Molecular Research on Potential New Antidepressant Drugs
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 186
Special Issue Editors
Interests: antidepressant drug discovery; treatment-resistant depression; neuroinflammation; neuroplasticity; hallucinogens and psychedelics; CNS drug development; molecular targets for depression; neurotransmitter systems; preclinical research; psychiatric disorders
Interests: neurochemistry; neurotransmitter dysregulation; histamine receptors; neurodegenerative diseases; multi-targeting drugs; experimental animal models
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Special Issue Information
Dear Colleagues,
Despite advances in neuroscience, effective treatment options for depression, particularly treatment-resistant depression, remain limited. The search for new antidepressant drugs requires deeper exploration of the brain's molecular landscape, especially the intricate network of neurotransmitters and signaling pathways involved in mood regulation.
Serotonin, norepinephrine, and dopamine have long been central to the development of antidepressants, but recent studies highlight the importance of other molecular targets, such as glutamate receptors, neurotrophic factors, and inflammatory markers. The discovery of novel compounds and multitarget drugs that can modulate these systems offers hope for more effective therapies with fewer side effects.
We welcome contributions focusing on the identification of new molecular targets, the synthesis of innovative compounds, and the pharmacological evaluation of potential antidepressants. The submission of preclinical research, including in vitro and in vivo studies on novel mechanisms of action, is particularly encouraged, especially in the context of treatment-resistant depression. This Special Issue will feature original research and review articles focused on the development of novel pharmacological agents, their mechanisms of action, and the molecular pathways involved.
Dr. Marta Jóźwiak-Bębenista
Dr. Anna Stasiak
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- antidepressant drug discovery
- treatment-resistant depression
- neuroinflammation
- neuroplasticity
- hallucinogens and psychedelics
- CNS drug development
- molecular targets for depression
- neurotransmitter systems (serotonin, norepinephrine, dopamine)
- preclinical research (in vitro, in vivo, in silico)
- psychiatric disorders
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