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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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HIV Infection, Pathogenesis and Treatment
edited by
submission deadline 31 Jan 2026 | Viewed by 33 | Submission Open
Keywords: HIV Infection; HIV; host immune responses; pathogenesis
(This special issue belongs to the Section Molecular Microbiology)
New Advances in Functional Nanomaterials, Nanomedicines and Biosensors Based on Nucleic Acids
edited by and Peng Cao
submission deadline 31 Jan 2026 | Viewed by 33 | Submission Open
Keywords: nucleic acids; functional nanomaterials; nanomedicine; biosensors; DNA nanotechnology; delivery systems; self-assembly; biomedical imaging; clinical applications; diagnostics
(This special issue belongs to the Section Molecular Nanoscience)
Integrative Omics Strategies for Biomarker Discovery and Mechanistic Insights into Disease
edited by
submission deadline 31 Jan 2026 | Viewed by 33 | Submission Open
Keywords: integrative omics; biomarker discovery; cancer signaling networks; drug resistance; phosphoproteomics; multi-omics integration; systems biology; translational research
(This special issue belongs to the Section Molecular Informatics)
Molecular Research on Zoonotic Diseases: Current Advances and Perspectives submission deadline 31 Jan 2026 | Viewed by 27 | Submission Open
Keywords: emerging zoonoses; re-emerging zoonoses; zoonotic pathogens; control strategies and measures; animal and public health; worldwide
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Nanomedicine for Cancer Diagnosis and Therapy
edited by
submission deadline 31 Jan 2026 | Viewed by 24 | Submission Open
Keywords: nanomaterials; multifunctional properties; anticancer nanotechnology; image guided nano platforms; in vivo evaluation; delivery approaches; immune-nanomedicine
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Mechanisms of Voltage-Gating and Modulation in Ion Channels
edited by Joao Carvalho de Souza
submission deadline 31 Jan 2026 | Viewed by 22 | Submission Open
Keywords: voltage-gated ion channels; voltage sensing; voltage sensor coupling; new modulators; ion channel modulation; cell excitability
(This special issue belongs to the Section Molecular Biophysics)
Molecular Insights and Therapeutic Advances in Cerebral and Spinal Tumors submission deadline 31 Jan 2026 | Viewed by 22 | Submission Open
Keywords: central nervous system tumors; molecular oncology; gliomas and spinal cord neoplasms; targeted therapy and precision medicine; neuro-oncology biomarkers; tumor microenvironment; immunotherapy; translational neuroscience
(This special issue belongs to the Section Molecular Neurobiology)
Abiotic Stress in Plants: Physiological and Molecular Responses
edited by Edyta Zdunek-Zastocka
submission deadline 31 Jan 2026 | Viewed by 17 | Submission Open
Keywords: cold; drought; gene expression; heat; heavy metals; oxidative stress; salinity; stress tolerance; stress perception; stress signaling
(This special issue belongs to the Section Molecular Plant Sciences)
Coordination Chemistry: From Fundamental Principles to Multifunctional Applications
edited by
submission deadline 31 Jan 2026 | Viewed by 14 | Submission Open
Keywords: coordination compounds; metal– ligand interactions; ligand design and synthesis; spectroscopic characterization; coordination geometry; molecular architecture; ion-association complexes; supramolecular chemistry; catalysis and activation mechanisms; functional materials; metal– organic frameworks; magnetism in coordination compounds; redox-active complexes; environmental and green chemistry applications; sensors and molecular devices; bioinorganic chemistry; medicinal coordination chemistry; theoretical and computational coordination chemistry
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Nutrition from Cereal Foods: Molecular Perspectives
edited by
submission deadline 31 Jan 2026 | Viewed by 13 | Submission Open
Keywords: cereal nutrition; molecular bioavailability; plant proteins; foodomics; grain processing; bioactive compounds; gut microbiome; nutraceuticals; food matrices; sustainable foods
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Insights into the Tumor Microenvironment of Pleural Mesothelioma and Opportunities for Novel Treatments
edited by
submission deadline 31 Jan 2026 | Viewed by 12 | Submission Open
Keywords: mesothelioma; tumor-associated stromal cells; immunotherapy; tumor microenvironment; cancer-associated fibroblast; mesenchymal stem cells; endothelial cells; cancer-associated adipocytes
(This special issue belongs to the Section Molecular Oncology)
New Insights into the Mechanisms of Neurodegeneration and Regeneration: From Bench to Bedside
