Next Article in Journal
Acknowledgment to the Reviewers of Advances in Respiratory Medicine in 2022
Previous Article in Journal
Peritoneal Oxygenation as a Novel Technique for Extrapulmonary Ventilation; A Review and Discussion of the Literature
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
ARM
Volume 91
Issue 1
10.3390/arm91010001
arm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Diagnostic Accuracy of Slow-Capillary Endobronchial Ultrasound Needle Aspiration in Determining PD-L1 Expression in Non-Small Cell Lung Cancer

by
Lina Zuccatosta
1,*,
Federico Mei
1,2,
Michele Sediari
1,
Alessandro Di Marco Berardino
1,
Martina Bonifazi
1,2,
Francesca Barbisan
3,
Gaia Goteri
3,
Stefano Gasparini
1,2 and
Francesca Gonnelli
1
1
Pulmonary Diseases Unit, Azienda Ospedali Riuniti, Via Conca 71, 60126 Ancona, Italy
2
Pulmonary Disease Unit, Dipartimento di Scienze Biomediche e Sanità Pubblica, Polytechnic University of Marche, Via Conca 71, 60126 Ancona, Italy
3
Pathological Anatomy Institute, Polytechnic University of Marche, Via Conca 71, 60126 Ancona, Italy
*
Author to whom correspondence should be addressed.
Adv. Respir. Med. 2023, 91(1), 1-8; https://doi.org/10.3390/arm91010001
Submission received: 3 November 2022 / Revised: 5 January 2023 / Accepted: 9 January 2023 / Published: 12 January 2023
Review Reports Versions Notes

Abstract

Introduction: The role of EBUS-TBNA in the diagnosis and staging of lung cancer is well established. EBUS-TBNA can be performed using different aspiration techniques. The most common aspiration technique is known as “suction”. One alternative to the suction technique is the slow-pull capillary aspiration. To the best of our knowledge, no studies have assessed the diagnostic yield of slow-pull capillary EBUS-TBNA in PD-L1 amplification assessment in NSCLC. Herein, we conducted a single-centre retrospective study to establish the diagnostic yield of slow-pull capillary EBUS-TBNA in terms of PD-L1 in patients with NSCLC and hilar/mediastinal lymphadenopathies subsequent to NSCLC. Materials and Methods: Patients with hilar and/or mediastinal lymph node (LN) NSCLC metastasis, diagnosed by EBUS-TBNA between January 2021 and April 2022 at Pulmonology Unit of “Ospedali Riuniti di Ancona” (Ancona, Italy) were enrolled. We evaluated patient characteristics, including demographic information, CT scan/ FDG-PET features and final histological diagnoses, including PD-L1 assessment. Results: A total of 174 patients underwent EBUS-TBNA for diagnosis of hilar/mediastinal lymphadenopathies between January 2021 and April 2022 in the Interventional Pulmonology Unit of the “Ospedali Riuniti di Ancona”. Slow-pull capillary aspiration was adopted in 60 patients (34.5%), and in 30/60 patients (50.0%) NSCLC was diagnosed. EBUS-TBNA with slow-pull capillary aspiration provided adequate sampling for molecular biology and PD-L1 testing in 96.7% of patients (29/30); in 15/29 (51.7%) samples with more than 1000 viable cells/HPF were identified, whereas in 14/29 (48.3%) samples contained 101–1000 viable cells/HPF. Conclusion: These retrospective study shows that slow-pull capillary aspiration carries an excellent diagnostic accuracy, almost equal to that one reported in literature, supporting its use in EBUS-TBNA for PD-L1 testing in NSCLC.
Keywords: EBUS-TBNA; PD-L1; NSCLC; lung cancer; lymph nodes EBUS-TBNA; PD-L1; NSCLC; lung cancer; lymph nodes

Share and Cite

MDPI and ACS Style

Zuccatosta, L.; Mei, F.; Sediari, M.; Di Marco Berardino, A.; Bonifazi, M.; Barbisan, F.; Goteri, G.; Gasparini, S.; Gonnelli, F. Diagnostic Accuracy of Slow-Capillary Endobronchial Ultrasound Needle Aspiration in Determining PD-L1 Expression in Non-Small Cell Lung Cancer. Adv. Respir. Med. 2023, 91, 1-8. https://doi.org/10.3390/arm91010001

AMA Style

Zuccatosta L, Mei F, Sediari M, Di Marco Berardino A, Bonifazi M, Barbisan F, Goteri G, Gasparini S, Gonnelli F. Diagnostic Accuracy of Slow-Capillary Endobronchial Ultrasound Needle Aspiration in Determining PD-L1 Expression in Non-Small Cell Lung Cancer. Advances in Respiratory Medicine. 2023; 91(1):1-8. https://doi.org/10.3390/arm91010001

Chicago/Turabian Style

Zuccatosta, Lina, Federico Mei, Michele Sediari, Alessandro Di Marco Berardino, Martina Bonifazi, Francesca Barbisan, Gaia Goteri, Stefano Gasparini, and Francesca Gonnelli. 2023. "Diagnostic Accuracy of Slow-Capillary Endobronchial Ultrasound Needle Aspiration in Determining PD-L1 Expression in Non-Small Cell Lung Cancer" Advances in Respiratory Medicine 91, no. 1: 1-8. https://doi.org/10.3390/arm91010001

APA Style

Zuccatosta, L., Mei, F., Sediari, M., Di Marco Berardino, A., Bonifazi, M., Barbisan, F., Goteri, G., Gasparini, S., & Gonnelli, F. (2023). Diagnostic Accuracy of Slow-Capillary Endobronchial Ultrasound Needle Aspiration in Determining PD-L1 Expression in Non-Small Cell Lung Cancer. Advances in Respiratory Medicine, 91(1), 1-8. https://doi.org/10.3390/arm91010001

Article Metrics

Back to TopTop