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Targeted Therapies and Molecular Methods in Cancer, 3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (20 April 2025) | Viewed by 1515

Special Issue Editor


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Guest Editor
Department of Molecular and Cellular Biology, Wroclaw Medical University, 50-367 Wroclaw, Poland
Interests: drug delivery; drug resistance; electroporation; photodynamic therapy; oxidative stress and free radicals; natural chemotherapeutics; nanotechnology
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Special Issue Information

Dear Colleagues,

This Special Issue of IJMS continues on from “Targeted Therapies and Molecular Methods in Cancer” and “Targeted Therapies and Molecular Methods in Cancer, 2nd Edition”, examining targeted strategies for dealing with cancer. We welcome articles on new targeted anticancer methods, novel drug delivering routes, and innovative approaches including, but not limited to, the following: immunotherapy; new aspects of radiotherapy; methods to facilitate drug delivery, such as pulsed electric fields (PEFs), sonoporation, magnetic fields (MFs), nanotechnology, and nanocarriers; and gene electrotransfer using PEFs. Targeted anticancer methods can focus on membrane proteins and ion channel alterations. Additionally, targets can be specific surface receptors (ERs, estrogen receptors; FARs, folic acid receptors; and HARs, hyaluronic acid receptors) or cancer biomarkers. Research targeting drug resistance (MDR), aimed at bypassing or modifying the activity of drug transporters, i.e., MDR1/P-gp, MRP1, BCRP, and LRP, will be of interest. We also welcome new and more effective protocols which could be developed and find potential applications in pharmacy and medical sciences. This Special Issue will cover the latest research concerning targeted therapies and molecular methods against cancer.

Dr. Julita Kulbacka
Guest Editor

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Keywords

  • immunotherapy
  • radiotherapy
  • methods using facilitated drug delivery such as electroporation, sonoporation, and magnetic fields
  • nanotechnology and nanocarriers
  • gene electrotherapy
  • intelligent predicting methods with AI

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Published Papers (1 paper)

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Research

17 pages, 4554 KiB  
Article
Cytotoxic Activity of Curcumin- and Resveratrol-Loaded Core–Shell Systems in Resistant and Sensitive Human Ovarian Cancer Cells
by Joanna Weżgowiec, Zofia Łapińska, Łukasz Lamch, Anna Szewczyk, Jolanta Saczko, Julita Kulbacka, Mieszko Więckiewicz and Kazimiera A. Wilk
Int. J. Mol. Sci. 2025, 26(1), 41; https://doi.org/10.3390/ijms26010041 - 24 Dec 2024
Cited by 1 | Viewed by 989
Abstract
Due to the high mortality rate of ovarian cancer, there is a need to find novel strategies to improve current treatment modalities. Natural compounds offer great potential in this field but also require the careful design of systems for their delivery to cancer [...] Read more.
Due to the high mortality rate of ovarian cancer, there is a need to find novel strategies to improve current treatment modalities. Natural compounds offer great potential in this field but also require the careful design of systems for their delivery to cancer cells. Our study explored the anticancer effects of novel resveratrol (RSV)- and curcumin (CUR)-loaded core–shell nanoparticles in human ovarian cancer cells. We evaluated the in vitro cytotoxicity of various nanocarriers (CUR 1-3, RSV I-III) delivered to MDAH-2774 and SKOV-3 cells in comparison to free RVS and CUR after 24 h and 72 h treatment. A two-way ANOVA was applied to compare the results of the MTT assay. Confocal laser scanning microscopy was employed to visualize cellular uptake and mitochondrial localization. Our findings revealed that the cytotoxicity of the core–shell nanoparticles with RSV was not significant, but the systems loaded with CUR effectively decreased the viability of cells. The MDAH-2774 cell line was more sensitive to the treatment than SKOV-3. The enhanced cellular uptake of CUR delivered by core–shell systems and its colocalization with mitochondria were demonstrated. Further research focused on the detailed biological effects of the most effective systems (CUR 2 and CUR 3) should be conducted to provide detailed insights. These findings highlight the promising role of CUR-loaded nanoparticles in ovarian cancer treatment. Full article
(This article belongs to the Special Issue Targeted Therapies and Molecular Methods in Cancer, 3rd Edition)
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