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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cutting-Edge Research and Advancements in Neurodegenerative Diseases
edited by Meera Soundararajan
submission deadline 25 May 2026 | Viewed by 303 | Submission Open
Keywords: neurodegenerative disorders; neurons; Alzheimer’ s disease; Parkinsons disease; Amyotrophic Lateral Sclerosis (ALS); prion diseases; Huntington  disease
(This special issue belongs to the Section Molecular Neurobiology)
Cross-Kingdom Conversations: Deciphering Molecular Interactions in Microorganisms and Plants
edited by Eun-Hae Kwon
submission deadline 25 May 2026 | Viewed by 239 | Submission Open
Keywords: plant– microbe interactions; cross-kingdom signaling; plant growth-promoting microorganisms (PGPMs); molecular communication; synthetic microbial communities (SynComs)
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms in Mucosal Immunity
edited by
submission deadline 25 May 2026 | Viewed by 234 | Submission Open
Keywords: mucosal immunity; metabolism; innate memory; trainers and inflammatory stimuli
(This special issue belongs to the Section Molecular Immunology)
Biogenic and Bioinspired Nanomaterials: Sustainable Strategies for Biomedical Applications
edited by
submission deadline 25 May 2026 | Viewed by 193 | Submission Open
Keywords: biogenic nanomaterials; bioinspired materials; green synthesis; sustainable biomaterials; bio-medical applications; natural extracts; regenerative medicine
(This special issue belongs to the Section Molecular Nanoscience)
Virus Detection and Analysis: Molecular Investigations
edited by
submission deadline 26 May 2026 | Viewed by 271 | Submission Open
Keywords: virus; molecular detection; nucleic acid amplification; molecular typing; next generation sequencing; metagenomics; point-of-care testing
(This special issue belongs to the Section Molecular Microbiology)
Novel Therapeutic Strategies Targeting Cancer Stem Cells
edited by Luciano Vellón
submission deadline 28 May 2026 | Viewed by 241 | Submission Open
Keywords: cancer stem cells; machine learning; deep learning; therapeutic response; molecular markers; cancer
(This special issue belongs to the Section Molecular Oncology)
Recent Advances in Iron Metabolism, Ferritin and Hepcidin Research: 3rd Edition
edited by
submission deadline 30 May 2026 | 5 articles | Viewed by 10459 | Submission Open
Keywords: iron; hepcidin; ferroportin; ferritin; regulation; anemia; therapies; cell signaling; inflammation; disorders
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
The Role of Glycans in Immune Regulation
edited by Senlian Hong
submission deadline 30 May 2026 | 2 articles | Viewed by 9151 | Submission Open
Keywords: glycoimmunology; glycotherapy; vaccines; glycan synthesis; immune tolerance
(This special issue belongs to the Section Molecular Immunology)
Innovative Molecular Target and Therapeutic Approaches in Fatty Liver Disease
edited by
submission deadline 30 May 2026 | 1 articles | Viewed by 8116 | Submission Open
Keywords: liver; fatty liver disease; steatosis; rectors; ARA; THR-Beta; IL-22; glucagon; CRISPR-Case9; randomized clinical trials
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cytokines and Inflammatory Diseases
edited by
submission deadline 30 May 2026 | 2 articles | Viewed by 2590 | Submission Open
Keywords: inflammation; cytokines; interleukin-6; immune diseases; immune signaling; autoimmunity; brain inflammation
(This special issue belongs to the Section Molecular Immunology)
Anticancer, Anti-Inflammatory and Antioxidant Properties of Active Substance and Natural Products
edited by Emira D’Amico
submission deadline 30 May 2026 | 3 articles | Viewed by 1906 | Submission Open
Keywords: anticancer activity; anti-inflammatory activity; oxidative stress; immunomodulation; drug discovery; natural products; active substance; plant extracts; phytochemicals
(This special issue belongs to the Section Molecular Biology)
Oral Cancer: From Molecular Mechanisms to Therapeutics
edited by Diana Russo
submission deadline 30 May 2026 | 2 articles | Viewed by 1796 | Submission Open
Keywords: oral cancer; molecular mechanisms; carcinogenesis; therapeutic strategies; biomarkers; immunotherapy; tumor microenvironment; drug resistance; precision medicine; head and neck oncology
(This special issue belongs to the Section Molecular Oncology)
Antimicrobial Materials: Novel Studies and Related Applications
edited by
submission deadline 30 May 2026 | 1 articles | Viewed by 1600 | Submission Open
Keywords: antimicrobial materials; functional materials; composite materials; contamination; green materials; green technologies; metallic materials; drug resistance; environmental safety; biocompatibility; biodegradability
(This special issue belongs to the Section Materials Science)
Mitochondrial Metabolism in Human Diseases
