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Most Cited

  • Systematic Review
  • Open Access
  • Best Paper Award
877 Citations
219,836 Views
15 Pages

26 December 2023

The significant advancements in applying artificial intelligence (AI) to healthcare decision-making, medical diagnosis, and other domains have simultaneously raised concerns about the fairness and bias of AI systems. This is particularly critical in...

(This article belongs to the Section Computer Science, Mathematics and AI)
  • Review
  • Open Access
700 Citations
26,030 Views
10 Pages

Ten Years of Industrie 4.0

  • Henning Kagermann and
  • Wolfgang Wahlster

28 June 2022

A decade after its introduction, Industrie 4.0 has been established globally as the dominant paradigm for the digital transformation of the manufacturing industry. Amalgamating research-based results and practical experience from the German industry,...

(This article belongs to the Special Issue Industry 4.0 – The Global Industrial Revolution: Achievements, Obstacles and Research Needs for the Digital Transformation of Industry)
  • Review
  • Open Access
250 Citations
73,582 Views
19 Pages

Plant-Derived Saponins: A Review of Their Surfactant Properties and Applications

  • Summi Rai,
  • Eliza Acharya-Siwakoti,
  • Ananda Kafle,
  • Hari Prasad Devkota and
  • Ajaya Bhattarai

16 November 2021

In response to increasing natural surfactant demand and environmental concerns, natural plant-based surfactants have been replacing synthetic ones. Saponins belong to a class of plant metabolites with surfactant properties that are widely distributed...

(This article belongs to the Special Issue Feature Papers 2021 Editors Collection)
  • Article
  • Open Access
159 Citations
18,928 Views
20 Pages

6 March 2021

This study investigates the trend in monthly and annual rainfall, minimum and maximum temperature (Tmin and Tmax) using the Mann–Kendall (MK) test and Sen’s slope (SS) method and evaluates the significance of their variability for maize, sorghum and...

(This article belongs to the Section Environmental and Earth Science)
  • Review
  • Open Access
127 Citations
16,459 Views
14 Pages

The Increase of Soil Organic Matter Reduces Global Warming, Myth or Reality?

  • Jose Navarro-Pedreño,
  • María Belén Almendro-Candel and
  • Antonis A. Zorpas

8 March 2021

The soil has lost organic matter in the past centuries. Adding organic matter to soils is one of the management practices applied to recover the levels of soil carbon of the past and to improve soil properties. Is it a good practice to reduce global...

(This article belongs to the Special Issue Feature Papers 2020 Editors' Collection)
  • Article
  • Open Access
100 Citations
33,949 Views
22 Pages

LSTM–Transformer-Based Robust Hybrid Deep Learning Model for Financial Time Series Forecasting

  • Md R. Kabir,
  • Dipayan Bhadra,
  • Moinul Ridoy and
  • Mariofanna Milanova

10 January 2025

The inherent challenges of financial time series forecasting demand advanced modeling techniques for reliable predictions. Effective financial time series forecasting is crucial for financial risk management and the formulation of investment decision...

(This article belongs to the Section Computer Science, Mathematics and AI)
  • Review
  • Open Access
98 Citations
18,334 Views
25 Pages

Apoptosis and Pharmacological Therapies for Targeting Thereof for Cancer Therapeutics

  • Vishakha Singh,
  • Amit Khurana,
  • Umashanker Navik,
  • Prince Allawadhi and ,
  • Kala Kumar Bharani and
  • Ralf Weiskirchen
  • + 1 author+ 0 author

6 April 2022

Apoptosis is an evolutionarily conserved sequential process of cell death to maintain a homeostatic balance between cell formation and cell death. It is a vital process for normal eukaryotic development as it contributes to the renewal of cells and t...

(This article belongs to the Special Issue Feature Papers 2021 Editors Collection)
  • Review
  • Open Access
95 Citations
17,862 Views
24 Pages

21 March 2023

Alzheimer’s Disease (AD) is becoming increasingly prevalent across the globe, and various diagnostic and detection methods have been developed in recent years. Several techniques are available, including Automatic Pipeline Methods and Machine L...

(This article belongs to the Section Computer Science, Mathematics and AI)
  • Review
  • Open Access
70 Citations
26,695 Views
26 Pages

15 December 2023

In recent years, generative transformers have become increasingly prevalent in the field of artificial intelligence, especially within the scope of natural language processing. This paper provides a comprehensive overview of these models, beginning w...

