Recent Advances in the Diagnosis and Prognosis of Lung Cancer

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 10 December 2025 | Viewed by 895

Special Issue Editor


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Guest Editor
School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
Interests: lung cancer

Special Issue Information

Dear Colleagues,

Lung cancer persists as one of the most widespread and lethal malignancies globally, driving the urgent need for innovative diagnostic and prognostic strategies to improve survival and patient outcomes. This Special Issue spotlights cutting-edge research and technological advancements reshaping the field, with a dual emphasis on precision detection and personalized prognostication.

At the forefront of diagnosis, emerging imaging modalities, molecular biomarker discovery, and genomic profiling are revolutionizing early detection and diagnostic accuracy. These tools address critical challenges such as tumor heterogeneity and late-stage presentation, offering hope for timely intervention. Complementing these advances, artificial intelligence (AI)-driven predictive models and genomic signatures are redefining prognostic paradigms, enabling clinicians to stratify risk, predict therapeutic response, and tailor management plans to individual patients. By synthesizing contributions from leading researchers and clinicians, this issue provides a comprehensive examination of both current innovations and future trajectories in lung cancer care.

Prof. Dr. Naomi Takemura
Guest Editor

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Keywords

  • lung cancer
  • molecular biomarkers
  • artificial intelligence
  • early detection
  • precision detection
  • medical imaging

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Published Papers (1 paper)

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Review

12 pages, 1062 KB  
Review
Current Surgical Perspective on the Prognosis of Small-Cell Lung Cancer
by Hüseyin Fatih Sezer
Diagnostics 2025, 15(21), 2704; https://doi.org/10.3390/diagnostics15212704 - 25 Oct 2025
Viewed by 714
Abstract
Small-cell lung cancer (SCLC) is a highly aggressive neuroendocrine tumour that can metastasise early, may show resistance to systemic treatment, and has a poor prognosis. The use of tobacco products is closely related to the duration of their use, and approximately 95% of [...] Read more.
Small-cell lung cancer (SCLC) is a highly aggressive neuroendocrine tumour that can metastasise early, may show resistance to systemic treatment, and has a poor prognosis. The use of tobacco products is closely related to the duration of their use, and approximately 95% of those diagnosed have a history of smoking. No satisfactory progress has been made in the prognosis with current treatment methods up to the present day. The treatment approach has traditionally involved long-term chemotherapy (CT) and radiotherapy (RT), and recent literature has focused on immunotherapy and genetic advancements. Surgery can only be performed in cases detected at an early stage. Although both chemotherapy and radiotherapy are indispensable options for most patients, their impact on prognosis and survival is limited. Although promising developments are expected in immunotherapy, its impact on survival is still very limited, lasting only about 2 months. In patients undergoing surgical resection as part of their treatment, overall survival (OS) ranges from 34 to 69 months. OS for 1 year is 84.8–93.8%, for 3 years is 60–71.2%, and for 5 years is 51.1–63.8%. The five-year survival rates are reported as follows: stage I 31–63.8%, stage II 25–65.5%, stage III 15–27.8%, and stage IV 0%. In this study, the prognosis and factors affecting prognosis in SCLC were investigated in light of current literature from a surgical perspective, and predictions were attempted to be made to lay the groundwork for personalised treatment approaches. Compared to non-small-cell lung cancer, the number of studies is quite limited. Most of the surgical case series were conducted in the past, retrospectively, and involved a small number of patients. Advances in immunotherapy are promising. In the early stages, resection and subsequent chemotherapy may be the main treatment. Full article
(This article belongs to the Special Issue Recent Advances in the Diagnosis and Prognosis of Lung Cancer)
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