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Novel Trends in the Research of Molecules Involved in Skin Inflammation and Dermatologic Conditions

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 December 2025 | Viewed by 571

Special Issue Editor


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Guest Editor
1. Department of Dermatology and Venereology, Sestre Milosrdnice University Hospital Centre, 10 000 Zagreb, Croatia
2. School of Dental Medicine, University of Zagreb, 10 000 Zagreb, Croatia
Interests: dermatovenerology; allergy; skin inflammation; microbiome; psychoneuroimmunology; multidisciplinary; mucocutaneous diseases
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Special Issue Information

Dear Colleagues,

Based on evidence that skin is the largest organ, various skin lesions and concomitant disturbances (like itch) may manifest/appear on it. Therefore, clinical manifestations of skin conditions are the consequence of the development of various processes that involve various molecules. Thus, many factors participate in their pathogenesis and treatment, such as immune factors, genetic factors, microbial factors, and others. So, for skin inflammatory conditions, searching for molecules involved in pathogenesis is important, especially for chronic dermatoses, which are common and have a significant impact on patients' quality of life. The approach and management to the patients with skin inflammation and other dermatologic conditions and their treatment, especially for chronic inflammatory skin diseases, is often challenging. Therefore, a major challenge in dermatological practice is to cause resolution of skin manifestations or to promote skin healing. Today, based on the study results, there are many new drugs for various dermatoses (previously there was no therapy for years), based on the improved understanding of the pathogenesis of skin inflammation and dermatologic conditions. So, it is important to determine various molecules that participate in their processes to reach effective and often targeted therapies.

The aim of this Special Issue is to present novel trends on research of molecules involved in skin inflammation and dermatologic conditions, including chronic inflammatory skin diseases such as atopic dermatitis, psoriasis, contact dermatitis, acne, chronic urticaria, chronic wounds, rosacea, seborrheic dermatitis, prurigo, lichen, hidradenitis suppurativa, and others, as well as to gather research on current trends, recent advances, and future perspectives in the management of inflammatory skin diseases and other dermatologic conditions. In addition, we would like to present data on new therapies in this medical field, with exciting data that can help practitioners and patients. I look forward to receiving your contributions through your original research or reviews.

Prof. Dr. Liborija Lugovic-Mihic
Guest Editor

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Keywords

  • atopic dermatitis
  • contact dermatitis
  • psoriasis
  • urticaria
  • eczema
  • acne
  • rosacea
  • seborrheic dermatitis
  • drug-induced reaction
  • prurigo nodularis
  • lichen
  • hidradenitis suppurativa
  • alopecia
  • chronic urticaria
  • skin tumor
  • angioedema
  • venous ulcer
  • HPV skin manifestations
  • skin infection
  • vitiligo

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Published Papers (1 paper)

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Research

10 pages, 869 KiB  
Article
Uncovering the Distinct Role of Phleum p 4 in Grass Pollen Allergy: Sensitization Patterns in 1963 Swiss Patients
by Patrick Frey, Phil Cheng, Peter Schmid-Grendelmeier and Carole Guillet
Int. J. Mol. Sci. 2025, 26(12), 5616; https://doi.org/10.3390/ijms26125616 - 11 Jun 2025
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Abstract
Grass pollen allergies significantly contribute to atopic diseases such as asthma and allergic rhinitis, resulting in considerable healthcare burdens. Objective: In this study, molecular sensitization patterns to grass pollen in Swiss patients were addressed. The research utilized a retrospective cohort approach using ImmunoCAP™ [...] Read more.
Grass pollen allergies significantly contribute to atopic diseases such as asthma and allergic rhinitis, resulting in considerable healthcare burdens. Objective: In this study, molecular sensitization patterns to grass pollen in Swiss patients were addressed. The research utilized a retrospective cohort approach using ImmunoCAP™ ISAC testing from October 2015 to July 2020. Clinical histories, demographics, and skin prick test results were collected for analysis. The minimum patient age was 18 years and the average patient age was 41.3 years, with a female predominance (68.5%). In total, 4814 measurements were analyzed. Allergic rhinitis was the most common clinical symptom, followed by asthma and urticaria. A total of 1963 patients (40.8%) revealed sensitization to grass pollen. The most common sensitizations were found to the major allergens Phl p 1 (86%) and Phl p 5 (65%), but also to Phl p 4 (62%). Monosensitization was mostly found to allergens Phl p 1 (266/13.5%) and Phl p 4 (157/7.9%), and less so to Phl p 5 (33/1.7%). Notably, the Phl p 4-monosensitized subgroup showed only an 18% positivity rate in skin prick tests and presented mostly with urticaria. This study gives insights into the spectrum of grass pollen allergies in a Central European setting and underscores the possibly underestimated role of Phl p 4 among grass pollen allergens, especially in a subgroup that suffers mainly from seasonal urticaria. Monovalent sensitization to Phl p 4 can also cause seasonal rhinitis and might therefore be missed if only Phl p 1/p 5 are tested. A better understanding of sensitization patterns will further improve diagnosis and treatment options. Full article
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