citations
809 Views
21 Pages

Comparative Efficacy of Transbronchial Needle Aspiration and Cryobiopsies in Thoracic Disorders: A Systematic Review and Meta-Analysis for Optimal Diagnostic Efficacy

  • Liviu-Ștefan Moacă,
  • Damiana-Maria Vulturar,
  • Daniel-Corneliu Leucuța,
  • Doina Adina Todea,
  • Teodora-Gabriela Alexescu,
  • Maria Adriana Neag,
  • Cezar Aurelian Matau,
  • Anca Dana Buzoianu and
  • Claudia Diana Gherman

3 May 2026

This systematic review and meta-analysis evaluate the comparative diagnostic efficacy and safety of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and transbronchial mediastinal cryobiopsy (EBUS-TBMC) for sampling medias...

(This article belongs to the Special Issue Advances in Pulmonology: Transforming Diagnosis and Treatment of Lung Diseases)
  • Article
  • Open Access
23 Citations
1,209 Views
5 Pages

Initial Polish Experience of Flexible 19 Gauge Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration

  • Maciej Gnass,
  • Joanna Sola,
  • Anna Filarecka,
  • Stanisław Orzechowski,
  • Piotr Kocoń,
  • Monika Pasieka-Lis,
  • Juliusz Pankowski,
  • Lucyna Rudnicka,
  • Jerzy Soja and
  • Artur Szlubowski

Introduction: EBUS is a well established minimally invasive diagnostic tool for mediastinal and hilar lymphadenopathy. The novel ViziShot Flex 19G needle (Olympus Respiratory America, Redmond, WA, USA) was introduced in 2015 in order to improve loade...

  • Article
  • Open Access
21 Citations
3,928 Views
11 Pages

Prediction of Nodal Metastasis in Lung Cancer Using Deep Learning of Endobronchial Ultrasound Images

  • Yuki Ito,
  • Takahiro Nakajima,
  • Terunaga Inage,
  • Takeshi Otsuka,
  • Yuki Sata,
  • Kazuhisa Tanaka,
  • Yuichi Sakairi,
  • Hidemi Suzuki and
  • Ichiro Yoshino

8 July 2022

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a valid modality for nodal lung cancer staging. The sonographic features of EBUS helps determine suspicious lymph nodes (LNs). To facilitate this use of this method, mach...

(This article belongs to the Topic Artificial Intelligence in Cancer Diagnosis and Therapy)
  • Article
  • Open Access
644 Views
14 Pages

Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA) in Moderate Sedation in Patients Aged 80 Years and Older

  • Eleonora Casalini,
  • Matteo Fontana,
  • Roberto Piro,
  • Patrizia Ruggiero,
  • Sofia Taddei,
  • Luca Ronzoni,
  • Laura Rossi and
  • Nicola Facciolongo

25 May 2026

Background/Objectives: The utility and safety of EBUS-TBNA in the general population are well-documented in the scientific literature, but data on elderly patients, particularly those over 80 years old, are limited. Methods: We retrospectively invest...

(This article belongs to the Special Issue Interventional Pulmonology: Advances and Future Directions)
  • Abstract
  • Open Access
758 Views
1 Page

Wstępne polskie doświadczenia z użyciem igły Flex 19G do przezoskrzelowej biopsji pod kontrolą ultrasonografii wewnątrzoskrzelowej

  • Maciej Gnass,
  • Joanna Sola,
  • Anna Filarecka,
  • Stanisław Orzechowski,
  • Piotr Kocoń,
  • Monika Pasieka-Lis,
  • Juliusz Pankowski,
  • Lucyna Rudnicka,
  • Jerzy Soja and
  • Artur Szlubowski

Wstęp: EBUS (endobronchial ultrasonography) jest małoinwazyjną metodą diagnostyczną o dobrze ugruntowanej pozycji w diagnostyce limfadenopatii śródpiersia i wnęk płucnych. ViziShotFlex 19G needle to nowa igła przeznaczona do zastosowania w tym badani...

  • Article
  • Open Access
4 Citations
3,574 Views
13 Pages

Background: The distinction between N2a and N2b in the lung cancer TNM 9th edition staging system has reduced the heterogeneity of prognosis using the previous staging system. Moreover, this distinction may enable new treatment approaches in non-smal...

(This article belongs to the Special Issue Diagnosis, Classification, and Monitoring of Pulmonary Diseases)
  • Review
  • Open Access
8 Citations
7,295 Views
26 Pages

Integrating Artificial Intelligence in Bronchoscopy and Endobronchial Ultrasound (EBUS) for Lung Cancer Diagnosis and Staging: A Comprehensive Review

  • Sebastian Winiarski,
  • Marcin Radziszewski,
  • Maciej Wiśniewski,
  • Jakub Cisek,
  • Dariusz Wąsowski,
  • Dariusz Plewczyński,
  • Katarzyna Górska and
  • Piotr Korczyński

29 August 2025

Artificial intelligence (AI) is increasingly investigated as a potential adjunct in the diagnosis and staging of lung cancer, particularly through integration with bronchoscopy and endobronchial ultrasound (EBUS). Deep learning models have been appli...