(This article belongs to the Special Issue Computational Linguistics and Artificial Intelligence)
  • Review
  • Open Access
64 Citations
23,957 Views
16 Pages

30 October 2023

Blockchain offers a cutting-edge solution for storing medical data, carrying out medical transactions, and establishing trust for medical data integration and exchange in a decentralized open healthcare network setting. While blockchain in healthcare...

(This article belongs to the Special Issue Feature Papers—Multidisciplinary Sciences 2023)
  • Review
  • Open Access
64 Citations
20,132 Views
37 Pages

9 April 2025

Microbial enzymes have revolutionised the textile industry by replacing harmful chemicals with eco-friendly alternatives, enhancing processes such as desizing, scouring, dyeing, finishing, and promoting water conservation while reducing pollution. Th...

(This article belongs to the Special Issue Feature Papers—Multidisciplinary Sciences 2024)
  • Review
  • Open Access
58 Citations
34,253 Views
24 Pages

Evolving Paradigms of Recombinant Protein Production in Pharmaceutical Industry: A Rigorous Review

  • Achuth Jayakrishnan,
  • Wan Rosalina Wan Rosli,
  • Ahmad Rashidi Mohd Tahir,
  • Fashli Syafiq Abd Razak and ,
  • Phei Er Kee,
  • Hui Suan Ng,
  • Yik-Ling Chew,
  • Siew-Keah Lee,
  • Mahenthiran Ramasamy and
  • Kai Bin Liew
  • + 6 authors+ 1 author

31 January 2024

Many beneficial proteins have limited natural availability, which often restricts their supply and thereby reduces their potential for therapeutic or industrial usage. The advent of recombinant DNA (rDNA) technology enables the utilization of differe...

(This article belongs to the Section Biology Research and Life Sciences)
  • Article
  • Open Access
52 Citations
13,010 Views
17 Pages

5 September 2022

The latest technological development called Industry 4.0, like the previous industrial revolutions, has also brought a new challenge for people as a labor force because new technologies require new skills and competencies. By 2030 the existing genera...

(This article belongs to the Special Issue Industry 4.0 – The Global Industrial Revolution: Achievements, Obstacles and Research Needs for the Digital Transformation of Industry)
  • Article
  • Open Access
50 Citations
10,630 Views
13 Pages

The Digital Calibration Certificate (DCC) for an End-to-End Digital Quality Infrastructure for Industry 4.0

  • Siegfried Hackel,
  • Shanna Schönhals,
  • Lutz Doering,
  • Thomas Engel and
  • Reinhard Baumfalk

6 March 2023

This article depicts the role of the Digital Calibration Certificate (DCC) for an end-to-end digital quality infrastructure and as the basis for developments that are designated by the keyword “Industry 4.0”. Furthermore, it describes the...

(This article belongs to the Special Issue Industry 4.0 – The Global Industrial Revolution: Achievements, Obstacles and Research Needs for the Digital Transformation of Industry)
  • Review
  • Open Access
44 Citations
35,951 Views
38 Pages

Challenges and Opportunities in the Implementation of AI in Manufacturing: A Bibliometric Analysis

  • Lorena Espina-Romero,
  • Humberto Gutiérrez Hurtado,
  • Doile Ríos Parra,
  • Rafael Alberto Vilchez Pirela and ,
  • Rosa Talavera-Aguirre and
  • Angélica Ochoa-Díaz
  • + 1 author+ 0 author

3 October 2024

This study explores the evolution and impact of research on the challenges and opportunities in the implementation of artificial intelligence (AI) in manufacturing between 2019 and August 2024. By addressing the growing integration of AI technologies...

(This article belongs to the Special Issue Industry 4.0—New Entrepreneurial Opportunities: How to Make Money with AI in Manufacturing)
  • Article
  • Open Access
41 Citations
6,611 Views
18 Pages

Assessment of Habitat Change Processes within the Oti-Keran-Mandouri Network of Protected Areas in Togo (West Africa) from 1987 to 2013 Using Decision Tree Analysis

  • Aniko Polo-Akpisso,
  • Kperkouma Wala,
  • Ouattara Soulemane,
  • Fousseni Folega and ,
  • Koffi Akpagana and
  • Yao Tano
  • + 1 author+ 0 author

1 January 2020

Biodiversity conservation planning is highly important in the current context of global change. Biodiversity conservation can be achieved by understanding changes in land use at the landscape scale. Such understanding is needed to reverse the unprece...