edited by Irina Ivanova Stoyanova
submission deadline 31 Jan 2026 | Viewed by 10 | Submission Open
Keywords: neurodegeneration; neuroregeneration; molecular neurobiology; brain development; developmental brain disorders; synaptogenesis; synaptic plasticity; cognitive neuroscience; neurotrauma
(This special issue belongs to the Section Molecular Neurobiology)
Molecular and Cellular Mechanism in Neuroinflammation Research submission deadline 31 Jan 2026 | Viewed by 8 | Submission Open
Keywords: non-coding RNA; nucleic acids; inflammatory cells; inflammatory mediators; neurotransmitters; neuroinflammation; immune cells; neurodegenerative diseases; cerebrovascular diseases; brain tumors
(This special issue belongs to the Section Molecular Neurobiology)
Characterization of Immune and Inflammatory Tumor Microenvironment on Canine, Feline and Human Species
edited by
submission deadline 31 Jan 2026 | Viewed by 8 | Submission Open
Keywords: inflammation; tumor microenvironment; cancer biomarkers; comparative pathology; cancer epidemiology; cancer risk factors; molecular diagnostics; proteomics; treatment response; targeted therapy; immunotherapy; translation cancer research
(This special issue belongs to the Section Molecular Oncology)
Advances in Animal Nutrition and Muscle Biology
edited by Usuk Jung
submission deadline 31 Jan 2026 | Viewed by 7 | Submission Open
Keywords: animal nutrition; metabolic regulation; molecular biology; molecular mechanisms; skeletal muscle; intramusculuar fat; skeletal muscle fibrosis
(This special issue belongs to the Section Molecular Biology)
Oral Fibrosis and Oral Cancers: From Molecular Targets to Therapeutics
edited by Ila Pant
submission deadline 31 Jan 2026 | Viewed by 4 | Submission Open
Keywords: OSF; oral cancer; myofibroblast activation; collagen homeostasis; cancer stem cells; immunotherapy; monoclonal antibodies; DNA or RNA based targeted therapy; small molecule inhibitors; targeted nano-delivery systems; resistance to targeted therapies; molecular targets; natural compounds
(This special issue belongs to the Section Molecular Oncology)
Molecular Advances in Radiation Oncology: Mechanisms, Immunotherapy and Innovation
edited by Jasna But-Hadžić
submission deadline 31 Jan 2026 | Viewed by 1 | Submission Open
Keywords: molecular radiation oncology; DNA damage response; immunoradiotherapy; radiosensitization; tumor– immune interactions; radiogenomics; predictive biomarkers; combination therapies; translational radiobiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Research of Estrogen Receptors in Health and Diseases submission deadline 31 Jan 2026 | Submission Open
Keywords: estrogen receptors; physiology; pathobiology; cancer; benign diseases and disorders
(This special issue belongs to the Section Biochemistry)
Novel Mechanisms for the Prevention and Treatment of Stroke
edited by
submission deadline 10 Feb 2026 | Viewed by 21 | Submission Open
Keywords: stroke; pathophysiology; mechanisms; comorbidities; treatments
(This special issue belongs to the Section Molecular Neurobiology)
Current Research for Ovarian Cancer Biology and Therapeutics (Second Edition) submission deadline 10 Feb 2026 | Viewed by 19 | Submission Open
Keywords: ovarian cancer; chemotherapy resistance; metastasis; novel therapeutic agents; immunotherapy; CAR-T cells; cancer chemotherapy; pre-clinical models
(This special issue belongs to the Section Molecular Oncology)
Cardiovascular Calcification: New Insights into Degenerative Mechanisms and Therapeutic Perspectives
edited by Antonella Bonetti
submission deadline 10 Feb 2026 | Viewed by 13 | Submission Open
Keywords: ectopic calcification; tissue calcinosis; cardiovascular calcification; anti-calcific effect; calcification reduction; anti-calcific model
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Research in Prediction of Protein Structure and Function, 2nd Edition
edited by
submission deadline 20 Feb 2026 | 5 articles | Viewed by 15709 | Submission Open
Keywords: prediction; protein structure; protein function; protein complex; machine learning; deep learning; multiple sequence alignment
(This special issue belongs to the Section Molecular Informatics)
Chimeric Antigen Receptors Against Cancers and Autoimmune Diseases
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 9178 | Submission Open
Keywords: chimeric antigen receptor (CAR); cancer; autoimmune disease; solid tumor; effector cell; CAR format; CAR transfer; tumor microenvironment; targeted antigen
(This special issue belongs to the Section Molecular Immunology)
Immunotherapy Versus Immune Modulation of Leukemia
edited by Helga Maria Schmetzer
submission deadline 20 Feb 2026 | 2 articles | Viewed by 4869 | Submission Open
