MDPI’s Best Paper Awards in Biology and Life Sciences—Winners Announced in 2022

The purpose of our Best Paper Awards is to promote and recognize the most impactful contributions published within MDPI journals.

The editors of each journal carefully selected reviews and research papers through a rigorous judging process based on criteria such as scientific merit, overall impact, and the quality of presentation.

We are honored to present the winners for the year 2022 in biology and life sciences, who were selected amongst extensive competition, and congratulate the authors for their outstanding scientific publications. MDPI will continue to provide support and recognition to the academic community.

Agronomy:

• “From Smart Farming towards Agriculture 5.0: A Review on Crop Data Management”
  by Verónica Saiz-Rubio and Francisco Rovira-Más
  Agronomy 2020, 10(2), 207; https://doi.org/10.3390/agronomy10020207

• “Comparison of Biochemical, Anatomical, Morphological, and Physiological Responses to Salinity Stress in Wheat and Barley Genotypes Deferring in Salinity Tolerance”
  by Muhammad Zeeshan, Meiqin Lu, Shafaque Sehar, Paul Holford and Feibo Wu
  Agronomy 2020, 10(1), 127; https://doi.org/10.3390/agronomy10010127

• “The Use of a Plant-Based Biostimulant Improves Plant Performances and Fruit Quality in Tomato Plants Grown at Elevated Temperatures”
  by Silvana Francesca Carmen Arena, Bruno Hay Mele, Carlo Schettini, Patrizia Ambrosino, Amalia Barone and Maria Manuela Rigano
  Agronomy 2020, 10(3), https://doi.org/10.3390/agronomy10030363

• “The Management of Agricultural Waste Biomass in the Framework of Circular Economy and Bioeconomy: An Opportunity for Greenhouse Agriculture in Southeast Spain”
  by Mónica Duque-Acevedo, Luis J. Belmonte-Ureña, José A. Plaza-Úbeda and Francisco Camacho-Ferre
  Agronomy 2020, 10(4), 489; https://doi.org/10.3390/agronomy10040489

Biology:

• “Apoptotic Bodies: Particular Extracellular Vesicles Involved in Intercellular Communication”
  by Michela Battistelli and Elisabetta Falcieri
  Biology 2020, 9(1), 21; https://doi.org/10.3390/biology9010021

• “Vegetation and Environmental Changes on Non-Reclaimed Spoil Heaps in Southern Poland”
  by Oimahmad Rahmonov, Robert Krzysztofik, Dorota Środek and Justyna Smolarek-Lach
  Biology 2020, 9(7), 164; https://doi.org/10.3390/biology9070164

• “Formyl Peptide Receptor 1 Signaling in Acute Inflammation and Neural Differentiation Induced by Traumatic Brain Injury”
  by Roberta Fusco, Enrico Gugliandolo, Rosalba Siracusa, Maria Scuto, Marika Cordaro, Ramona D’Amico, Maurizio Evangelista, Angelo Peli, Alessio Filippo Peritore, Daniela Impellizzeri et al.
  Biology 2020, 9(9), 238; https://doi.org/10.3390/biology9090238

Brain Sciences:

• “Cholesterol and Alzheimer’s Disease Risk: A Meta-Meta-Analysis”
  by Olalla Sáiz-Vazquez, Alicia Puente-Martínez, Silvia Ubillos-Landa, Joaquín Pacheco-Bonrostro and Javier Santabárbara
  Brain Sci. 2020, 10(6), 386; https://doi.org/10.3390/brainsci10060386

• “Psychosocial and Behavioral Impact of COVID-19 in Autism Spectrum Disorder: An Online Parent Survey”
  by Marco Colizzi, Elena Sironi, Federico Antonini, Marco Luigi Ciceri, Chiara Bovo and Leonardo Zoccante
  Brain Sci. 2020, 10(6), 341; https://doi.org/10.3390/brainsci10060341

Diversity:

• “More Than a Functional Group: Diversity within the Legume–Rhizobia Mutualism and Its Relationship with Ecosystem Function”
  by Benton N. Taylor, Ellen L. Simms and Kimberly J. Komatsu
  Diversity 2020, 12(2), 50; https://doi.org/10.3390/d12020050

• “A Common Approach to the Conservation of Threatened Island Vascular Plants: First Results in the Mediterranean Basin”
  by Giuseppe Fenu, Gianluigi Bacchetta, Charalambos S. Christodoulou, Donatella Cogoni, Christini Fournaraki, Giusso del Galdo Gian Pietro, Panagiota Gotsiou, Angelos Kyratzis, Carole Piazza, Magdalena Vicens et al.
  Diversity 2020, 12(4), 157; https://doi.org/10.3390/d12040157

