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Clinical Characteristics of and Risk Factors for Fever after Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration: A Retrospective Study Involving 6336 Patients

1
Department of Pulmonary, Allergy, and Critical Care Medicine, Gangneung Asan Hospital, College of Medicine, University of Ulsan, Gangneung 44608, Korea
2
Department of Pulmonary, and Critical Care Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul 100744, Korea
3
Department of Oncology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul 100744, Korea
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(1), 152; https://doi.org/10.3390/jcm9010152 (registering DOI)
Received: 15 November 2019 / Revised: 31 December 2019 / Accepted: 3 January 2020 / Published: 6 January 2020
(This article belongs to the Section Pulmonology)
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive diagnostic for mediastinal and hilar lymphadenopathy/mass. This study investigated fever incidence and associated risk factors after EBUS-TBNA in 6336 patients who underwent EBUS-TBNA at Asan Medical Center from October 2008 to February 2018. Bronchoscopists evaluated participants’ medical records for fever the 24 h following EBUS-TBNA. Patients were placed in either a Fever group (n = 665) or a non-Fever group (n = 5671). Fever developed in 665 of 6336 patients (10.5%) with a mean peak body temperature of 38.3 °C (range, 37.8–40.6 °C). Multivariate analysis revealed that fever-associated risk factors after EBUS-TBNA are older age (adjusted OR 0.015, 95% CI (0.969–0.997), p = 0.015), bronchoscopic washing (adjusted OR 1.624, 95% CI (1.114–2.368), p = 0.012), more than four samples of EBUS-TBNA (adjusted OR 2.472, 95% CI (1.288–4.745), p = 0.007), hemoglobin levels before EBUS-TBNA (adjusted OR 0.876, 95% CI (0.822–0.933), p < 0.001), CRP levels before EBUS-TBNA (adjusted OR 1.115, 95% CI (1.075–1.157), p < 0.001), and a diagnosis of EBUS-TBNA tuberculosis (adjusted OR 3.409, 95% CI (1.870–6.217), p < 0.001). Clinicians should be aware of the possibility of fever after EBUS-TBNA because it is common. Additional, prospective, large-scale research should assess the need for prophylactic antibiotics for EBUS-TBNA. View Full-Text
Keywords: endobronchial ultrasound-guided transbronchial needle aspiration; fever; incidence; risk factor endobronchial ultrasound-guided transbronchial needle aspiration; fever; incidence; risk factor
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Moon, K.M.; Choi, C.-M.; Ji, W.; Lee, J.S.; Lee, S.W.; Jo, K.-W.; Song, J.W.; Lee, J.C. Clinical Characteristics of and Risk Factors for Fever after Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration: A Retrospective Study Involving 6336 Patients. J. Clin. Med. 2020, 9, 152.

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