Advances of Organic Synthesis in Drug Discovery
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 723
Special Issue Editor
Special Issue Information
Dear Colleagues,
Although the advances in drug discovery made in past decades are very remarkable and very significant, organic synthesis approaches remain a limiting factor in drug-development projects. The need to further expand synthetic methodologies and develop new ones regarding drug design is becoming more pressing. Notable synthesis challenges arise due to the fact that many drug molecules include amines and N-heterocycles, along with unprotected polar groups. There is also a demand for new reactions that allow unconventional disconnections, photoredox chemistry, new catalysts for cross-coupling reactions, more C–H bond activation, and late-stage functionalization, as well as stereoselectively substituted heterocyclic ring synthesis and C–X or C–C bond creation towards the preparation of drug-like molecules. Given the recent technological advances, of great interest are the syntheses that work well with biomacromolecules, while new technologies for synthesis planning could significantly speed up the drug-development process. Additionally, partnerships between industry and academia are very important and valuable in creating innovative methods to design new molecules that could be good candidates for future drugs. In this Special Issue, we are pleased to invite original manuscripts focusing on advances in organic synthesis in drug discovery.
Dr. Laura Gabriela Sârbu
Guest Editor
Manuscript Submission Information
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Keywords
- organic synthesis
- drug design
- heterocyclic chemistry
- functionalization
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