• “Plant Diversity Patterns and Conservation Implications under Climate-Change Scenarios in the Mediterranean: The Case of Crete (Aegean, Greece)”
  by Konstantinos Kougioumoutzis, Ioannis P. Kokkoris, Maria Panitsa, Panayiotis Trigas, Arne Strid and Panayotis Dimopoulos
  Diversity 2020, 12(7), 270; https://doi.org/10.3390/d12070270

• “Conserving the Diversity of Ecological Interactions: The Role of Two Threatened Macaw Species as Legitimate Dispersers of ‘Megafaunal’ Fruits”
  by José L. Tella, Fernando Hiraldo, Erica Pacífico, José A. Díaz-Luque, Francisco V. Dénes, Fernanda M. Fontoura, Neiva Guedes and Guillermo Blanco
  Diversity 2020, 12(2), 45; https://doi.org/10.3390/d12020045

Genes:    

• “Genomics in Bacterial Taxonomy: Impact on the Genus Pseudomonas”
  by Jorge Lalucat, Magdalena Mulet, Margarita Gomila and Elena García-Valdés
  Genes 2020, 11(2), 139; https://doi.org/10.3390/genes11020139

• “Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability”
  by Giorgio Milazzo, Daniele Mercatelli, Giulia Di Muzio, Luca Triboli, Piergiuseppe De Rosa, Giovanni Perini and Federico M. Giorgi
  Genes 2020, 11(5), 556; https://doi.org/10.3390/genes11050556

• “COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells”
  by Andrea Latini, Emanuele Agolini, Antonio Novelli, Paola Borgiani, Rosalinda Giannini, Paolo Gravina, Andrea Smarrazzo, Mario Dauri, Massimo Andreoni, Paola Rogliani et al.
  Genes 2020, 11(9), 1010; https://doi.org/10.3390/genes11091010

• “Clustered DNA Double-Strand Breaks: Biological Effects and Relevance to Cancer Radiotherapy”
  by Jac A. Nickoloff, Neelam Sharma and Lynn Taylor
  Genes 2020, 11(1), 99; https://doi.org/10.3390/genes11010099

• “Inhibition of Angiotensin-Converting Enzyme Ameliorates Renal Fibrosis by Mitigating DPP-4 Level and Restoring Antifibrotic MicroRNAs”
  by Swayam Prakash Srivastava, Julie E. Goodwin, Keizo Kanasaki and Daisuke Koya
  Genes 2020, 11(2), 211; https://doi.org/10.3390/genes11020211

• “Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae”
  by Tania Jordá and Sergi Puig
  Genes 2020, 11(7), 795; https://doi.org/10.3390/genes11070795

IJMS:     

• “Laccase Properties, Physiological Functions, and Evolution”
  by Grzegorz Janusz, Anna Pawlik, Urszula Świderska-Burek, Jolanta Polak, Justyna Sulej, Anna Jarosz-Wilkołazka and Andrzej Paszczyński
  Int. J. Mol. Sci. 2020, 21(3), 966; https://doi.org/10.3390/ijms21030966

• “Lysosomal Exocytosis, Exosome Release and Secretory Autophagy: The Autophagic- and Endo-Lysosomal Systems Go Extracellular”
  by Sandra Buratta, Brunella Tancini, Krizia Sagini, Federica Delo, Elisabetta Chiaradia, Lorena Urbanelli and Carla Emiliani
  Int. J. Mol. Sci. 2020, 21(7), 2576; https://doi.org/10.3390/ijms21072576

• “Recent Advances in Lipopolysaccharide Recognition Systems”
  by Lalita Mazgaeen and Prajwal Gurung
  Int. J. Mol. Sci. 2020, 21(2), 379; https://doi.org/10.3390/ijms21020379

• “Redox Interactions of Vitamin C and Iron: Inhibition of the Pro-Oxidant Activity by Deferiprone”
  by Viktor A. Timoshnikov, Tatyana V. Kobzeva, Nikolay E. Polyakov and George J. Kontoghiorghes
  Int. J. Mol. Sci. 2020, 21(11), 3967; https://doi.org/10.3390/ijms21113967

• “Modulation of Pro-Oxidant and Pro-Inflammatory Activities of M1 Macrophages by the Natural Dipeptide Carnosine”
  by Claudia G. Fresta, Annamaria Fidilio, Giacomo Lazzarino, Nicolò Musso, Margherita Grasso, Sara Merlo, Angela M. Amorini, Claudio Bucolo, Barbara Tavazzi, Giuseppe Lazzarino et al.
  Int. J. Mol. Sci. 2020, 21(3), 776; https://doi.org/10.3390/ijms21030776