  • Article
  • Open Access
38 Citations
10,367 Views
11 Pages

6 March 2025

Inverse Distance Weighting (IDW) is a common method for spatial interpolation. Still, its accuracy decreases when there is a cluster of measurement stations or when some measuring stations are hidden behind others. This paper introduces Clusters Unif...

(This article belongs to the Section Environmental and Earth Science)
  • Article
  • Open Access
36 Citations
2,956 Views
16 Pages

An Explainable Multi-Model Stacked Classifier Approach for Predicting Hepatitis C Drug Candidates

  • Teuku Rizky Noviandy,
  • Aga Maulana,
  • Ghifari Maulana Idroes,
  • Rivansyah Suhendra and ,
  • Razief Perucha Fauzie Afidh and
  • Rinaldi Idroes
  • + 1 author+ 0 author

6 December 2024

Hepatitis C virus (HCV) infection affects over 71 million people worldwide, leading to severe liver diseases, including cirrhosis and hepatocellular carcinoma. The virus’s high mutation rate complicates current antiviral therapies by promoting...

(This article belongs to the Section Computer Science, Mathematics and AI)
  • Review
  • Open Access
36 Citations
17,839 Views
17 Pages

Role of Peripheral Immune Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

  • Sarah Dhaiban,
  • Mena Al-Ani,
  • Noha Mousaad Elemam,
  • Mahmood H. Al-Aawad and ,
  • Zeinab Al-Rawi and
  • Azzam A. Maghazachi
  • + 1 author+ 0 author

1 February 2021

Multiple sclerosis (MS) is a chronic autoimmune disease that affects the myelination of the neurons present in the central nervous system (CNS). The exact etiology of MS development is unclear, but various environmental and genetic factors might play...

  • Article
  • Open Access
34 Citations
8,099 Views
22 Pages

Evaluation of Dissolution Enhancement of Aprepitant Drug in Ternary Pharmaceutical Solid Dispersions with Soluplus® and Poloxamer 188 Prepared by Melt Mixing

  • Stavroula Nanaki,
  • Rodanthi Maria Eleftheriou,
  • Panagiotis Barmpalexis,
  • Margaritis Kostoglou and ,
  • Evangelos Karavas and
  • Dimitrios Bikiaris
  • + 1 author+ 0 author

15 August 2019

In the present study Aprepitant (APT) ternary solid dispersions (SDs) were developed and evaluated for the first time. Specifically, ternary SDs of APT with Poloxamer 188 and Soluplus® (SOL) were prepared via melt mixing and compared to binary AP...

  • Review
  • Open Access
34 Citations
8,129 Views
10 Pages

Endocrine Disrupting Compounds Removal Methods from Wastewater in the United Kingdom: A Review

  • China K. Gadupudi,
  • Louis Rice,
  • Libin Xiao and
  • Komali Kantamaneni

1 February 2021

Endocrine disrupting compounds (EDCs) are contaminants with estrogenic or androgenic activity that negatively impact human and animal communities. These compounds have become one of the most significant concerns for wastewater treatment in recent dec...

(This article belongs to the Section Environmental and Earth Science)
  • Concept Paper
  • Open Access
34 Citations
9,270 Views
16 Pages

Digital Twins in Manufacturing: A RAMI 4.0 Compliant Concept

  • Martin Lindner,
  • Lukas Bank,
  • Johannes Schilp and
  • Matthias Weigold

10 October 2023

Digital twins are among the technologies that are considered to have high potential. At the same time, there is no uniform understanding of what this technology means. Definitions are used across disciplinary boundaries, resulting in a multitude of d...

(This article belongs to the Special Issue Industry 4.0 – The Global Industrial Revolution: Achievements, Obstacles and Research Needs for the Digital Transformation of Industry)
  • Review
  • Open Access
32 Citations
9,514 Views
27 Pages

A Review of the State of the Art for the Internet of Medical Things

  • Peter Matthew,
  • Sarah Mchale,
  • Xutao Deng,
  • Ghada Nakhla and ,
  • Marcello Trovati,
  • Nonso Nnamoko,
  • Ella Pereira,
  • Huaizhong Zhang and
  • Mohsin Raza
  • + 4 authors+ 0 author

24 March 2025

The technological developments in the Internet of Things (IoT), data science, artificial intelligence, wearable sensors, remote monitoring, decision support systems, fog, and edge systems have transformed digital healthcare. Especially after the pand...