Keywords: leukemia; immunotherapy; immune modulation; antileukemic; drug resistance
(This special issue belongs to the Section Molecular Oncology)
Drug-Induced Modulation and Immunotherapy of Leukemia
edited by Helga Maria Schmetzer
submission deadline 20 Feb 2026 | 2 articles | Viewed by 4405 | Submission Open
Keywords: leukemia; dendritic cells; immunotherapy; immune modulation
(This special issue belongs to the Section Molecular Immunology)
Inflammatory Bowel Diseases: Molecular Mechanism and Therapeutics
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4157 | Submission Open
Keywords: inflammatory bowel disease; IBD; ulcerative colitis; Crohn’ s disease; animal models
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Bioactive Compounds in Health and Disease
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4033 | Submission Open
Keywords: phenolic compounds; bioactive compounds; health-promoting properties; human diseases; chronic diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Exploring Novel Molecular, Metabolic and Cellular Mechanisms for Developing New Therapeutic Targets Against Childhood Cancers, 2nd Edition submission deadline 20 Feb 2026 | 3 articles | Viewed by 3522 | Submission Open
Keywords: childhood cancers; rhabdomyosarcoma; leukemias; lymphomas; central nervous system tumors; sarcomas of bone and soft tissue; neuroblastoma; retinoblastoma; rhabdoid tumors; rare cancers; genomic alterations; molecular drivers; tissue microenvironment; development of drugs; therapies
(This special issue belongs to the Section Molecular Oncology)
Molecular Studies in Aging, 2nd Edition
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 3342 | Submission Open
Keywords: senescence; active aging; sarcopenia; osteoporosis; oxidative stress; brain aging; cardiovascular aging
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms, Pathophysiology and Therapeutic Strategies of Chronic Obstructive Pulmonary Disease (COPD)
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3102 | Submission Open
Keywords: chronic obstructive pulmonary disease (COPD); pathophysiology; novel therapeutic approaches; biomarkers; pulmonary rehabilitation; inflammation; oxidative stress; genetic factors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
In Silico Methods of Assessing the Therapeutic Potential of Natural Substances submission deadline 20 Feb 2026 | 3 articles | Viewed by 2364 | Submission Open
Keywords: in silico screening; natural products; molecular docking; computational drug discovery; QSAR modeling; molecular dynamics simulations; natural compounds; drug-target interactions; virtual screening; structure-activity relationships; computational chemistry; cheminformatics; ADMET prediction; bioinformatics; phytochemicals; machine learning in drug discovery; computer-aided drug design; pharmacophore modeling; natural therapeutics; computational pharmacology
(This special issue belongs to the Section Molecular Informatics)
Advances in Insulin Resistance Research: 2nd Edition
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2031 | Submission Open
Keywords: insulin resistance; obesity; metabolic diseases; diabetes; metabolism; inflammation
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Probiotics in Health and Disease
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2013 | Submission Open
Keywords: probiotic; microbiota; quality; dysbiosis
(This special issue belongs to the Section Molecular Microbiology)
Sperm Oxidative Stress and Male Infertility
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 1852 | Submission Open
Keywords: oxidative stress; antioxidant system; free radical scavengers; sperm DNA oxidation; sperm DNA fragmentatio; antioxidant therapy; male infertility; male oxidative stress infertility
(This special issue belongs to the Section Molecular Biology)
Molecular Biology of Lung Cancer: From Intrinsic to Acquired Resistance Mechanisms submission deadline 20 Feb 2026 | 1 articles | Viewed by 1775 | Submission Open
Keywords: lung cancer; NSCLC; cancer therapy; resistance; DNA methylation
(This special issue belongs to the Section Molecular Oncology)
New Insights into the Antibacterial Effect of Nano- and Micro-Materials submission deadline 20 Feb 2026 | 1 articles | Viewed by 1705 | Submission Open
Keywords: antibacterial coatings; biomaterials; medical devices; antimicrobial resistance; nanomedicine
(This special issue belongs to the Section Materials Science)
Micro(nano) Plastics and Estrogens as Endocrine Disruptors Meet the Female Reproductive System, Breast and Colon: What Is Going On? submission deadline 20 Feb 2026 | 1 articles | Viewed by 1624 | Submission Open
