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Advances in Diagnostic and Surgical Treatment in Lung Cancer and Related Pulmonary Disorders

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Respiratory Medicine".

Deadline for manuscript submissions: 17 December 2025 | Viewed by 748

Special Issue Editors


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Guest Editor
1. Department of Thoracic Surgery, Institute of Oncology Bucharest, Bucharest, Romania
2. Clinic of Thoracic Surgery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
3. Department of Thoracic Surgery, Memorial Hospital, Bucharest, Romania
Interests: lung cancer; minimally invasive thoracic surgery; AI; airway interventional procedures

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Guest Editor Assistant
1. Department of Thoracic Surgery, Memorial Hospital, Bucharest, Romania
2. Clinic of Thoracic Surgery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Interests: lung cancer; minimally invasive thoracic surgery; AI; air-way interventional procedures

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the evolving role of diagnostics and surgery in the care of patients with lung cancer and complex pulmonary diseases. In an era of rapid technological advancement, the human element of medicine—timely diagnosis, thoughtful decision making, skilled surgical care and personalized multimodal management—remains at the heart of patient outcomes.

We welcome clinical research and review articles (but not exclusively) that explore the following topics:

  • Practical innovations in imaging and early diagnosis;
  • Minimally invasive and robotic-assisted surgeries that reduce patient burden;
  • Perioperative care and enhanced recovery after surgery (ERAS) protocols;
  • Multidisciplinary treatment pathways;
  • Personalized treatment planning based on diagnostic insights;
  • Combination therapies involving surgery, radiotherapy, chemotherapy, and immunotherapy;
  • Patient-centered management of adverse effects and complications;
  • Challenges in treating advanced or inoperable cases;
  • Surgical treatment of infections, malformations, and inflammatory lung diseases;
  • Patient-centered outcomes, recovery, and quality of life.

This Special Issue aims to bridge high-tech progress with a hands-on clinical impact, showcasing how modern (but also basic) diagnostic and surgical tools are improving not just survival but also the experience and dignity of care.

Dr. Natalia Motas
Guest Editor

Dr. Veronica Manolache
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lung cancer
  • minimally invasive thoracic surgery (MITS)
  • video-assisted thoracoscopic surgery (VATS)
  • robot-assisted thoracic surgery (RATS)
  • interventional pneumology
  • bronchoscopy
  • endobronchial ultrasound (EBUS)
  • artificial intelligence (AI)
  • lung nodule

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Published Papers (1 paper)

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Research

22 pages, 863 KB  
Article
EBUS-TBNA for Diagnosis and Staging of Lung Cancer: A Retrospective Regional Analysis Integrating Clinical and Molecular Data (EXPoSURE Score)
by Gabriela Marina Andrei, Natalia Motaș, Virginia Maria Rădulescu, Nina Ionovici, Marius Bunescu, Daniela Luminița Zob, Viorel Biciușcă, Florentina Dumitrescu, Eugenia Andreea Marcu, Ramona Cioboată and Mihai Olteanu
J. Clin. Med. 2025, 14(17), 6179; https://doi.org/10.3390/jcm14176179 - 1 Sep 2025
Viewed by 526
Abstract
Background/Objectives: Lung cancer remains the leading cause of cancer-related mortality worldwide, with a high proportion of cases diagnosed at advanced stages. Accurate mediastinal staging is essential to guide optimal therapeutic decisions. This study aimed to evaluate the diagnostic performance of endobronchial ultrasound-guided [...] Read more.
Background/Objectives: Lung cancer remains the leading cause of cancer-related mortality worldwide, with a high proportion of cases diagnosed at advanced stages. Accurate mediastinal staging is essential to guide optimal therapeutic decisions. This study aimed to evaluate the diagnostic performance of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and to develop a composite clinical–molecular score (EXPoSURE) for risk stratification. Methods: A retrospective study was performed that included 131 patients diagnosed with lung cancer between December 2023 and December 2024 at a regional oncology center in Oltenia, Romania. All patients underwent bronchoscopy and EBUS-TBNA using a standardized protocol. Clinical, pathological, and molecular data were collected to assess diagnostic yield, staging performance, and the association with molecular markers. The EXPoSURE score integrated PD-L1, p63, EGFR status, comorbidities, histological type, and TNM stage. Results: EBUS-TBNA provided a conclusive diagnosis in 91.6% of cases, with a low rebiopsy rate of 8.4% and no requirement for mediastinoscopy. Most patients (68%) were diagnosed at stage IV. PD-L1, p63, and EGFR expression showed no significant correlation with TNM stage, while the EXPoSURE score demonstrated promising stratification capability. Occupational exposure appeared to influence disease severity in some subgroups, although further validation is needed. Conclusions: EBUS-TBNA is a valuable, safe, and effective approach for minimally invasive diagnosis and mediastinal staging of lung cancer. The proposed EXPoSURE composite score may contribute to a multidimensional risk assessment, supporting more tailored management strategies and warranting prospective validation. Full article
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