edited by Neelanjan Vishnu
submission deadline 30 May 2026 | 2 articles | Viewed by 1106 | Submission Open
Keywords: mitochondrial function; pathophysiology; cellular processes; disease development
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Design, Synthesis, and Biological Evaluation of Novel Bioactive Compounds submission deadline 30 May 2026 | 1 articles | Viewed by 1092 | Submission Open
Keywords: drug design; organic compounds; heterocyclic compounds; synthetic methodologies; medicinal chemistry; bioactive molecules; pharmaceutical applications; structure– activity relationships (SARs); organic synthesis; natural product
(This special issue belongs to the Section Molecular Pharmacology)
Recent Advances in Gastrointestinal Tract Oncology: Pathology, Diagnostics and Therapy (Second Edition)
edited by
submission deadline 30 May 2026 | 1 articles | Viewed by 1072 | Submission Open
Keywords: gastrointestinal cancer; esophageal cancer; gastric (stomach) cancer; colorectal cancer; liver cancer; pancreatic cancer; gallbladder and biliary tract cancer; genetic alterations; molecular subtyping; tumor microenvironment; innovative therapies; targeted therapies; tumor biomarkers
(This special issue belongs to the Section Molecular Oncology)
The Application of Biomaterials in Bone Tissue Repair and Regeneration, 2nd Edition
edited by
submission deadline 30 May 2026 | 1 articles | Viewed by 1069 | Submission Open
Keywords: allograft; autograft; autologous bone; bone; graft materials; mineral substitutes; regeneration
(This special issue belongs to the Section Materials Science)
Molecular Mechanisms in Heart Rate Regulation and Cardiac Arrhythmias
edited by Yingjie Liu
submission deadline 30 May 2026 | 1 articles | Viewed by 999 | Submission Open
Keywords: cardiac arrhythmias; heart rate regulation; molecular mechanisms; intrinsic regulation; neurohumoral regulation; arrhythmia development; treatment strategies
(This special issue belongs to the Section Molecular Biology)
Oral Diseases and Oral Soft Tissue Repair
edited by Diana Russo
submission deadline 30 May 2026 | 1 articles | Viewed by 842 | Submission Open
Keywords: oral medicine; tissue regeneration; photobiomodulation; periodontology; implant dentistry
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Evolution of the Vertebrate Immune System
edited by
submission deadline 30 May 2026 | Viewed by 629 | Submission Open
Keywords: immune system; molecular evolution; V (D) J recombination; RAG transposon; comparative genomics
(This special issue belongs to the Section Molecular Biology)
The Role of Medicinal Plants in Health and Diseases
edited by
submission deadline 30 May 2026 | Viewed by 553 | Submission Open
Keywords: medicinal plants; phytochemicals; natural products; pharmacological activity; herbal medicine; drug discovery; traditional medicine; therapeutic potential
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Atomic-Scale Design of Li-Ion Battery Materials
edited by
submission deadline 30 May 2026 | Viewed by 469 | Submission Open
Keywords: lithium-ion batteries; atomic-scale design; electrode– electrolyte interface; electrolyte engineering; defect chemistry; solid-state batteries
(This special issue belongs to the Section Materials Science)
Unraveling Immunometabolism in Sepsis: From Cellular Reprogramming to Therapeutic Targets
edited by
submission deadline 30 May 2026 | Viewed by 398 | Submission Open
Keywords: sepsis; immunometabolism; metabolic reprogramming; cellular bioenergetics; innate and adaptive immunity; mitochondrial dysfunction; inflammatory signaling; metabolic biomarkers; therapeutic modulation; host– pathogen interactions
(This special issue belongs to the Section Molecular Immunology)
Heavy Metal and Fluoride Stress: Toxicity and Tolerance Mechanisms in Plants
edited by
submission deadline 30 May 2026 | Viewed by 384 | Submission Open
Keywords: heavy metal toxicity; fluoride stress; stress tolerance mechanisms; phytoremediation; oxidative stress response
(This special issue belongs to the Section Molecular Plant Sciences)
Hormetic Responses of Plants to Environmental Stress
edited by
submission deadline 30 May 2026 | Viewed by 367 | Submission Open
Keywords: hormesis; environmental stress; dose– response; molecular mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
Retinal Degeneration: From Pathophysiology to Therapeutic Approaches—4th Edition
edited by
submission deadline 30 May 2026 | 1 articles | Viewed by 291 | Submission Open
Keywords: hereditary retinal disease; retinal inflammation; retinal gene augmentation; editing; optogenetics and splice modulation therapy; natural history studies of the retina; human iPSC-derived retinal organoids and retinal pigment epithelium; retinal iPSC-derived cell therapy; retinal pathology; pre- and clinical gene therapy; animal models for retinal dystrophy; retinal imaging; retina-on-a-chip
