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Molecular Research on Pathogenesis and Treatment of Pregnancy Complications

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Guest Editor
Department of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA
Interests: preeclampsia; genetics; maternal-fetal medicine; HELLP syndrome; developmental origins of health and disease; pregnancy
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Special Issue Information

Dear Colleagues,

Pregnancy is a complex condition in which maternal, fetal, and paternal factors all play a role in the outcome. A growing body of evidence suggests that the in utero period is extremely important for the future health of the offspring and the mother.

With this Special Issue, we aim to advance the current understanding of pregnancy complications from a molecular perspective. In doing so, we can gain information about the underlying processes that can lead to poor outcomes. Such insights may lead to the development of preventive or therapeutic treatments targeted at addressing the molecular underpinnings of the processes leading to pregnancy complications.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Molecular mechanisms associated with etiology of any pregnancy complication;
  • Placental and fetal contributions to pregnancy complications;
  • Omics and genetic association studies;
  • Molecular interactions at the maternal and fetal interface;
  • Development of novel preventative or therapeutic treatments;
  • Biomarker discovery.

Sincerely,

Dr. Melissa Wilson
Guest Editor

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Keywords

  • hypertensive disorders of pregnancy
  • preeclampsia
  • molecular biology
  • biomarker
  • prevention
  • therapeutics
  • placenta

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Published Papers (1 paper)

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Research

23 pages, 5360 KiB  
Article
The Protective Effects of Burdock Fructooligosaccharide on Preterm Labor Through Its Anti-Inflammatory Action
by Qunfei Ma, Ruoheng Du, Peihua Long, Kaiyi Sun, Youxia Wang, Ye Yang, Xinyu Shen and Lu Gao
Int. J. Mol. Sci. 2025, 26(6), 2659; https://doi.org/10.3390/ijms26062659 - 15 Mar 2025
Viewed by 522
Abstract
Most pharmacotherapeutic chemicals/interventions used to manage preterm labor (PTL) often cause neonatal morbidity and maternal adverse reactions. Fructooligosaccharides, extracted from traditional Chinese medicine, can alleviate inflammation, demonstrate antiviral capabilities, and protect against antioxidant stress, implying a potential effective PTL treatment. In this study, [...] Read more.
Most pharmacotherapeutic chemicals/interventions used to manage preterm labor (PTL) often cause neonatal morbidity and maternal adverse reactions. Fructooligosaccharides, extracted from traditional Chinese medicine, can alleviate inflammation, demonstrate antiviral capabilities, and protect against antioxidant stress, implying a potential effective PTL treatment. In this study, we explored the protective effects of the purified burdock fructooligosaccharide (BFO), a Gfn-type fructose polymer, on inflammation-induced PTL. It was found that two doses of 30 mg/kg mouse BFO administration to pregnant mice at a 6 h interval can effectively ameliorate lipopolysaccharide (LPS)-induced PTL. Drug dynamic distribution analysis revealed that BFO was rather highly enriched in myometrial tissues, could inhibit oxytocin-induced uterine smooth muscle contraction, and could bind toll-like receptor 4 (TLR4) on the membrane of uterine smooth muscle cells, downregulating the expression of downstream genes, attenuating the upregulation of inflammatory cytokines in serum and the myometrium, as well as reversing the increased macrophage and neutrophil infiltration into the myometrium induced by LPS. It can also interfere with the levels of estrogen and progesterone, alleviating the occurrence of premature birth. These findings collectively suggest that BFO might serve as a promising therapeutic agent for inflammation-related preterm labor to safeguard the health of both the mother and fetus. Full article
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