(This article belongs to the Special Issue Feature Papers—Multidisciplinary Sciences 2024)
  • Review
  • Open Access
32 Citations
19,620 Views
14 Pages

LC–NMR for Natural Product Analysis: A Journey from an Academic Curiosity to a Robust Analytical Tool

  • Tesfay Gebretsadik,
  • Wolfgang Linert,
  • Madhu Thomas,
  • Tarekegn Berhanu and
  • Russell Frew

6 January 2021

Liquid chromatography (LC)–nuclear magnetic resonance (NMR) combines the advantage of the outstanding separation power of liquid chromatography (LC) and the superior structural elucidating capability of nuclear magnetic resonance (NMR). NMR has...

  • Article
  • Open Access
32 Citations
8,318 Views
17 Pages

Transport Properties of Nanostructured Li2TiO3 Anode Material Synthesized by Hydrothermal Method

  • Ambadi Lakshmi-Narayana,
  • Obili M. Hussain,
  • Alain Mauger and
  • Christian Julien

20 September 2019

Li2TiO3 nanopowders were synthesized by hydrothermal process using anatase TiO2 and LiOHH2O as raw materials. Li2TiO3 crystallizes in the layered monoclinic structure (space group C2/c) with average crystallite size of 34 nm. Morphology, elemental co...

(This article belongs to the Section Chemistry Science)
  • Article
  • Open Access
32 Citations
34,213 Views
33 Pages

Atmospheric Temperature and CO2: Hen-Or-Egg Causality?

  • Demetris Koutsoyiannis and
  • Zbigniew W. Kundzewicz

25 November 2020

It is common knowledge that increasing CO2 concentration plays a major role in enhancement of the greenhouse effect and contributes to global warming. The purpose of this study is to complement the conventional and established theory, that increased...

(This article belongs to the Special Issue Feature Papers 2020 Editors' Collection)
  • Article
  • Open Access
31 Citations
10,511 Views
12 Pages

2 April 2024

Audio classification using deep learning models, which is essential for applications like voice assistants and music analysis, faces challenges when deployed on edge devices due to their limited computational resources and memory. Achieving a balance...

(This article belongs to the Special Issue Feature Papers—Multidisciplinary Sciences 2023)
  • Article
  • Open Access
31 Citations
8,673 Views
16 Pages

Static and Dynamic Evaluation of an UWB Localization System for Industrial Applications

  • Mickaël Delamare,
  • Remi Boutteau,
  • Xavier Savatier and
  • Nicolas Iriart

3 April 2020

Many applications in the context of Industry 4.0 require precise localization. However, indoor localization remains an open problem, especially in complex environments such as industrial environments. In recent years, we have seen the emergence of Ul...

  • Review
  • Open Access
31 Citations
8,262 Views
17 Pages

20 March 2019

One of the important features of polymethine (cyanine) dyes is isomerization about one of C–C bonds of the polymethine chain. In this review, spectral properties of the isomers, photoisomer-ization and thermal back isomerization of carbocyanine dyes,...

(This article belongs to the Section Chemistry Science)
  • Systematic Review
  • Open Access
29 Citations
7,253 Views
36 Pages

3 December 2025

Artificial intelligence (AI) is transforming pharmaceutical science by shifting drug delivery research from empirical experimentation toward predictive, data-driven innovation. This review critically examines the integration of AI across formulation...

  • Article
  • Open Access
28 Citations
8,182 Views
22 Pages

28 March 2023

This paper draws upon the United Nations 2022 data report on the achievement of Sustainable Development Goals (SDGs) across the following four dimensions: economic, social, environmental and institutional. Ward’s method was applied to obtain cl...

(This article belongs to the Section Computer Science, Mathematics and AI)
  • Review
  • Open Access
27 Citations
12,050 Views
17 Pages

An Overview on Spheroid and Organoid Models in Applied Studies

  • Zorislava Živković and
  • Teuta Opačak-Bernardi

4 March 2025

From its inception, cell culture has been a great scientific tool for researchers in many diverse fields. The advancement from monolayer 2D cultures into three-dimensional cellular systems enabled a better experimental tool, as the 3D culture mimics...

