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Laccase Properties, Physiological Functions, and Evolution

1
Department of Biochemistry and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19 Street, 20-033 Lublin, Poland
2
Department of Botany, Mycology and Ecology, Maria Curie-Skłodowska University, Akademicka 19 Street, 20-033 Lublin, Poland
3
Professor Emeritus, School of Food Science, University of Idaho, Moscow, ID 83844, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(3), 966; https://doi.org/10.3390/ijms21030966
Received: 14 January 2020 / Revised: 29 January 2020 / Accepted: 30 January 2020 / Published: 31 January 2020
(This article belongs to the Section Biochemistry)
Discovered in 1883, laccase is one of the first enzymes ever described. Now, after almost 140 years of research, it seems that this copper-containing protein with a number of unique catalytic properties is widely distributed across all kingdoms of life. Laccase belongs to the superfamily of multicopper oxidases (MCOs)—a group of enzymes comprising many proteins with different substrate specificities and diverse biological functions. The presence of cupredoxin-like domains allows all MCOs to reduce oxygen to water without producing harmful byproducts. This review describes structural characteristics and plausible evolution of laccase in different taxonomic groups. The remarkable catalytic abilities and broad substrate specificity of laccases are described in relation to other copper-containing MCOs. Through an exhaustive analysis of laccase roles in different taxa, we find that this enzyme evolved to serve an important, common, and protective function in living systems. View Full-Text
Keywords: laccase; function; multicopper oxidase; polyphenol oxidase; lignin; melanin; evolution laccase; function; multicopper oxidase; polyphenol oxidase; lignin; melanin; evolution
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MDPI and ACS Style

Janusz, G.; Pawlik, A.; Świderska-Burek, U.; Polak, J.; Sulej, J.; Jarosz-Wilkołazka, A.; Paszczyński, A. Laccase Properties, Physiological Functions, and Evolution. Int. J. Mol. Sci. 2020, 21, 966. https://doi.org/10.3390/ijms21030966

AMA Style

Janusz G, Pawlik A, Świderska-Burek U, Polak J, Sulej J, Jarosz-Wilkołazka A, Paszczyński A. Laccase Properties, Physiological Functions, and Evolution. International Journal of Molecular Sciences. 2020; 21(3):966. https://doi.org/10.3390/ijms21030966

Chicago/Turabian Style

Janusz, Grzegorz; Pawlik, Anna; Świderska-Burek, Urszula; Polak, Jolanta; Sulej, Justyna; Jarosz-Wilkołazka, Anna; Paszczyński, Andrzej. 2020. "Laccase Properties, Physiological Functions, and Evolution" Int. J. Mol. Sci. 21, no. 3: 966. https://doi.org/10.3390/ijms21030966

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