(This article belongs to the Special Issue Advancements in Lung Cancer Surgical Treatment and Prognosis)
  • Article
  • Open Access
1 Citations
1,608 Views
11 Pages

14 March 2025

Background: The evolution of interventional pulmonology has necessitated the refinement of anesthetic techniques to ensure the safety and efficacy of procedures such as endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), par...

(This article belongs to the Section Respiratory Medicine)
  • Review
  • Open Access
2 Citations
3,304 Views
12 Pages

Flexible Bronchoscopy and Non-Small-Cell Lung Cancer Staging: A Narrative Review of Modern Techniques for Optimized Clinical Decision-Making

  • Simona-Maria Roșu,
  • Denisa Maria Mitroi,
  • Oana Maria Catană,
  • Viorel Biciușcă,
  • Sorina Ionelia Stan,
  • Beatrice Mahler,
  • Oana-Andreea Parliteanu,
  • Adina Andreea Mirea and
  • Mara Amalia Bălteanu

15 August 2025

Non-small-cell lung cancer (NSCLC) is a widespread and aggressive form of cancer, and in cases of its occurrence, accurate diagnosis and precise staging play a crucial role in determining treatment and estimating prognosis. Flexible bronchoscopy (FB)...

(This article belongs to the Special Issue Moving Forward to New Trends in Pulmonary Diseases)
  • Article
  • Open Access
3 Citations
2,560 Views
10 Pages

20 October 2022

Background: The aim of this study was to verify the importance and the timing of endobronchial ultrasound with transbronchial biopsy (EBUS TBNA) among lung adenocarcinoma patients after radical resection. Methods: We retrospectively reviewed consecut...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
5 Citations
3,133 Views
9 Pages

24 October 2022

Convex probe endobronchial ultrasound transbronchial needle aspirations (CP-EBUS-TBNAs) and radial probe endobronchial ultrasound transbronchial lung biopsies (RP-EBUS-TBLBs) can be performed under moderate sedation or general anesthesia. Moderate se...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Review
  • Open Access
61 Citations
10,794 Views
12 Pages

The role of the respiratory physician in diagnosing lung cancer has increased in complexity over the last 20 years. Adenocarcinoma is now the prevailing histopathological sub-type of non-small cell lung cancer (NSCLC) resulting in more peripheral can...

(This article belongs to the Special Issue Personalized Therapy in Non-Small Cell Lung Cancer: The Role of Biological Agents and Immunotherapy)
  • Article
  • Open Access
5 Citations
2,971 Views
19 Pages

Imbalance of B-Cell Subpopulations in the Microenvironment of Sarcoidosis or Lung Cancer

  • Agata Raniszewska,
  • Iwona Kwiecień,
  • Elżbieta Rutkowska,
  • Joanna Bednarek,
  • Rafał Sokołowski,
  • Piotr Miklusz,
  • Piotr Rzepecki and
  • Karina Jahnz-Różyk

29 July 2024

Although the role of T lymphocytes in sarcoidosis (SA) and lung cancer (LC) is quite well reported, the occurrence of B cells in disease microenvironments may suggest their potential role as natural modifiers of the immune response. The aim of this s...

(This article belongs to the Section Cellular Immunology)
  • Article
  • Open Access
10 Citations
4,264 Views
14 Pages

Immunomodulatory Molecules On Lung Cancer Stem Cells From Lymph Nodes Aspirates

  • Agata Raniszewska,
  • Iwona Kwiecień,
  • Rafał Sokołowski,
  • Elżbieta Rutkowska and
  • Joanna Domagała-Kulawik

31 March 2020

Over the past decade, immune checkpoint inhibitors have revolutionized the treatment of non-small cell lung cancer (NSCLC). Unfortunately, not all patients benefit from PD-(L)1 blockade, yet, the PD-L1 tumor cell expression is the only approved bioma...

(This article belongs to the Special Issue PD-L1/PD1 Modulation Mechanisms in Lung Cancer: From Basic to Translational Evidences)
  • Review
  • Open Access
6 Citations
4,218 Views
26 Pages

Minimally Invasive Sampling of Mediastinal Lesions

  • Alberto Fantin,
  • Nadia Castaldo,
  • Ernesto Crisafulli,
  • Giulia Sartori,
  • Alice Villa,
  • Elide Felici,
  • Stefano Kette,
  • Filippo Patrucco,
  • Erik H. F. M. van der Heijden and
  • Vincenzo Patruno
  • + 2 authors

11 October 2024

This narrative review examines the existing literature on minimally invasive image-guided sampling techniques of mediastinal lesions gathered from international databases (Medline, PubMed, Scopus, and Google Scholar). Original studies, systematic rev...