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Atherosclerosis: From Molecular Biology to Therapeutic Perspective: 7th Edition submission deadline 30 May 2026 | Viewed by 277 | Submission Open
Keywords: atherosclerosis; vascular smooth muscle cells; inflammation; endothelium; cell senescence; apoptosis; lipid metabolism; oxidative stress; nitric oxide; exosomes; vascular calcification; cytokines; growth factors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Extracellular Matrix Signalling in Health and Disease
edited by
submission deadline 30 May 2026 | Viewed by 247 | Submission Open
Keywords: extracellular; matrix; mechano-transduction; biochemical signalling; cell– matrix interactions; outside-in signalling; matrix remodelling
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Progress in Regenerative Therapy Using Blood-Derived Biomaterials: 2nd Edition
edited by , and Tomoharu Mochizuki
submission deadline 30 May 2026 | Viewed by 245 | Submission Open
Keywords: blood-derived biomaterial; platelet-rich plasma; autologous protein solution; mechanism; platelet; coagulation
(This special issue belongs to the Section Materials Science)
Design and Application of Biocatalysts: Emerging Advances in Enzyme Technology submission deadline 30 May 2026 | Viewed by 228 | Submission Open
Keywords: biocatalysis; enzyme engineering; green chemistry; directed evolution; computational design; industrial enzymes; nano-biocatalysts
(This special issue belongs to the Section Biochemistry)
Oxidative Stress and the Kidney: From Physiological Homeostasis to Pathophysiology and Nutraceutical Interventions submission deadline 30 May 2026 | Viewed by 220 | Submission Open
Keywords: oxidative stress; nutraceuticals; CVD risk; CKD; antioxidant
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Engineering Cell-Derived Nanostructures for Therapeutic Delivery
edited by
submission deadline 30 May 2026 | Viewed by 216 | Submission Open
Keywords: extracellular vesicles (EVs); cell membrane-coated nanoparticles; plant-derived nanostructures (PDNSs); bacterial extracellular vesicles (bEVs); drug delivery; nanomedicine; nano-biointerfaces; bioinspired engineering; biomanufacturing; translational nanotechnology
(This special issue belongs to the Section Molecular Nanoscience)
Natural and Synthetic Compounds for Management, Prevention and Treatment of Obesity, 3rd Edition submission deadline 31 May 2026 | 6 articles | Viewed by 31879 | Submission Open
Keywords: obesity; adipokines; obesogens; genetic predisposition; natural/synthetic compounds; cardiovascular disorders; type II diabetes; non-alcoholic fatty liver disease; cancer
(This special issue belongs to the Section Molecular Pharmacology)
State-of-the-Art Molecular Oncology in Brazil, 3rd Edition submission deadline 31 May 2026 | 7 articles | Viewed by 19506 | Submission Open
Keywords: apoptosis; autophagy; calcium; cancer; cell death; chemotherapy; metabolism; mitochondria; drug resistance; oxidative stress
(This special issue belongs to the Section Molecular Oncology)
Herpes Simplex Virus: Immunity, Pathogenicity, Immune Escape Mechanisms, and Antiviral Strategies submission deadline 31 May 2026 | 2 articles | Viewed by 16360 | Submission Open
Keywords: herpes simplex virus (HSV); latency; immune evasion; tegument proteins; epigenetic mechanisms; viral pathogenesis; antiviral strategies; molecular mechanisms; therapeutic interventions
(This special issue belongs to the Section Molecular Immunology)
Molecular and Translational Research on Bone Tumors, 2nd Edition submission deadline 31 May 2026 | 2 articles | Viewed by 14830 | Submission Open
Keywords: primary bone tumours; metastatic bone tumour; therapy; biomarkers; epigenetic factors; immune-oncology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Therapeutic Targets for Neuroinflammation and Neurodegeneration
edited by Muhammad Sohail Khan and
submission deadline 31 May 2026 | 5 articles | Viewed by 14310 | Submission Open
Keywords: neurodegenerative diseases; inflammatory response; nervous system; neuroinflammations
(This special issue belongs to the Section Molecular Neurobiology)
Selected Papers from the 5th International Symposium on Frontiers in Molecular Science (ISFMS)
edited by , , , Atsushi Shiozaki and Akiyuki Taruno
submission deadline 31 May 2026 | 9 articles | Viewed by 11415 | Submission Open
Keywords: protein structure and function; multidomain proteins; drug design and drug resistance; enzymes; molecular biology of galectins; glycobiophysics; NMR spectroscopy; specific sensory systems; brain and systemic function
(This special issue belongs to the Section Biochemistry)
The Role of Epigenetics in Genome Maintenance and Its Relationship to Organismal Aging and Age-Related Diseases
