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Medical Applications of Polymer Materials

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: 25 October 2025 | Viewed by 450

Special Issue Editor


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Guest Editor
School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510275, China
Interests: synthesis and self-assembly of polymer materials; synthesis of upconversion nanoparticles; construction of advanced assemblies and their biomedical applications
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Special Issue Information

Dear Colleagues,

Polymer materials play a pivotal role in advancing modern medicine due to their excellent biocompatibility, chemical tunability, mechanical flexibility, and ease of fabrication. These materials support a wide array of biomedical applications, including controlled drug delivery systems, tissue engineering scaffolds, implantable devices, wound dressings, and diagnostic tools. As the medical field moves toward precision, personalized, and regenerative therapies, the demand for next-generation polymeric systems with tailored functionalities and clinical translatability is rapidly increasing. This Special Issue aims to capture the latest progress in the design, synthesis, characterization, and biomedical development and applications of polymer-based materials. We welcome original research articles and reviews on topics including, but not limited to, the following:

(1) Biodegradable, bioresorbable, or responsive polymers for drug delivery;

(2) Polymer scaffolds for tissue regeneration and organ repair;

(3) Functional hydrogels for wound healing and responsive drug release;

(4) Nanocomposites for advanced imaging and theranostic applications;

(5) Surface-engineered polymers with enhanced bioactivity, antibacterial performance, or immune modulation.

Dr. Zhen Zhang
Guest Editor

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Keywords

  • medical polymers
  • drug delivery
  • tissue engineering
  • medical devices
  • diagnostics

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Published Papers (1 paper)

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Review

44 pages, 11501 KiB  
Review
Tissue Regeneration of Radiation-Induced Skin Damages Using Protein/Polysaccharide-Based Bioengineered Scaffolds and Adipose-Derived Stem Cells: A Review
by Stefana Avadanei-Luca, Isabella Nacu, Andrei Nicolae Avadanei, Mihaela Pertea, Bogdan Tamba, Liliana Verestiuc and Viorel Scripcariu
Int. J. Mol. Sci. 2025, 26(13), 6469; https://doi.org/10.3390/ijms26136469 - 4 Jul 2025
Viewed by 327
Abstract
Radiation therapy, a highly effective cancer treatment that targets cancer cells, may produce challenging side effects, including radiation-induced skin tissue injuries. The wound healing process involves complex cellular responses, with key phases including hemostasis, inflammation, proliferation, and remodeling. However, radiation-induced injuries disrupt this [...] Read more.
Radiation therapy, a highly effective cancer treatment that targets cancer cells, may produce challenging side effects, including radiation-induced skin tissue injuries. The wound healing process involves complex cellular responses, with key phases including hemostasis, inflammation, proliferation, and remodeling. However, radiation-induced injuries disrupt this process, resulting in delayed healing, excessive scarring, and compromised tissue integrity. This review explores innovative approaches related to wound healing in post-radiotherapy defects, focusing on the integration of adipose-derived stem cells (ADSCs) in protein/polysaccharide bioengineered scaffolds. Such scaffolds, like hydrogels, sponges, or 3D-printed/bioprinted materials, provide a biocompatible and biomimetic environment that supports cell-to-cell and cell-to-matrix interactions. Various proteins and polysaccharides are discussed for beneficial properties and limitations, and their compatibility with ADSCs in wound healing applications. The potential of ADSCs-polymeric scaffold combinations in radiation-induced wound healing is investigated, alongside the mechanisms of cell proliferation, inflammation reduction, angiogenesis promotion, collagen formation, integrin binding, growth factor signaling, and activation of signaling pathways. New strategies to improve the therapeutic efficacy of ADSCs by integration in adaptive polymeric materials and designed scaffolds are highlighted, providing solutions for radiation-induced wounded skin, personalized care, faster tissue regeneration, and, ultimately, enhanced quality of the patients’ lives. Full article
(This article belongs to the Special Issue Medical Applications of Polymer Materials)
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