Advances in G Protein-Coupled Receptor Signaling

Dear Colleagues,

G protein-coupled receptors (GPCRs) are the largest family of metabotropic receptors, constituting eukaryotes’ largest and most diverse group of membrane receptors. Despite distinguishing five structurally distinct subfamilies (glutamate, rhodopsin, adhesion, frizzled/taste2, and secretin) within the GPCRs superfamily, these integral membrane proteins contain invariably an extracellular amino terminus, seven transmembrane (7TM) α-helical domains, and an intracellular carboxy terminus. Among the nearly 800 GPCRs encoded in the human genome, those associated with signaling pathways influence the inflammatory response and metabolism.

The anti-inflammatory and metabolic effects of signaling through GPCRs are of understandable interest due to their potential therapeutic possibilities, including in frequently occurring metabolic diseases accompanied by inflammation, such as overweight/obesity, atherosclerosis, type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD).

This Special Issue is dedicated to all aspects of GPCR signaling, including physiological and pathologic conditions with direct or indirect anti-inflammatory and metabolic effects.

When considering your submission, please remember that IJMS is a journal of molecular science. However, submissions of clinical studies that include biomolecular experiments or pathological research with case sample data are welcomed.

Prof. Dr. Dariusz Szukiewicz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the Special Issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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