• “SAAMBE-3D: Predicting Effect of Mutations on Protein–Protein Interactions”
  by Swagata Pahari, Gen Li, Adithya Krishna Murthy, Siqi Liang, Robert Fragoza, Haiyuan Yu and Emil Alexov
  Int. J. Mol. Sci. 2020, 21(7), 2563; https://doi.org/10.3390/ijms21072563

Insects:  

• “Diversity and Global Distribution of Viruses of the Western Honey Bee, Apis mellifera”
  by Alexis Beaurepaire, Niels Piot, Vincent Doublet, Karina Antunez, Ewan Campbell, Panuwan Chantawannakul, Nor Chejanovsky, Anna Gajda, Matthew Heerman and Delphine Panziera
  Insects 2020, 11(4), 239; https://doi.org/10.3390/insects11040239

• “Soil Health and Arthropods: From Complex System to Worthwhile Investigation”
  by Cristina Menta and Sara Remelli
  Insects 2020, 11(1), 54; https://doi.org/10.3390/insects11010054

• “Influence of Temperature on Age-Stage, Two-Sex Life Tables for a Minnesota-Acclimated Population of the Brown Marmorated Stink Bug (Halyomorpha halys)”
  by Byju N. Govindan and William D. Hutchison
  Insects 2020, 11(2), 108; https://doi.org/10.3390/insects11020108

Life:

• “Characterization of Resistance in Gram-Negative Urinary Isolates Using Existing and Novel Indicators of Clinical Relevance: A 10-Year Data Analysis”
  by Márió Gajdács, Zoltán Bátori, Marianna Ábrók, Andrea Lázár and Katalin Burián
  Life 2020, 10(2), 16; https://doi.org/10.3390/life10020016

• “Neuroprotection or Neurotoxicity of Illicit Drugs on Parkinson’s Disease”
  by Carla Ferreira, Catarina Almeida, Sandra Tenreiro and Alexandre Quintas
  Life 2020, 10(6), 86; https://doi.org/10.3390/life10060086

Metabolites:          

• “Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment”
  by Andrea Angeli, Fabrizio Carta, Alessio Nocentini, Jean-Yves Winum, Raivis Zalubovskis, Atilla Akdemir, Valentina Onnis, Wagdy M. Eldehna, Clemente Capasso, Giuseppina De Simone et al.
  Metabolites 2020, 10(10), 412; https://doi.org/10.3390/metabo10100412

• “MetaboAnalystR 3.0: Toward an Optimized Workflow for Global Metabolomics”
  by Zhiqiang Pang, Jasmine Chong, Shuzhao Li and Jianguo Xia
  Metabolites 2020, 10(5), 186; https://doi.org/10.3390/metabo10050186

• “Tryptophan Metabolism, Inflammation, and Oxidative Stress in Patients with Neurovascular Disease”
  by Martin Hajsl, Alzbeta Hlavackova, Karolina Broulikova, Martin Sramek, Martin Maly, Jan E. Dyr and Jiri Suttnar
  Metabolites 2020, 10(5), 208; https://doi.org/10.3390/metabo10050208

MPs:

• “Production and Purification of Artificial Circular RNA Sponges for Application in Molecular Biology and Medicine”
  by Janina Breuer and Oliver Rossbach
  Methods Protoc. 2020, 3(2), 42; https://doi.org/10.3390/mps3020042

Pathogens:

• “Effectiveness of Chemical Compounds Used against African Swine Fever Virus in Commercial Available Disinfectants”
  by Małgorzata Juszkiewicz, Marek Walczak, Natalia Mazur-Panasiuk and Grzegorz Woźniakowski
  Pathogens 2020, 9(11), 878; https://doi.org/10.3390/pathogens9110878

• “Betanodavirus and VER Disease: A 30-year Research Review”
  by Isabel Bandín and Sandra Souto
  Pathogens 2020, 9(2), 106; https://doi.org/10.3390/pathogens9020106

• “The Bradyzoite: A Key Developmental Stage for the Persistence and Pathogenesis of Toxoplasmosis”
  by Aude Cerutti, Nicolas Blanchard and Sébastien Besteiro
  Pathogens 2020, 9(3), 234; https://doi.org/10.3390/pathogens9030234

• “Understanding Flavivirus Capsid Protein Functions: The Tip of the Iceberg”
  by Stephanea Sotcheff and Andrew Routh
  Pathogens 2020, 9(1), 42; https://doi.org/10.3390/pathogens9010042

Plants:

• “Photosynthetic Metabolism under Stressful Growth Conditions as a Bases for Crop Breeding and Yield Improvement”
  by Fermín Morales, María Ancín, Dorra Fakhet, Jon González-Torralba, Angie L. Gámez, Amaia Seminario, David Soba, Sinda Ben Mariem, Miguel Garriga and Iker Aranjuelo
  Plants 2020, 9(1), 88; https://doi.org/10.3390/plants9010088