(This article belongs to the Section Biology Research and Life Sciences)
  • Article
  • Open Access
27 Citations
10,415 Views
21 Pages

5 May 2021

Urban growth in various cities across the world, especially in developing countries, leads to land use change. Thus, predicting future urban growth in the most rapidly growing region of Nigeria becomes a significant endeavor. This study analyzes land...

(This article belongs to the Special Issue Feature Papers 2020 Editors' Collection)
  • Review
  • Open Access
27 Citations
17,436 Views
26 Pages

A Survey on EEG Data Analysis Software

  • Rupak Kumar Das,
  • Anna Martin,
  • Tom Zurales,
  • Dale Dowling and
  • Arshia Khan

1 June 2023

Electroencephalography (EEG) is a mechanism to understand the brain’s functioning by analyzing brain electrical signals. More recently, it has been more commonly used in studies that are focused on the causation and effect of dementia. More too...

(This article belongs to the Section Computer Science, Mathematics and AI)
  • Review
  • Open Access
25 Citations
12,100 Views
21 Pages

4 February 2024

Petrochemical feedstocks are experiencing a fast growth in demand, which will further expand their market in the coming years. This is due to an increase in the demand for petrochemical-based materials that are used in households, hospitals, transpor...

(This article belongs to the Section Chemistry Science)
  • Article
  • Open Access
25 Citations
8,438 Views
15 Pages

Yield and Composition Variations of the Milk from Different Camel Breeds in Saudi Arabia

  • Amr A. El-Hanafy,
  • Yasser M. Saad,
  • Saleh A. Alkarim,
  • Hussein A. Almehdar and ,
  • Fuad M. Alzahrani,
  • Mohammed A. Almatry,
  • Vladimir N. Uversky and
  • Elrashdy M. Redwan
  • + 3 authors+ 0 author

6 January 2023

With the increasing interest in the identification of differences between camel breeds over the last decade, this study was conducted to estimate the variability of milk production and composition of four Saudi camel breeds during different seasons....

(This article belongs to the Section Biology Research and Life Sciences)
  • Review
  • Open Access
25 Citations
5,387 Views
16 Pages

Microbiota Status and Endometrial Cancer: A Narrative Review About Possible Correlations in Affected Versus Healthy Patients

  • Carmen Imma Aquino,
  • Anthony Nicosia,
  • Arianna Ligori,
  • Agnese Immacolata Volpicelli and
  • Daniela Surico

7 November 2024

(1) Background: Microbiota could be related to tumorigenesis through the persistence of an inflammatory state, also at the endometrial level. Inflammation, in fact, is involved in the promotion of genetic instability and in a favorable microenvironme...

(This article belongs to the Special Issue One Health)
  • Article
  • Open Access
24 Citations
8,799 Views
21 Pages

2 August 2024

This study investigates the potential health risks associated with consuming mussels (Mytilus galloprovincialis Lamarck, 1819) from the Romanian Black Sea coast between 2001 and 2023. The research focuses on heavy metal (copper, cadmium, lead, nickel...

(This article belongs to the Special Issue Feature Papers—Multidisciplinary Sciences 2024)
  • Review
  • Open Access
22 Citations
7,755 Views
40 Pages

Advancements of Biohydrogen Production Based on Anaerobic Digestion: Technologies, Substrates, and Future Prospects

  • Rossana Parra,
  • Cristhian Chicaiza-Ortiz,
  • Robinson J. Herrera-Feijoo,
  • Diana Victoria Arellano-Yasaca and ,
  • Lien-Chieh Lee,
  • Roberto Xavier Supe-Tulcan and
  • Jaime Marti-Herrero
  • + 2 authors+ 0 author

29 April 2025

Population growth has significantly increased energy and resource demands, driving research toward cost-effective technologies that repurpose waste into alternative energy forms such as biohydrogen. This review aims to comprehensively evaluate biohyd...

