Molecular Cytopathology

Dear Colleagues,

Cytopathology is undergoing a change. Beyond being a cost-effective screening tool for more invasive histopathological evaluations, in many settings cytopathology is a complete, independent and reliable diagnostic procedure. Molecular techniques can be nicely applied to cytological samples by taking into account specific pre-analytical issues due to a variety of many different preparations that make it difficult to ensure standardization and reproducibility. In particular, nucleic acids are of generally good quality, even when obtained from routine stained archival smears. Modern cytopathology also provides biomarker assessments to refine uncertain morphology and to yield prognostic and predictive assessments, and is a valuable tool to monitor sub-clonal tumor evolution and cancer heterogeneity, particularly in assessing resistant mechanisms to escape from targeted therapy regimens. Next generation sequencing is a modern variation of molecular cytopathology and complements morphology with a minimally invasive approach. In this Special Issue we aim to provide an update on the most recent developments in the field of molecular cytopathology, focusing on the main information that can be provided for the multidisciplinary management of solid tumors.

Prof. Dr. Giancarlo Troncone
Prof. Philippe Vielh
Dr. Pasquale Pisapia
Guest Editors

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