• “Plant Roots Release Small Extracellular Vesicles with Antifungal Activity”
  by Monica De Palma, Alfredo Ambrosone, Antonietta Leone, Pasquale Del Gaudio, Michelina Ruocco, Lilla Turiák, Ramesh Bokka, Immacolata Fiume, Marina Tucci and Gabriella Pocsfalvi
  Plants 2020, 9(12), 1777; https://doi.org/10.3390/plants9121777

• “Feeding Behavior and Virus-transmission Ability of Insect Vectors Exposed to Systemic Insecticides”
  by Elisa Garzo, Aránzazu Moreno, María Plaza and Alberto Fereres
  Plants 2020, 9(7), 895; https://doi.org/10.3390/plants9070895

• “Transcriptome Analyses and Antioxidant Activity Profiling Reveal the Role of a Lignin-Derived Biostimulant Seed Treatment in Enhancing Heat Stress Tolerance in Soybean”
  by Cristina Campobenedetto, Giuseppe Mannino, Chiara Agliassa, Alberto Acquadro, Valeria Contartese, Christian Garabello and Cinzia Margherita Bertea
  Plants 2020, 9(10), 1308; https://doi.org/10.3390/plants9101308

Toxins:

• “Aflatoxin Biosynthesis and Genetic Regulation: A Review”
  by Isaura Caceres, Anthony Al Khoury, Rhoda El Khoury, Sophie Lorber, Isabelle P. Oswald, André El Khoury, Ali Atoui, Olivier Puel and Jean-Denis Bailly
  Toxins 2020, 12(3), 150; https://doi.org/10.3390/toxins12030150

• “Diet Breadth Mediates the Prey Specificity of Venom Potency in Snakes”
  by Keith Lyons, Michel M. Dugon and Kevin Healy
  Toxins 2020, 12(2), 74; https://doi.org/10.3390/toxins12020074

Vaccines:               

• “Rapid Quantification of SARS-CoV-2-Neutralizing Antibodies Using Propagation-Defective Vesicular Stomatitis Virus Pseudotypes”
  by Ferdinand Zettl, Toni Luise Meister, Tanja Vollmer, Bastian Fischer, Jörg Steinmann, Adalbert Krawczyk, Philip V’kovski, Daniel Todt, Eike Steinmann, Stephanie Pfaender et al.
  Vaccines 2020, 8(3), 386; https://doi.org/10.3390/vaccines8030386

• “Influences on Attitudes Regarding Potential COVID-19 Vaccination in the United States”
  by Kendall Pogue, Jamie L. Jensen, Carter K. Stancil, Daniel G. Ferguson, Savannah J. Hughes, Emily J. Mello, Ryan Burgess, Bradford K. Berges, Abraham Quaye and Brian D. Poole
  Vaccines 2020, 8(4), 582; https://doi.org/10.3390/vaccines8040582

• “Recent Progress on the Versatility of Virus-Like Particles”
  by Ciying Qian, Xinlin Liu, Qin Xu, Zhiping Wang, Jie Chen, Tingting Li, Qingbing Zheng, Hai Yu, Ying Gu, Shaowei Li et al.
  Vaccines 2020, 8(1), 139; https://doi.org/10.3390/vaccines8010139

• “COVID-19: Mechanisms of Vaccination and Immunity”
  by Daniel E. Speiser and Martin F. Bachmann
  Vaccines 2020, 8(3), 404; https://doi.org/10.3390/vaccines8030404

Veterinary Sciences:

• “Manure as a Potential Hotspot for Antibiotic Resistance Dissemination by Horizontal Gene Transfer Events”
  by Tiago Lima, Sara Domingues and Gabriela Jorge Da Silva
  Vet. Sci. 2020, 7(3), 110; https://doi.org/10.3390/vetsci7030110

• “Seasonality of Nosema ceranae Infections and Their Relationship with Honey Bee Populations, Food Stores, and Survivorship in a North American Region”
  by Berna Emsen, Alvaro De la Mora, Brian Lacey, Les Eccles, Paul G. Kelly, Carlos A. Medina-Flores, Tatiana Petukhova, Nuria Morfin and Ernesto Guzman-Novoa
  Vet. Sci. 2020, 7(3), 131; https://doi.org/10.3390/vetsci7030131

About MDPI Awards:

In order to reward the academic community, especially young researchers and enhance communication among scientists, MDPI journals regularly offer various awards to researchers in specific fields. These awards, serving as a source of inspiration and recognition, help raise the influence of talented individuals who have been credited with outstanding achievements and are making a significant contribution to the advancement of their fields.

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