edited by Berta Vázquez and Gerardo Ferrer
submission deadline 31 May 2026 | 4 articles | Viewed by 8206 | Submission Open
Keywords: chromatin; DNA damage; DNA repair; gene transcription; DNA replication; chromosome segregation; genome integrity; chromosome organization
(This special issue belongs to the Section Molecular Genetics and Genomics)
New Insights into Anticancer Strategies
edited by
submission deadline 31 May 2026 | 3 articles | Viewed by 6974 | Submission Open
Keywords: novel targeted therapy; personalized medicine; nanotechnology; AI and machine learning; combination therapy
(This special issue belongs to the Section Molecular Oncology)
Artificial Intelligence: Applications in the Field of Immune-Mediated Inflammatory Diseases and Onco-Hematology submission deadline 31 May 2026 | 1 articles | Viewed by 3773 | Submission Open
Keywords: artificial intelligence; machine learning; immune-mediated diseases; cancers; hematological ma-lignancies
(This special issue belongs to the Section Molecular Immunology)
Advances in Molecular Pathology and Treatment of Breast Cancer
edited by
submission deadline 31 May 2026 | 2 articles | Viewed by 3527 | Submission Open
Keywords: breast cancer; molecular pathology; precision medicine; antibody-drug conjugates (ADCs); circulating tumor DNA (ctDNA); targeted therapy; immunotherapy; treatment resistance; oligometastatic disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring Abiotic Stress in Plants: Mechanisms, Adaptations, and Mitigation Strategies (2nd Edition)
edited by
submission deadline 31 May 2026 | 3 articles | Viewed by 3251 | Submission Open
Keywords: abiotic stress; plant physiology; stress tolerance; crop resilience; molecular mechanisms; biotechnological interventions
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Pulmonary Hypertension and Interstitial Lung Diseases: Mechanisms and Treatments submission deadline 31 May 2026 | 2 articles | Viewed by 3174 | Submission Open
Keywords: pulmonary hypertension; interstitial lung disease; lung fibrosis; pulmonary hemodynamics; pulmonary function testing; pathogenesis; prognosis; survival; treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in the Pharmacology of Depression and Mood Disorders
edited by
submission deadline 31 May 2026 | 1 articles | Viewed by 2350 | Submission Open
Keywords: new antidepressants; rapid antidepressant action; ketamine in depression; glutamatergic antidepressants; psychedelics in depression; 5-HT receptors as targets for antidepressant research; neu-roplasticity and antidepressant action
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Research on Crop Quality
edited by
submission deadline 31 May 2026 | 3 articles | Viewed by 2296 | Submission Open
Keywords: crop quality; molecular breeding; multi-omics; gene editing; precision agriculture; functional genomics; rice; wheat; maize; barley; sorghum; millet; potato; cotton; molecular markers; genome-wide association studies; genome editing; genome selection; molecular selection; transcriptomics; omics; post-translational regulation; starch; protein; lipids; vitamin; processing quality; eating quality
(This special issue belongs to the Section Molecular Plant Sciences)
Human Virome and Emerging Viruses: Characterization, Interactions, and Molecular Insights submission deadline 31 May 2026 | 2 articles | Viewed by 2050 | Submission Open
Keywords: human virome; molecular virology; functional virology; metagenomics; virus– host interactions; immune modulation; pseudovirus assays; antiviral screening; omics integration; molecular immunology
(This special issue belongs to the Section Molecular Microbiology)
Molecular and Computational Innovations in Forensic Genetics: From Degraded DNA to Predictive Models
edited by Eugenio Alladio and
submission deadline 31 May 2026 | 1 articles | Viewed by 1960 | Submission Open
Keywords: degraded DNA; low-template DNA; molecular forensics; NGS; machine learning; deep learning; chemometrics; data integration; predictive models; forensic applications
(This special issue belongs to the Section Molecular Genetics and Genomics)
Emerging Biomarkers in Cardiovascular Risk Assessment and Myocardial Injury
edited by Beatriz Martín-Carro
submission deadline 31 May 2026 | 3 articles | Viewed by 1918 | Submission Open
Keywords: cardiovascular disease; myocardial injury; heart failure; biomarkers; risk stratification
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Natural Products: Redox Balance, Inflammation Control, and Apoptosis Modulation
edited by Rosanna Avola
submission deadline 31 May 2026 | 1 articles | Viewed by 1348 | Submission Open
Keywords: natural antioxidants; inflammation; apoptosis; bioactive natural products; oxidative stress
(This special issue belongs to the Section Bioactives and Nutraceuticals)
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