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Healthcare
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Correlations Between Diagnostic Imaging and Morphology in Personalized Medicine
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Correlations Between Diagnostic Imaging and Morphology in Personalized Medicine

A special issue of Healthcare (ISSN 2227-9032).

Deadline for manuscript submissions: 31 January 2026 | Viewed by 692

Special Issue Editors

Dr. Adrian Costache

E-Mail Website
Guest Editor
Pathology Department, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
Interests: pathology; ultrasound; imaging; oncology; artificial intelligence; personalized medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Mihai Dumitru

E-Mail Website
Guest Editor
ENT Department, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
Interests: imaging; otorhinolaryngology; surgery; ultrasound; oncology; personalized medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit a manuscript to this Special Issue, entitled “Correlations Between Diagnostic Imaging and Morphology in Personalized Medicine”. This Special Issue aims to highlight the importance of diagnostic imaging modalities such as computer tomography (CT), ultrasonography (US), magnetic resonance imaging (MRI) or positron emission tomography (PET) in managing complex cases of personalized medicine. The imaging findings must be correlated with the final pathology result, and thus there should be a strong collaboration between the clinician, pathologist and imaging specialist. This Special Issue welcomes the submission of original research articles, reviews and complex case reports whose scope includes, but is not limited to, the following topics: surgery, otorhinolaryngology, orthopedics, ophthalmology, dermatology, and urology.

Dr. Adrian Costache
Dr. Mihai Dumitru
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Healthcare is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • imaging
  • tomography
  • ultrasonography
  • personalized medicine
  • pathology
  • oncology
  • otorhinolaryngology
  • surgery
  • dermatology
  • artificial intelligence

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Published Papers (1 paper)

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16 pages, 752 KB  
Systematic Review
Balancing Accuracy, Safety, and Cost in Mediastinal Diagnostics: A Systematic Review of EBUS and Mediastinoscopy in NSCLC
by Serban Radu Matache, Ana Adelina Afetelor, Ancuta Mihaela Voinea, George Codrut Cosoveanu, Silviu-Mihail Dumitru, Mihai Alexe, Mihnea Orghidan, Alina Maria Smaranda, Vlad Cristian Dobrea, Alexandru Șerbănoiu, Beatrice Mahler and Cornel Florentin Savu
Healthcare 2025, 13(15), 1924; https://doi.org/10.3390/healthcare13151924 - 6 Aug 2025
Viewed by 458
Abstract
Background: Mediastinal staging plays a critical role in guiding treatment decisions for non-small cell lung cancer (NSCLC). While mediastinoscopy has been the gold standard for assessing mediastinal lymph node involvement, endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has emerged as a minimally invasive alternative [...] Read more.
Background: Mediastinal staging plays a critical role in guiding treatment decisions for non-small cell lung cancer (NSCLC). While mediastinoscopy has been the gold standard for assessing mediastinal lymph node involvement, endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has emerged as a minimally invasive alternative with comparable diagnostic accuracy. This systematic review evaluates the diagnostic performance, safety, cost-effectiveness, and feasibility of EBUS-TBNA versus mediastinoscopy for mediastinal staging. Methods: A systematic literature review was conducted in accordance with PRISMA guidelines, including searches in Medline, Scopus, EMBASE, and Cochrane databases for studies published from 2010 onwards. A total of 1542 studies were identified, and after removing duplicates and applying eligibility criteria, 100 studies were included for detailed analysis. The extracted data focused on sensitivity, specificity, complications, economic impact, and patient outcomes. Results: EBUS-TBNA demonstrated high sensitivity (85–94%) and specificity (~100%), making it an effective first-line modality for NSCLC staging. Mediastinoscopy remained highly specific (~100%) but exhibited slightly lower sensitivity (86–90%). EBUS-TBNA had a lower complication rate (~2%) and was more cost-effective, while mediastinoscopy provided larger biopsy samples, essential for molecular and histological analyses. The need for general anaesthesia, longer hospital stays, and increased procedural costs make mediastinoscopy less favourable as an initial approach. Combining both techniques in select cases enhanced overall staging accuracy, reducing false negatives and improving diagnostic confidence. Conclusions: EBUS-TBNA has become the preferred first-line mediastinal staging method due to its minimally invasive approach, high diagnostic accuracy, and lower cost. However, mediastinoscopy remains crucial in cases requiring posterior mediastinal node assessment or larger tissue samples. The integration of both techniques in a stepwise diagnostic strategy offers the highest accuracy while minimizing risks and costs. Given the lower hospitalization rates and economic benefits associated with EBUS-TBNA, its widespread adoption may contribute to more efficient resource utilization in healthcare systems. Full article
(This article belongs to the Special Issue Correlations Between Diagnostic Imaging and Morphology in Personalized Medicine)
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