Keywords: micro(nano) plastics; estrogens; endocrine disruptors; female reproductive system; breast; colon
(This special issue belongs to the Section Molecular Biology)
Molecular Diagnosis in Cardiovascular Diseases
edited by Calogera Pisano, and Giuseppe Raffa
submission deadline 20 Feb 2026 | 2 articles | Viewed by 1623 | Submission Open
Keywords: cardiac diseases; molecular diagnosis; aortopathy; aneurysm; dissection; heart failure
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Functional Genomics of Insects: Unraveling Genetic Mechanisms and Applications
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 1508 | Submission Open
Keywords: genomics; comparative genomics; gene regulation networks; developmental biology; metamorphosis; vector biology; insecticide resistance mechanisms; insect– plant interactions; environmental adaptation
(This special issue belongs to the Section Molecular Genetics and Genomics)
Gut Microbiota and Nutrition in Human Health (2nd Edition)
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1229 | Submission Open
Keywords: microbiome; gut; brain; obesity; diabetes; inflammation; liver; nutrition; probiotic; prebiotic
(This special issue belongs to the Section Molecular Microbiology)
Molecular Research of Gut Microbiota in Human Health and Diseases submission deadline 20 Feb 2026 | Viewed by 804 | Submission Open
Keywords: gut microbiota; gut metabolites; gastroenterology; microbiology; inflammation; human diseases
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms and Therapeutic Targets in Cardiometabolic Disorders
edited by Massimiliano M. Corsi Romanelli and
submission deadline 20 Feb 2026 | 1 articles | Viewed by 790 | Submission Open
Keywords: atherosclerosis; angiotensin; endothelial cell; inflammation; biomarkers; gLP-1; sT-2
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Therapeutic Potential: Exploring Membrane Transporters and Channels as Drug Targets
edited by
submission deadline 20 Feb 2026 | Viewed by 734 | Submission Open
Keywords: membrane transporters; channels; drug targets; therapeutic potential; neurological disorders; metabolic syndromes; methodologies; mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Environmental Heavy Metals with Their Benefits and Risks for Human Health
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 722 | Submission Open
Keywords: heavy metals; metal compound; iron; copper; cadmium; arsenic; oxidative stress; cell death; toxicology; Wilson disease; hemochromatosis
(This special issue belongs to the Section Molecular Toxicology)
Biomechanics and Molecular Research on Glioblastoma: 2nd Edition
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 675 | Submission Open
Keywords: GBM; molecular pathways; biomechanics; oncogene; cancer; microenvironment; drug targeting; diagnostic; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
The Diversity of Life: Light to Heavy Metal Coordination Compounds of Biological Relevance
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 632 | Submission Open
Keywords: coordination compounds; metal-based drugs; antimicrobial; anti-inflammatory; antiviral agents; cancer therapy; drug delivery systems
(This special issue belongs to the Section Biochemistry)
Exploring the Genetics in Rare Diseases: A Genomic Odyssey
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 615 | Submission Open
Keywords: novel discoveries in rare disorders; polygenic risk scores; mosaicism; protein interaction; tools utilized to engineer DNA; somatic variants; patient advocacy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Interactions and Advanced Computational Methods for Biomolecular Systems
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 592 | Submission Open
Keywords: molecular interactions; biological systems; computational biology; protein– protein interactions; protein docking; bioinformatics; structural modeling; multiscale modeling techniques
(This special issue belongs to the Section Molecular Biophysics)
Novel Insights into Buckwheat Reproductive Biology
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 572 | Submission Open
Keywords: antioxidant properties; biotechnological methods; embryology; seed chemical composition; yield
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Pathogenesis and Treatment of Skin Cancer (2nd Edition) submission deadline 20 Feb 2026 | 1 articles | Viewed by 352 | Submission Open
Keywords: melanoma; squamous cell carcinoma; basal cell carcinoma; tumor microenvironment; epithelial– mesenchymal transition (EMT) process; ultraviolet radiation; oxidative stress; bioactive modulators; signal transduction pathways
(This special issue belongs to the Section Molecular Oncology)
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