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FTIR Miscrospectroscopy: Opportunities and Challenges
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FTIR Miscrospectroscopy: Opportunities and Challenges

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Physical Chemistry and Chemical Physics".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 3793

Special Issue Editor

Dr. Simona Sabbatini

E-Mail Website
Guest Editor
SIMAU Department of the Faculty of Engineering, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, AN, Italy
Interests: FTIR microspectroscopy; biodegradable polymers; spectral characterization of biological, organic and inorganic samples

Special Issue Information

Dear Colleagues,

Fourier-transform infrared (FTIR) spectroscopy is one of the most powerful experimental methods for probing the molecular structure and dynamics of a variety of systems. The most important features of this method are non-destructive, real-time measurements and relative ease of use. Therefore, this technology is widely used in medicine, physics, chemistry, and food science fields. Additionally, it will help related research to more accurately define the chemical structure of biological tissues and guide the development of more models and more detailed research systems.

The purpose of this Special Issue is to collect new opportunities and challenges for the study of physical chemistry and related molecular structure and dynamics by FTIR spectroscopic techniques and their computational methods. Particular emphasis will be placed on innovative approaches applied at the molecular level and results of broad scientific relevance.

Dr. Simona Sabbatini
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Published Papers (2 papers)

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Research

16 pages, 3734 KiB  
Article
Human Primary Lens Epithelial Cultures on Basal Laminas Studied by Synchrotron-Based FTIR Microspectroscopy for Understanding Posterior Capsular Opacification
by Sofija Andjelic and Marko Hawlina
Int. J. Mol. Sci. 2024, 25(16), 8858; https://doi.org/10.3390/ijms25168858 - 14 Aug 2024
Viewed by 904
Abstract
Human primary lens epithelial cultures serve as an in vitro model for posterior capsular opacification (PCO) formation. PCO occurs when residual lens epithelial cells (LECs) migrate and proliferate after cataract surgery, differentiating into fibroblastic and lens fiber-like cells. This study aims to show [...] Read more.
Human primary lens epithelial cultures serve as an in vitro model for posterior capsular opacification (PCO) formation. PCO occurs when residual lens epithelial cells (LECs) migrate and proliferate after cataract surgery, differentiating into fibroblastic and lens fiber-like cells. This study aims to show and compare the bio-macromolecular profiles of primary LEC cultures and postoperative lens epithelia LECs on basal laminas (bls), while also analyzing bls and cultured LECs separately. Using synchrotron radiation-based Fourier transform infrared (SR-FTIR) (Bruker, Karlsruhe, Germany) microspectroscopy at the Spanish synchrotron light source ALBA, we observed that the SR-FTIR measurements were predominantly influenced by the strong collagen absorbance of the bls. Cultured LECs on bls showed a higher collagen contribution, indicated by higher vas CH3, CH2 and CH3 wagging and deformation, and the C–N stretching of collagen. In contrast, postoperative LECs on bls showed a higher cell contribution, indicated by the vsym CH2 peak and the ratio between vas CH2 and vas CH3 peaks. The primary difference revealed using SR-FTIR is the greater LEC contribution in spectra recorded from postoperative lens epithelia compared to cultured LECs on bls. IR spectra for bl, cultured LECs and postoperative lens epithelia could be valuable for future research. Full article
(This article belongs to the Special Issue FTIR Miscrospectroscopy: Opportunities and Challenges)
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17 pages, 4197 KiB  
Article
The Study of Amorphous Kaempferol Dispersions Involving FT-IR Spectroscopy
by Natalia Rosiak, Ewa Tykarska and Judyta Cielecka-Piontek
Int. J. Mol. Sci. 2023, 24(24), 17155; https://doi.org/10.3390/ijms242417155 - 5 Dec 2023
Cited by 8 | Viewed by 1829
Abstract
Attenuated total reflection-Mid-Fourier transform-infrared (ATR-Mid-FT-IR) spectroscopy combined with principal component analysis (PCA) has been applied for the discrimination of amorphous solid dispersion (ASD) of kaempferol with different types of Eudragit (L100, L100-55, EPO). The ASD samples were prepared by ball milling. Training and [...] Read more.
Attenuated total reflection-Mid-Fourier transform-infrared (ATR-Mid-FT-IR) spectroscopy combined with principal component analysis (PCA) has been applied for the discrimination of amorphous solid dispersion (ASD) of kaempferol with different types of Eudragit (L100, L100-55, EPO). The ASD samples were prepared by ball milling. Training and test sets for PCA consisted of a pure compound, physical mixture, and incomplete/complete amorphous solid dispersion. The obtained results confirmed that the range 400–1700 cm−1 was the major contributor to the variance described by PC1 and PC2, which are the fingerprint region. The obtained PCA model selected fully amorphous samples as follows: five for KMP-EL100, two for KMP-EL100-55, and six for KMP-EPO (which was confirmed by the XRPD analysis). DSC analysis confirmed full miscibility of all ASDs (one glass transition temperature). FT-IR analysis confirmed the formation of hydrogen bonds between the –OH and/or –CH groups of KMP and the C=O group of Eudragits. Amorphization improved the solubility of kaempferol in pH 6.8, pH 5.5, and HCl 0.1 N. Full article
(This article belongs to the Special Issue FTIR Miscrospectroscopy: Opportunities and Challenges)
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