(This article belongs to the Special Issue Advancements in Surgery: Trends in Prevention, Diagnostic and Treatment)
  • Article
  • Open Access
3 Citations
2,588 Views
13 Pages

Real-Life Comparison of Diagnostic Yield and Sample Adequacy of 22 G and 25 G EBUS-TBNB Needles: A Retrospective Study

  • Filippo Lanfranchi,
  • George Kalak,
  • Gioele Castelli,
  • Laura Mancino,
  • Gabriele Foltran,
  • Alberto Pavan,
  • Lorenzo Ciarrocchi,
  • Licia Laurino and
  • Lucio Michieletto

28 February 2025

Background/Objectives: EBUS-TBNA is a safe and minimally invasive procedure to evaluate hilar and mediastinal lymph nodes (LNs). The Franseen needle provides a transbronchial needle biopsy (TBNB). Various needle sizes are available. In the literature...

(This article belongs to the Special Issue Multidisciplinarity in Thoraco-Pulmonary Diseases: Every Generation Needs a New Revolution. Insights from the XXII SIET National Meeting)
  • Article
  • Open Access
9 Citations
3,716 Views
11 Pages

Clinical Characteristics of and Risk Factors for Fever after Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration: A Retrospective Study Involving 6336 Patients

  • Kyoung Min Moon,
  • Chang-Min Choi,
  • Wonjun Ji,
  • Jae Seung Lee,
  • Sei Won Lee,
  • Kyung-Wook Jo,
  • Jin Woo Song and
  • Jae Cheol Lee

6 January 2020

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive diagnostic for mediastinal and hilar lymphadenopathy/mass. This study investigated fever incidence and associated risk factors after EBUS-TBNA in 633...

(This article belongs to the Section Respiratory Medicine)
  • Article
  • Open Access
15 Citations
3,978 Views
10 Pages

18 April 2018

Background and Objective: Endobronchial ultrasound (EBUS) is a minimally invasive endobronchial technique, which uses ultrasound along with a bronchoscope to visualize the airway wall and structures that are adjacent to it. Indications for endobronch...

  • Article
  • Open Access
12 Citations
3,112 Views
10 Pages

Endobronchial Ultrasound-Guided Transbronchial Forceps Biopsy: A Retrospective Bicentric Study Using the Olympus 1.5 mm Mini-Forceps

  • Fabienne Rüber,
  • Gilles Wiederkehr,
  • Carolin Steinack,
  • Sylvia Höller,
  • Peter Karl Bode,
  • Fabian Kölbener and
  • Daniel Peter Franzen

11 August 2022

When evaluating mediastinal/hilar lymphadenopathy (LAD) or masses, guidelines recommend endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) as an initial technique for tissue analysis and diagnosis. However, owing to the sm...

(This article belongs to the Special Issue The Role of Interventional Pulmonology in Respiratory Diseases: From Diagnosis to Treatment)
  • Review
  • Open Access
7 Citations
4,929 Views
10 Pages

Linear Endobronchial Ultrasound in the Era of Personalized Lung Cancer Diagnostics—A Technical Review

  • Filiz Oezkan,
  • Stephan Eisenmann,
  • Kaid Darwiche,
  • Asmae Gassa,
  • David P. Carbone,
  • Robert E. Merritt and
  • Peter J. Kneuertz

30 November 2021

Major advances in molecular profiling for available targeted treatments and immunotherapy for lung cancer have significantly increased the complexity of tissue-based diagnostics. Endobronchial ultrasound-guided transbronchial needle aspirations (EBUS...

(This article belongs to the Special Issue Interventional Pulmonology: A New World)
  • Article
  • Open Access
506 Views
14 Pages

Cryobiopsy Outperforms Fine-Needle Aspiration for Mediastinal Lymphadenopathy: A Within-Patient Diagnostic Accuracy Study and Clinical Predictors of Success

  • María Hidalgo,
  • Carlos Carpio,
  • Sergio Alcolea,
  • Pablo Mariscal,
  • Maria Alejandra Castillo,
  • Ana Rodriguez,
  • Isabel Esteban,
  • Pilar López and
  • Rodolfo Álvarez-Sala

19 July 2026

Background/Objectives: Accurate diagnosis of lymph node pathology is essential for the management of both malignant and benign diseases. This study compares the diagnostic performance of endobronchial ultrasound-guided transbronchial mediastinal cryo...

(This article belongs to the Special Issue Bronchoscopy and Interventional Pulmonology)

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