  • Review
  • Open Access
22 Citations
12,641 Views
22 Pages

Pesticides in the Environment: Benefits, Harms, and Detection Methods

  • Francis Xavier D. Verdadero,
  • Alfred Z. Agarap,
  • Czarina Nicole E. Macatingrao,
  • Isagani A. Ordonez and ,
  • Lady Edlenill J. Tavu,
  • David Pires and
  • Mark Angelo O. Balendres
  • + 2 authors+ 0 author

21 November 2025

Pesticides play a critical role in food production by enhancing crop yields and protecting against pests and pathogens, such as insects, bacteria, fungi, and weeds. However, their extensive use raises significant environmental concerns. The paper rev...

(This article belongs to the Section Biology Research and Life Sciences)
  • Article
  • Open Access
22 Citations
12,109 Views
10 Pages

12 January 2023

A signature of synaptic potentiation conductance has been observed in an α-Fe2O3/p-Si device fabricated using spin coating. The conductance of the device in dark conditions and illumination with a white light source was characterized as a funct...

  • Article
  • Open Access
22 Citations
4,706 Views
14 Pages

Non-Flammable Epoxy Composition Based on Epoxy Resin DER-331 and 4-(β-Carboxyethenyl)phenoxy-phenoxycyclotriphosphazenes with Increased Adhesion to Metals

  • Anastasia Konstantinova,
  • Pavel Yudaev,
  • Aleksey Shapagin,
  • Darya Panfilova and ,
  • Aleksandr Palamarchuk and
  • Evgeniy Chistyakov
  • + 1 author+ 0 author

23 May 2024

Functional cyclophosphazenes have proven to be effective modifiers of polymer materials, significantly improving their performance properties, such as adhesive characteristics, mechanical strength, thermal stability, fire resistance, etc. In this stu...

(This article belongs to the Section Chemistry Science)
  • Article
  • Open Access
21 Citations
3,099 Views
43 Pages

Smart Energy Strategy for AC Microgrids to Enhance Economic Performance in Grid-Connected and Standalone Operations: A Gray Wolf Optimizer Approach

  • Sebastian Lobos-Cornejo,
  • Luis Fernando Grisales-Noreña,
  • Fabio Andrade,
  • Oscar Danilo Montoya and
  • Daniel Sanin-Villa

3 June 2025

This study proposes an optimized energy management strategy for alternating current microgrids, integrating wind generation, battery energy storage systems (BESSs), and distribution static synchronous compensators (D-STATCOMs). The objective is to mi...

  • Systematic Review
  • Open Access
21 Citations
5,039 Views
28 Pages

7 January 2026

The integration of artificial intelligence into the Industrial Internet of Things (IIoT), supported by edge computing architectures, marks a new paradigm of intelligent automation. Tiny Machine Learning (TinyML) is emerging as a key technology that e...

(This article belongs to the Section Computer Science, Mathematics and AI)
  • Article
  • Open Access
21 Citations
6,684 Views
14 Pages

27 November 2020

This study assessed farmers’ perception of climate change, and estimated the determinants of, and evaluated the relationship among, adaptation practices using the multivariate probit model. A survey in 300 agricultural households was carried ou...

(This article belongs to the Section Environmental and Earth Science)
  • Review
  • Open Access
21 Citations
12,320 Views
30 Pages

Anti-Aging Potential of Bioactive Phytoconstituents Found in Edible Medicinal Plants: A Review

  • Emeka Joshua Iweala,
  • Oluwapelumi Eniola Adurosakin,
  • Ugochukwu Innocent,
  • Conrad A. Omonhinmin and ,
  • Omoremime Elizabeth Dania and
  • Eziuche Amadike Ugbogu
  • + 1 author+ 0 author

13 June 2024

Aging is a complex biological and physiological change that leads to a loss of function in all living organisms. Although the mechanism behind the aging process is still largely unknown, scientific studies have shown that oxidative stress and age-rel...

(This article belongs to the Section Biology Research and Life Sciences)
  • Review
  • Open Access
20 Citations
11,769 Views
22 Pages

Aromaticity Concepts Derived from Experiments

  • Halina Szatylowicz,
  • Paweł A. Wieczorkiewicz and
  • Tadeusz M. Krygowski

9 June 2022

Aromaticity, a very important term in organic chemistry, has never been defined unambiguously. Various ways to describe it come from different phenomena that have been experimentally observed. The most important examples related to some theoretical c...

(This article belongs to the Special Issue Define What Is Not Defined: In Chemistry and Beyond)
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